公开(公告)号：BRPI0609719B1

公开(公告)日：2020-12-01

申请号：BRPI0609719

申请日：2006-03-14

Applicant: HOFFMANN LA ROCHE

Inventor： ERWIN GOETSCHI ,  JUERGEN WICHMANN ,  SILVIA GATTI MCARTHUR ,  THOMAS JOHANNES WOLTERING ,  WYLIE SOLANG PALMER

IPC: C07D471/04 ,  A61K31/4745 ,  A61K31/5025 ,  A61K31/519 ,  A61P25/00 ,  C07D487/04

Abstract: derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2, bem como processo para a preparação, composição farmacêutica e emprego dos mesmos. a presente invenção refere-se aos compostos da fórmula (1): um processo para a fabricação dos mesmos, seu emprego para a preparação de medicamentos para tratar distúrbios do cns e composições farmacêuticas contendo-os, em que r¹ a r³, a, m, l, e, g, e j são como definidos na descrição e reivindicações.

公开(公告)号：MY176608A

公开(公告)日：2020-08-18

申请号：MYPI20030378

申请日：2003-02-05

Applicant: HOFFMANN LA ROCHE

Inventor： GEO ADAM ,  THOMAS JOHANNES WOLTERING ,  ERWIN GOETSCHI ,  JUERGEN WICHMANN

IPC: A61K31/5513 ,  A61P25/00 ,  A61P25/18 ,  A61P25/28 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10

Abstract: This invention relates to dihydro-benzo[b][l,4]diazepin-2-one derivatives of the general formula wherein R1, R2, X and Y are as defined in the specification and R3 is a six-membered aromatic heterocyde containing l to 3 nitrogen atoms or a pyridine-N-oxide as further defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.

公开(公告)号：AU2006226669B2

公开(公告)日：2011-12-08

申请号：AU2006226669

申请日：2006-03-14

Applicant: HOFFMANN LA ROCHE

Inventor： JURGEN WICHMANN ,  JOHANNES WOLTERING THOMAS ,  ERWIN GOETSCHI ,  SOLANG PALMER WYLIE ,  SILVIA GATTI MCARTHUR

IPC: C07D487/04 ,  A61K31/4745 ,  A61K31/5025 ,  A61K31/519 ,  A61P25/00 ,  C07D471/04

Abstract: The present invention relates to compounds of formula (I): a process for the manufacture thereof, their use for the preparation of medicaments for treating CNS disorders and pharmaceutical compositions containing them, wherein R to R, A, M, L, E, G, and J are as defined in the description and claims.

公开(公告)号：CL2009000380A1

公开(公告)日：2010-09-21

申请号：CL2009000380

申请日：2009-02-19

Applicant: HOFFMANN LA ROCHE

Inventor： ERWIN GOETSCHI ,  SYNESE JOLIDON ,  HELMUT JACOBSEN ,  ALEXANDER FLOHR ,  KARLHEINZ BAUMANN ,  THOMAS LUEBBERS

IPC: A61K31/506 ,  A61P25/00 ,  A61P25/28 ,  C07D207/04 ,  C07D233/64 ,  C07D239/42 ,  C07D403/14 ,  C07D413/14

Abstract: Compuestos derivados de heterociclos, moduladores de beta-amiloide; proceso de preparación; composición farmacéutica; y uso en el tratamiento de la Enfermedad de Alzheimer, angioplastia cerebral amiloide, demencia multiinfarto, Síndrome de Down, entre otras.

公开(公告)号：ZA200706353B

公开(公告)日：2009-09-30

申请号：ZA200706353

申请日：2007-07-31

Applicant: HOFFMANN LA ROCHE

Inventor： SILVIA GATTI MCARTHUR ,  JUERGEN WICHMANN ,  ERWIN GOETSCHI ,  JOHANNES WOLTERING THOMAS

IPC: A61K20090101 ,  C07D20090101

Abstract: The present invention relates to pyrrazolo-pyrimidine derivatives of formula (I): wherein R 1 to R 4 and A are as defined in the specification, a process for the manufacture thereof, their use for treating or preventing metabotropic glutamate receptors mediated disorders, their use for the preparation of medicaments for treating such disorders and pharmaceutical compositions containing said derivatives.

公开(公告)号：ZA200708028B

公开(公告)日：2008-08-27

申请号：ZA200708028

申请日：2007-09-18

Applicant: HOFFMANN LA ROCHE

Inventor： SILVIA GATTI MCARTHUR ,  SOLANG PALMER WYLIE ,  JOHANNES WOLTERING THOMAS ,  ERWIN GOETSCHI ,  JUERGEN WICHMANN

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.

公开(公告)号：ZA8802382B

公开(公告)日：1989-12-27

申请号：ZA8802382

申请日：1988-04-05

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  ANDRE FURLENMEIER ,  GOETSCHI ERWIN ,  ERWIN GOETSCHI ,  HEBEISEN PAUL ,  PAUL HEBEISEN ,  HOFHEINZ WERNER ,  WERNER HOFHEINZ ,  LINK HELMUT ,  HELMUT LINK

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K

CPC classification number: Y02A50/473

公开(公告)号：BRPI0709633B8

公开(公告)日：2021-05-25

申请号：BRPI0709633

申请日：2007-03-19

Applicant: HOFFMANN LA ROCHE

Inventor： ERWIN GOETSCHI ,  JUERGEN WICHMANN ,  SILVIA GATTI MCARTHUR ,  THOMAS JOHANNES WOLTERING

IPC: C07D213/34 ,  A61K31/444 ,  A61K31/506 ,  A61P25/00 ,  C07D233/96 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14

Abstract: derivados de piridina e pirimidina como antagonistas de mgiur2 composição farmacêutica e uso dos mesmos. a presente invenção refere-se a compostos de fórmula (i), um processo para a fabricação destes, seu uso para a preparação de medicamentos para tratar distúrbios do cns e composições farmacêuticas contendo-os: em que a, b, x, y, r^ 1^, r^ 2^, r^ 3^ e r^ 4^ são como definido na descrição e reivindicações.

公开(公告)号：PT2536710T

公开(公告)日：2016-09-27

申请号：PT11702848

申请日：2011-02-14

Applicant: HOFFMANN LA ROCHE

Inventor： LUKE GREEN ,  SYNESE JOLIDON ,  KARLHEINZ BAUMANN ,  ALEXANDER FLOHR ,  ERWIN GOETSCHI ,  HENNER KNUST ,  ANJA LIMBERG ,  THOMAS LUEBBERS ,  ANDREW THOMAS

IPC: C07D401/14 ,  A61K31/4523 ,  A61P25/28 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

公开(公告)号：JO2285B1

公开(公告)日：2005-09-12

申请号：JOP20020032

申请日：2002-04-10

Applicant: HOFFMANN LA ROCHE

Inventor： MUTEL VINCENT ,  WICHMANN JUERGEN ,  GEO ADAM ,  ERWIN GOETSCHI ,  THOMAS JOHANNES WOLTERING

IPC: C07D243/12 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/00 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14

Abstract: This invention is concerned with dihydro-benzo [b] [1,4] diazepin-2-one derivatives of the general formula: Wherein RI, R2, R3, X and Y are as defined in the specification. The invention further relates to med medicaments containing there compounds, a process for their preparations as well as their use for preparation of medicaments for the treatment for the treatment or prevention of acute and/or chronic neurological disorders