公开(公告)号：JP2006170974A

公开(公告)日：2006-06-29

申请号：JP2005315006

申请日：2005-10-28

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： RIEBEL STEFAN ,  THOES BRUNO ROBERT ,  AUGSTEIN MANFRED ,  WIEDER HERBERT ,  BAINCZYK GREGOR

IPC: G01N27/28 ,  G01N27/416 ,  G01N27/42 ,  G01N33/483

CPC classification number: G01N33/4875 ,  Y10T29/49002

Abstract: PROBLEM TO BE SOLVED: To provide an analysis system and an analysis method for analyzing a liquid sample on an assay element. SOLUTION: The analysis system comprises equipment for evaluating an electric signal; a test element holder 23 for holding and positioning the assay element 6 at a measurement position; and at least one electrical contact element 4, used for generating electrical connection to the evaluation equipment for electrical contact to at least one electrical contact surface 16 of the assay element 6. In this case, at least one contact element 4 is arranged, so that it travels relative to a test element holder 23. Further, the analysis system has a means 24 of moving the electrical contact element onto the electrical contact surface 16 of the assay element 6 positioned at a measurement position in the test element holder 23. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供用于分析测定元件上的液体样品的分析系统和分析方法。 解决方案：分析系统包括用于评估电信号的设备; 用于将测定元件6保持并定位在测量位置的测试元件保持器23; 以及至少一个电接触元件4，用于产生与评估设备的电连接，用于与测定元件6的至少一个电接触表面16电接触。在这种情况下，布置至少一个接触元件4，使得 此外，分析系统具有将电接触元件移动到位于测试元件保持器23中的测量位置处的测定元件6的电接触表面16上的装置24.

版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2009056311A

公开(公告)日：2009-03-19

申请号：JP2008220404

申请日：2008-08-28

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： WIEDER HERBERT ,  MARQUANT MICHAEL

IPC: A61B5/1473

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B2560/0271

Abstract: PROBLEM TO BE SOLVED: To provide a method for improving the reliability of in vivo measurement using a portable measuring system.
SOLUTION: This measuring system for in vivo monitoring of an analyte concentration is provided with: an electrode system comprising a work electrode 1, a reference electrode 2 and a counter electrode 3; and a potentiostat 4 for adjusting a difference of potential between the electric potential of the work electrode and the electric potential of the reference electrode to a specified value and for detecting the current flow between the work electrode and the counter electrode; wherein the potentiostat comprises a work electrode terminal for connection to the work electrode, a reference electrode terminal for connection to the reference electrode and a counter electrode terminal for connection to the counter electrode. The potentiostat monitors the electric potential of the counter electrode 3 and generates a malfunction signal when the potential comes to lie outside a specified reference range.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种使用便携式测量系统来提高体内测量的可靠性的方法。 解决方案：用于体内监测分析物浓度的测量系统具有：包括工作电极1，参比电极2和对电极3的电极系统; 以及用于将工作电极的电位与参考电极的电位之间的电位差调整到规定值并用于检测工作电极和对电极之间的电流的恒电位仪4; 其中所述恒电位仪包括用于连接到所述工作电极的工作电极端子，用于连接到所述参考电极的参考电极端子和用于连接到所述对电极的对电极端子。 恒电位仪监视对置电极3的电位，当电位超出规定的参考范围时，产生故障信号。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：WO2006136527B1

公开(公告)日：2007-07-12

申请号：PCT/EP2006063208

申请日：2006-06-14

Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH ,  BAINCZYK GREGOR ,  WIEDER HERBERT ,  EISELE THOMAS

Inventor： BAINCZYK GREGOR ,  WIEDER HERBERT ,  EISELE THOMAS

IPC: G01N33/487 ,  B01L99/00

CPC classification number: G01N33/48757 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/112499 ,  Y10T436/144444

Abstract: The invention relates to a test device (110) for determining at least one analyte concentration in a sample by means of at least one test element (136). The test device (110) can especially be used to measure glucose, especially blood sugar, cholesterol and/or coagulation. The inventive test device comprises a housing (112) which can be closed and opened, and a storage device (134) for receiving at least one test element (136). The at least one test element (136) is embodied in the form of a strip, and the storage device (134) comprises a cartridge (134), preferably a replaceable cartridge (134). Said cartridge (134) comprises a plurality of cavities (135) which are used to receive the strip-type test elements (136) essentially in parallel. The inventive test device also comprises a measuring device having at least one measuring position, and a dispensing device (140, 160). Said dispensing device (140, 160) comprises means (140, 166) for transporting the at least one test element (136) out of at least one storage position of the storage device (134) when the housing (112) is opened.

