公开(公告)号：JPH1068724A

公开(公告)日：1998-03-10

申请号：JP15117397

申请日：1997-06-09

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94

Abstract: PROBLEM TO BE SOLVED: To verify activity related to treatment by bringing LC 132 receptor in contact with a compound supposed to be agonist of the receptor and detecting the bonding of the compound with LC 132 receptor and/or agonist activity. SOLUTION: An LC 132 receptor is brought in contact and react with a compound which bonds with an LC 132 (opioid like) orphan receptor and is supposed to have the LC 132 receptor agonist function thereby adjusting the function of the LC 132 receptor. Then, it is labeled and laid on the compound so that the bonding of the LC 132 receptor is detected. The agonist activity is measured by an inhibition degree of cAMP cumulation caused by false choline stimulus in a host cell which is transfected by a vector expressing the LC 132 receptor. Next, the agonist activity is tested by a screening assay of psychiatric and/or neurological disorder.

公开(公告)号：EP0813065A3

公开(公告)日：1998-07-22

申请号：EP97109078

申请日：1997-06-05

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/94 ,  G01N33/566 ,  A61K38/10

CPC classification number: G01N33/9486 ,  G01N2500/00

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：BR9703546A

公开(公告)日：1998-09-29

申请号：BR9703546

申请日：1997-06-13

Applicant: HOFFMANN LA ROCHE

Inventor： NOTHACKER HANS PETER ,  MOREAU JEAN LUC ,  REINSCHEID RAINER ,  CIVELLI OLIVER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  C07K7/08

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：ZA975077B

公开(公告)日：1997-12-15

申请号：ZA975077

申请日：1997-06-09

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHELD RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  G01N ,  A61K

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：CA2206192A1

公开(公告)日：1997-12-13

申请号：CA2206192

申请日：1997-05-27

Applicant: HOFFMANN LA ROCHE

Inventor： NOTHACKER HANS-PETER ,  CIVELLI OLIVIER ,  MOREAU JEAN-LUC ,  REINSCHEID RAINER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  C12Q1/00

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. Moreparticularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：NO972707D0

公开(公告)日：1997-06-12

申请号：NO972707

申请日：1997-06-12

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：DK1178990T3

公开(公告)日：2003-05-26

申请号：DK00936713

申请日：2000-05-05

Applicant: HOFFMANN LA ROCHE

Inventor： JENCK FRANCOIS ,  HUNKELER WALTER ,  MARTIN JAMES RICHARD ,  SLEIGHT ANDREW ,  HOFFMANN-EMERY FABIENNE

IPC: A61K31/5513 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  C07D487/04

Abstract: The present invention relates to compound 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one (I)and to the use of the compound of formula I for the manufacture of medicaments to be used as anxiolytic and/or anticonvulsant and/or non-sedative sleep-inducing medicaments.

公开(公告)号：HU9701032A2

公开(公告)日：1998-08-28

申请号：HU9701032

申请日：1997-06-11

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：CZ9701795A3

公开(公告)日：1998-03-18

申请号：CZ179597

申请日：1997-06-11

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN LUC ,  NOTHACKER HANS PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94

CPC classification number: G01N33/9486 ,  G01N33/566 ,  G01N2500/00

公开(公告)号：ZA9705077B

公开(公告)日：1997-12-15

申请号：ZA9705077

申请日：1997-06-09

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHELD RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  G01N ,  A61K

CPC classification number: G01N33/9486 ,  G01N33/566 ,  G01N2500/00