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    Dihydrobenzodiazepin-2-One Derivatives III
    11.
    发明专利
    Dihydrobenzodiazepin-2-One Derivatives III 未知

    公开(公告)号：JO2495B1

    公开(公告)日：2009-10-05

    申请号：JOP20030009

    申请日：2003-02-02

    Applicant: HOFFMANN LA ROCHE

    Inventor： GEO ADAM ,  ERWIN GOETSCHI ,  JUERGEN WICHMANN ,  THOMAS JOHANNES WOLTERING

    Abstract: The invention relates to dihydro-‎benzo[b][1,4] diazepin-2-one derivatives of ‎the general formula ‎ wherein R1, R2, X and Y are as defined in ‎the specification and R3 is a six-membered ‎aromatic heterocycle containing 1 to 3 ‎nitrogen atoms or a pyridine-N-oxide as ‎further defined in the specification. The ‎invention further relates to medicaments ‎containing these compounds, a process for ‎their preparation as well as their use for ‎preparation of medicaments for the ‎treatment or prevention of acute and/or ‎chronic neurological disorders.

    CARBAMIC ACID DERIVATIVES
    13.
    发明专利
    CARBAMIC ACID DERIVATIVES 未知

    公开(公告)号：JO2236B1

    公开(公告)日：2004-10-07

    申请号：JOP20000049

    申请日：2000-04-13

    Applicant: HOFFMANN LA ROCHE

    Inventor： MUTEL VINCENT ,  VIEIRA ERIC ,  WICHMANN JURGEN ,  KONARD BLEICHER ,  THOMAS JOHANNES WOLTERING

    Abstract: The present invention relates to compounds of formula Wherein R1 signifies hydrogen or lower alkyl R2.R3 signify, independently from each other, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl X signifies O,S or two hydrogen, atoms not forming a bridge A1/A2 signify, independently from each other, phenyl or a 6-membered heterocycle containing 1 or 2 nitrogen atoms B is a group of formula Wherein R3 signifies lower alkyl, lower alkenyl, lower alkinyl, benzyl, lower alkyl- cycloalkyl, lower alkyl- cyano, lower alkyl- pyridinyl, lower alkyl-lower, lower alkoxy-phenyl, lower alkyl-phenyl, which is optionally substituted by lower alkoxy, or phenyl, which is optionally substituted by lower alkoxy, or lower alkyl-thienyl, cycloalkyl, lower alkyl- trifluoromethyl, or lower alkyl – morpholinyl, Y signifies –O,S or a bond Z signifies O.or S Or B is a -5- membered heterocyclic group of formula Wherein R4 and R5 signifies hydrogen, lower alkyl, lower alkoxy, cyclohexyl, lower alkyl- cyclohexyl or trifluoromethyl, with the proviso that at least one of R4 or R5 has to be hydrogen as well as to their pharmaceutically acceptable salts These compounds may be used in the control or prevention of acute and or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, alheimer’s disease, huntington’s chorea, Als, dementia caused by AIDS , eye injuries, retinopathy, cognitive disorders, memory deficits, schizophrenia, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate deficiency functions, such as e’g, muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addition, anxiety, vomiting , acute and chronic pain, dyskinesia and depression

    Dihydrobenzodiazepin-2-One Derivatives III
    17.
    发明专利
    Dihydrobenzodiazepin-2-One Derivatives III 未知

    公开(公告)号：JO2495B

    公开(公告)日：2009-10-05

    申请号：JO20039

    申请日：2003-02-02

    Applicant: HOFFMANN LA ROCHE

    Inventor： GEO ADAM ,  ERWIN GOETSCHI ,  JUERGEN WICHMANN ,  THOMAS JOHANNES WOLTERING

    Abstract: The invention relates to dihydro-‎benzo[b][1,4] diazepin-2-one derivatives of ‎the general formula ‎ wherein R1, R2, X and Y are as defined in ‎the specification and R3 is a six-membered ‎aromatic heterocycle containing 1 to 3 ‎nitrogen atoms or a pyridine-N-oxide as ‎further defined in the specification. The ‎invention further relates to medicaments ‎containing these compounds, a process for ‎their preparation as well as their use for ‎preparation of medicaments for the ‎treatment or prevention of acute and/or ‎chronic neurological disorders.

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