Abstract translation: 提出了一种用于通过至少一个测试元件（136）确定样本中的至少一种分析物浓度的测试装置（110）。 特别地，测试装置（110）可以用于葡萄糖测量，特别是血糖测量，胆固醇测量和/或凝血测量。 根据本发明的测试装置具有处于关闭和打开状态的外壳（112）以及用于接收至少一个测试元件（136）的轴承装置（134）。 所述至少一个测试元件（136）被设计成条形测试元件（136），其中所述轴承装置（134）具有仓库（134），优选为可更换的仓库（134）。 料仓（134）具有多个空腔（135），其中在空腔（135）中，条形测试元件（136）基本上彼此平行地接收。 此外提供了具有至少一个测量位置和输出装置（140,160）的测量装置。 分配器（140,160）具有用于在打开壳体（112）时从存储装置（134）的至少一个存储位置传送至少一个测试元件（136）的装置（140,166）。

公开(公告)号：WO2007048785A3

公开(公告)日：2007-06-21

申请号：PCT/EP2006067709

申请日：2006-10-24

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  RIEBEL STEFAN ,  WIEDER HERBERT ,  BAINCZYK GREGOR ,  AUGSTEIN MANFRED ,  GROSSER ALBERT ,  KUBE OLIVER ,  MEINECKE DIETER ,  THOES BRUNO

Inventor： RIEBEL STEFAN ,  WIEDER HERBERT ,  BAINCZYK GREGOR ,  AUGSTEIN MANFRED ,  GROSSER ALBERT ,  KUBE OLIVER ,  MEINECKE DIETER ,  THOES BRUNO

IPC: G01N33/487 ,  G01N33/50

CPC classification number: G01N33/48785 ,  A61B5/14532

Abstract: The invention relates to an apparatus for analyzing a sample on a test element. Said apparatus comprises at least one electrically contacting component (123, 124, 125, 126, 127, 128, 129, 130, 131, 132) for transmitting power, which is suitable for establishing electric contact to at least one other component. The electrically contacting component (123, 124, 125, 126, 127, 128, 129, 130, 131, 132) is embodied as an injection-molded circuit support (MID).

Abstract translation: 本发明涉及一种分析器，用于分析测试元件上的样品，含有至少用于功率传输的电接触的构件（123，124，125，126，127，128，129，130，131，132），其用于产生电 合适的接触到至少一种其它组分。 所述电接触件（123，124，125，126，127，128，129，130，131，132）是注射成型的电路载体（MID）。

公开(公告)号：SI3220137T1

公开(公告)日：2019-05-31

申请号：SI201630237

申请日：2016-03-14

Applicant: HOFFMANN LA ROCHE ,  HOFFMANN LA ROCHE

Inventor： RINGEMANN CHRISTIAN ,  WIEDER HERBERT

IPC: G01N27/00 ,  C12Q1/00

公开(公告)号：WO2006136527A3

公开(公告)日：2007-04-26

申请号：PCT/EP2006063208

申请日：2006-06-14

Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH ,  BAINCZYK GREGOR ,  WIEDER HERBERT ,  EISELE THOMAS

Inventor： BAINCZYK GREGOR ,  WIEDER HERBERT ,  EISELE THOMAS

IPC: G01N33/487 ,  B01L99/00

CPC classification number: G01N33/48757 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/112499 ,  Y10T436/144444

Abstract: The invention relates to a test device (110) for determining at least one analyte concentration in a sample by means of at least one test element (136). The test device (110) can especially be used to measure glucose, especially blood sugar, cholesterol and/or coagulation. The inventive test device comprises a housing (112) which can be closed and opened, and a storage device (134) for receiving at least one test element (136). The at least one test element (136) is embodied in the form of a strip, and the storage device (134) comprises a cartridge (134), preferably a replaceable cartridge (134). Said cartridge (134) comprises a plurality of cavities (135) which are used to receive the strip-type test elements (136) essentially in parallel. The inventive test device also comprises a measuring device having at least one measuring position, and a dispensing device (140, 160). Said dispensing device (140, 160) comprises means (140, 166) for transporting the at least one test element (136) out of at least one storage position of the storage device (134) when the housing (112) is opened.

