公开(公告)号：CA3061574A1

公开(公告)日：2019-01-10

申请号：CA3061574

申请日：2018-06-29

Applicant: HOFFMANN LA ROCHE

Inventor： MUELLER ULRICH ,  WIEDER HERBERT ,  POGGENWISCH ALEXANDER ,  DELVENTHAL ULI ,  KNOERZER ANDREAS

IPC: A61B5/145 ,  A61B5/1486

Abstract: A method for detecting in-vivo properties of a biosensor (110) is disclosed. Herein the biosensor (110) is, in interoperation with an electronics unit (202), adapted for electrochemically determining at least one value of an analyte (136) in a sample of a body fluid (140), wherein the biosensor (110) comprises at least one working electrode (120), wherein the working electrode (120) is covered by a membrane (132) and includes an enzyme (134) for providing a reaction with the analyte (136), wherein the membrane (132) has an electrical resistance and the working electrode (120) has an electrical capacitance. Further, the electronics unit (202) is adapted for measuring a raw current and a current response indicative of an admittance of the biosensor (110). Herein, the method comprises the steps of: a)providing a sensitivity-to-admittance relation of the biosensor (110); b) measuring a raw current in the biosensor (110); c) measuring an in-vivo current response indicative of the in-vivo admittance of the biosensor (110), wherein the in-vivo current response is measured at at least one first operating point (156) and at at least one second operating point (158), wherein the first operating point (156) is selected for providing a first characteristic value being related to the electrical resistance of the membrane (132), and wherein the second operating point (158) is selected for providing a second characteristic value being related to the electrical capacitance of the working electrode (120); d) determining an analyte (136) value in a sample of a body fluid (140) by using the raw current and compensating an in-vivo sensitivity drift in the biosensor(110) by correcting the measured value for the raw current by determining an actual value of the sensitivity by using the first characteristic value, whereby the sensitivity-to- admittance relation as provided during step a) is taken into account;and e)monitoring a fail safe operation of the biosensor (110) based on the first characteristic value and/or the second characteristic value. The method and a system (200) comprising a biosensor (100) and an electronics unit (202) may, primarily, be used for a long-term monitoring of an analyte (136) concentration in a body fluid (140), in particular for long-term monitoring of a glucose level,in the field of home care as well as in the filed of professional care.The present method may, especially, allow reducing a number of calibration procedures and, moreover, be capable of relying on a factory calibration of the biosensor (110).

公开(公告)号：CA3053362A1

公开(公告)日：2018-10-11

申请号：CA3053362

申请日：2018-04-04

Applicant: HOFFMANN LA ROCHE

Inventor： KUBE OLIVER ,  WALTER HELMUT ,  POGGENWISCH ALEXANDER

IPC: A61B5/145 ,  A61B5/00

Abstract: The invention concerns a body-wearable medical device (10), such as an analyte monitoring system or a patch-mounted pump, comprising a self-adhering flexible electronics patch (12) which adheres to the skin (50) of a user and is deformable to follow the contour of the skin (50). In order to provide a flexible non-body configuration, the electronics patch (12) includes a flexible printed circuitry (14) which is applied directly on a foil substrate (16), and a user interface (17) is configured for a user control of the device (10).