Abstract translation: 它提出了一种用于通过至少一个测试元件（136）的装置测定样品中至少一种分析物浓度的测试装置（110）。 特别地，该测试装置（110），用于葡萄糖测量，特别是血糖测量，胆固醇测量和/或凝固测量都可以使用。 本发明的测试装置包括具有封闭用于接收至少一个测试元件（136）的壳体（112）和在一个开放的状态，和一个存储装置（134）。 所述至少一个测试元件（136）被设计为一个条状测试元件（136），所述轴承装置（134）包括一个盒（134），优选地可移除的盒（134）。 该杂志（134）具有多个空腔（135），其中，所述带状的测试元件（136）被添加到彼此基本上在孔（135）平行的。 此外，具有至少一个测量位置，并提供一个输出装置（140，160）的测量装置。 输出设备（140，160）包括用于将所述轴承装置（134）用于打开所述壳体（112）中的至少一个轴承位置的至少一个检测元件（136）上的滑架装置（140，166）。

公开(公告)号：WO2006058653A3

公开(公告)日：2006-09-08

申请号：PCT/EP2005012568

申请日：2005-11-24

Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH ,  BAINCZYK GREGOR ,  MARQUANT MICHAEL ,  WIEDER HERBERT

Inventor： BAINCZYK GREGOR ,  MARQUANT MICHAEL ,  WIEDER HERBERT

IPC: G01N33/487

CPC classification number: G01N33/48757 ,  G01N33/48771 ,  G01N33/523

Abstract: Portable diagnostic systems (114) which determine substance concentrations in liquid samples are required especially for measuring blood glucose levels. The invention therefore relates to a diagnostic system (114) comprising a diagnostic module (112) with an integrated lancet system (612) and a magazine module (110) which is used for storing test strips (310) and is separated from the diagnostic module (112). The inventive diagnostic system further comprises a device (122, 130) for connecting the magazine module (110) to the diagnostic module (112). Said connecting device (122, 130) is provided with a mechanism (610) for tensioning the lancet system (612) or is connected to such a tensioning mechanism (610) in such a way that the lancet system (612) is tensioned when the magazine module (110) is joined to the diagnostic module (112). Alternatively or additionally, the connecting device (122, 130) can be embodied such that a test strip (130) is discharged when the two modules are joined. Moreover, loading data of the test strips (310) in the magazine module (110) can be exchanged between the magazine module (110) and the diagnostic module (112) when the magazine module (110) is joined to the diagnostic module (112). The disclosed diagnostic system (114) is characterized in that the same is easy and safe to handle.

Abstract translation: 特别地，血液中的葡萄糖浓度的便携式诊断系统（114）是必需的，其确定液体样品中的物质的浓度的测量的领域。 因此，提出了一种诊断系统（114），其包括具有集成Lanzettensystern（612）和诊断模块（112）分别弹匣模块（110）的诊断模块（112），用于存储测试条（310）。 该诊断系统还包括用于将弹匣模块（110）连接到所述诊断模块（112）的连接装置（122，130）。 此连接装置（122，130）包括任一本身的张紧装置（610），用于上或与这样的夹紧装置拉紧刺血针系统（612）（610）连接，使得当所述弹匣模块（110）的所述诊断模块（112）的连接 刺血针系统（612）被拉紧。 可替换地或附加地，该连接装置（122，130）还可以被配置成连接测试条（130）的输出时，使得实现。 此外，在该杂志的模块（110），以诊断模块（112）的化合物发生的弹匣模块（110）和诊断模块（112）之间的弹匣模块（110）在测试条（310）的计费信息的交换。 述（114）的诊断系统的特征在于，通过简单且安全的操作。

公开(公告)号：BR112021008435A2

公开(公告)日：2021-09-14

申请号：BR112021008435

申请日：2019-10-28

Applicant: HOFFMANN LA ROCHE

Inventor： LIMBURG BERND ,  MELCHINGER CHRISTIAN ,  SIEFFERT DANIEL ,  HAILER FREDRIK ,  WIEDER HERBERT ,  BERG MAX ,  WETZEL SIMON ,  GUERMAZI ZIED

IPC: A61B5/15 ,  G16H50/00

Abstract: métodos para avaliar a adequação de um dispositivo móvel, para calibrar um dispositivo móvel, para realizar uma medição analítica, programas de computador de adequação, de calibração, de medição, dispositivo móvel e kit. a presente invenção refere-se um método para avaliar a adequação de um dispositivo móvel (112) para realizar uma medição analítica, um método para calibrar um dispositivo móvel (112) para realizar uma medição analítica e um método para realizar uma medição analítica. um método para avaliar a adequação de um dispositivo móvel (112) para realizar uma medição analítica com base em uma reação de formação de cor, o dispositivo móvel (112) com pelo menos uma câmera (113), o método compreende: a) avaliar a capacidade do dispositivo móvel (112) de ter uma ou mais configurações relevantes do dispositivo móvel (112) controladas por um software de usuário em execução no dispositivo móvel (112), as configurações relevantes pertencentes às etapas de processamento de dados brutos de imagem a serem realizadas pelo dispositivo móvel (112), em que as configurações relevantes incluem pelo menos um de: uma transformação de espaço de cores (132) e uma transformação de mapeamento de tom (136); b) se a avaliação na etapa a) indicar que o dispositivo móvel (112) é capaz de ter uma ou mais configurações relevantes controladas pelo software do usuário, fornecendo pelo menos um item de informação de controle, o pelo menos um item de informação de controle indicando que o dispositivo móvel (112) é adequado para realizar a medição analítica; e c) se a avaliação na etapa a) indica que o dispositivo móvel (112) não é capaz de ter uma ou mais configurações relevantes controladas pelo software do usuário, fornecendo pelo menos um item de informação de controle, o pelo menos um item de informação de controle indicando que o dispositivo móvel (112) é inadequado para realizar a medição analítica.

公开(公告)号：DK3220137T3

公开(公告)日：2019-05-06

申请号：DK16160136

申请日：2016-03-14

Applicant: HOFFMANN LA ROCHE

Inventor： WIEDER HERBERT ,  RINGEMANN CHRISTIAN

IPC: G01N27/327 ,  C12Q1/00

公开(公告)号：CA3061574A1

公开(公告)日：2019-01-10

申请号：CA3061574

申请日：2018-06-29

Applicant: HOFFMANN LA ROCHE

Inventor： MUELLER ULRICH ,  WIEDER HERBERT ,  POGGENWISCH ALEXANDER ,  DELVENTHAL ULI ,  KNOERZER ANDREAS

IPC: A61B5/145 ,  A61B5/1486

Abstract: A method for detecting in-vivo properties of a biosensor (110) is disclosed. Herein the biosensor (110) is, in interoperation with an electronics unit (202), adapted for electrochemically determining at least one value of an analyte (136) in a sample of a body fluid (140), wherein the biosensor (110) comprises at least one working electrode (120), wherein the working electrode (120) is covered by a membrane (132) and includes an enzyme (134) for providing a reaction with the analyte (136), wherein the membrane (132) has an electrical resistance and the working electrode (120) has an electrical capacitance. Further, the electronics unit (202) is adapted for measuring a raw current and a current response indicative of an admittance of the biosensor (110). Herein, the method comprises the steps of: a)providing a sensitivity-to-admittance relation of the biosensor (110); b) measuring a raw current in the biosensor (110); c) measuring an in-vivo current response indicative of the in-vivo admittance of the biosensor (110), wherein the in-vivo current response is measured at at least one first operating point (156) and at at least one second operating point (158), wherein the first operating point (156) is selected for providing a first characteristic value being related to the electrical resistance of the membrane (132), and wherein the second operating point (158) is selected for providing a second characteristic value being related to the electrical capacitance of the working electrode (120); d) determining an analyte (136) value in a sample of a body fluid (140) by using the raw current and compensating an in-vivo sensitivity drift in the biosensor(110) by correcting the measured value for the raw current by determining an actual value of the sensitivity by using the first characteristic value, whereby the sensitivity-to- admittance relation as provided during step a) is taken into account;and e)monitoring a fail safe operation of the biosensor (110) based on the first characteristic value and/or the second characteristic value. The method and a system (200) comprising a biosensor (100) and an electronics unit (202) may, primarily, be used for a long-term monitoring of an analyte (136) concentration in a body fluid (140), in particular for long-term monitoring of a glucose level,in the field of home care as well as in the filed of professional care.The present method may, especially, allow reducing a number of calibration procedures and, moreover, be capable of relying on a factory calibration of the biosensor (110).