公开(公告)号：WO2010104651A1

公开(公告)日：2010-09-16

申请号：PCT/US2010/024344

申请日：2010-02-17

Applicant: IMRA AMERICA, INC. ,  LIU, Bing ,  HU, Zhendong ,  MURAKAMI, Makoto ,  XU, Jingzhou ,  CHE, Yong

Inventor： LIU, Bing ,  HU, Zhendong ,  MURAKAMI, Makoto ,  XU, Jingzhou ,  CHE, Yong

IPC: B23K26/00

CPC classification number: C23C20/04 ,  B41M5/262 ,  B41M5/267 ,  B44F1/10 ,  C23C14/28 ,  C23C14/3435 ,  G02B26/101 ,  Y10T428/24802 ,  Y10T428/24917

Abstract: A method of forming patterns on transparent substrates using a pulsed laser is disclosed. Various embodiments include an ultrashort pulsed laser, a substrate that is transparent to the laser wavelength, and a target plate. The laser beam is guided through the transparent substrate and focused on the target surface. The target material is ablated by the laser and is deposited on the opposite substrate surface. A pattern, for example a gray scale image, is formed by scanning the laser beam relative to the target. Variations of the laser beam scan speed and scan line density control the material deposition and change the optical properties of the deposited patterns, creating a visual effect of gray scale. In some embodiments patterns may be formed on a portion of a microelectronic device during a fabrication process. In some embodiments high repetition rate picoseconds and nanosecond sources are configured to produce the patterns.

Abstract translation: 公开了使用脉冲激光在透明基板上形成图案的方法。 各种实施例包括超短脉冲激光器，对激光波长透明的衬底和靶板。 激光束被引导通过透明基板并聚焦在目标表面上。 目标材料被激光烧蚀并沉积在相对的基板表面上。 通过相对于目标扫描激光束来形成例如灰度图像的图案。 激光束扫描速度和扫描线密度的变化控制材料沉积并改变沉积图案的光学性质，产生灰度的视觉效果。 在一些实施例中，可以在制造过程期间在微电子器件的一部分上形成图案。 在一些实施例中，高重复率皮秒和纳秒源被配置为产生图案。

公开(公告)号：WO2008118533A2

公开(公告)日：2008-10-02

申请号：PCT/US2008/052544

申请日：2008-01-31

Applicant: IMRA AMERICA, INC. ,  HU, Zhendong ,  CHE, Yong ,  LIU, Bing

Inventor： HU, Zhendong ,  CHE, Yong ,  LIU, Bing

IPC: C23C14/26

CPC classification number: C30B23/08 ,  C23C14/083 ,  C23C14/28 ,  C30B29/16

Abstract: A one-step and room-temperature process for depositing nanoparticles or nanocomposite (nanoparticle-assembled) films of metal oxides such as crystalline titanium dioxide (TiO 2 ) onto a substrate surface using ultrafast pulsed laser ablation of Titania or metal titanium target. The system includes a pulsed laser with a pulse duration ranging from a few femtoseconds to a few tens of picoseconds, an optical setup for processing the laser beam such that the beam is focused onto the target surface with an appropriate average energy density and an appropriate energy density distribution, and a vacuum chamber in which the target and the substrate are installed and background gases and their pressures are appropriately adjusted.

Abstract translation: 用于将金属氧化物如结晶二氧化钛（TiO 2）的纳米粒子或纳米复合材料（纳米粒子组装）膜沉积到基底上的一步和室温方法 表面使用超快脉冲激光烧蚀二氧化钛或金属钛靶。 该系统包括具有从几飞秒到几十皮秒的脉冲持续时间的脉冲激光器，用于处理激光束的光学装置，使得光束以适当的平均能量密度和适当的能量聚焦到目标表面上 密度分布，还有一个真空室，其中安装了靶材和基材，并适当调节背景气体及其压力。

公开(公告)号：WO2014160844A3

公开(公告)日：2014-10-02

申请号：PCT/US2014/031985

申请日：2014-03-27

Applicant: IMRA AMERICA, INC.

Inventor： MURAKAMI, Makoto ,  LIU, Bing

IPC: C40B30/04 ,  G01R33/02 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y25/00

Abstract: Disclosed is process for preparing magnetic nanoparticles (MNPs) that results in very sensitive MNPs that can be used in a variety of diagnostic and analytical methods. The MNPs exhibit superparamagnetism and find special use in giant magnetoresistance sensors (GMRS). The MNPs are created by a process that permits one to tune the size of nanoparticles to a range of from 10 to 20 nanometers with a very small particle size distribution of +/- 2 nanometers or less. The MNPs can be tagged with a variety of markers and thus find use in many analytical assays, cell sorting techniques, imaging methods, drug delivery methods and cancer treatments. The inventive MNPs can be detected in magnetic file strengths of 2000 Oe or less.

公开(公告)号：WO2010087869A1

公开(公告)日：2010-08-05

申请号：PCT/US2009/037643

申请日：2009-03-19

Applicant: IMRA AMERICA, INC. ,  LIU, Bing ,  HU, Zhendong ,  MURAKAMI, Makoto ,  CHE, Yong

Inventor： LIU, Bing ,  HU, Zhendong ,  MURAKAMI, Makoto ,  CHE, Yong

IPC: B02C19/00

CPC classification number: B02C19/18 ,  B01J13/0043 ,  B01J19/121 ,  B22F1/0022 ,  B22F9/04 ,  B22F2999/00 ,  B82Y30/00 ,  B22F2202/11

Abstract: Various embodiments include a method of producing chemically pure and stably dispersed metal and metal-alloy nanoparticle colloids with ultrafast pulsed laser ablation. A method comprises irradiating a metal or metal alloy target submerged in a liquid with ultrashort laser pulses at a high repetition rate, cooling a portion of the liquid that includes an irradiated region, and collecting nanoparticles produced with the laser irradiation and liquid cooling. The method may be implemented with a high repetition rate ultrafast pulsed laser source, an optical system for focusing and moving the pulsed laser beams, a metal or metal alloy target submerged in a liquid, and a liquid circulating system to cool the laser focal volume and collect the nanoparticle products. By controlling various laser parameters, and with optional liquid flow movement, the method provides stable colloids of dispersed metal and metal-alloy nanoparticles. In various embodiments additional stabilizing chemical agents are not required.

Abstract translation: 各种实施方案包括用超快速脉冲激光烧蚀制备化学纯的和稳定分散的金属和金属合金纳米颗粒胶体的方法。 一种方法包括以高重复率以超短激光脉冲辐射淹没在液体中的金属或金属合金靶，冷却包括辐射区域的液体的一部分，以及收集通过激光照射和液体冷却产生的纳米颗粒。 该方法可以用高重复率超快脉冲激光源，用于聚焦和移动脉冲激光束的光学系统，浸没在液体中的金属或金属合金靶和液体循环系统来实现，以冷却激光聚焦体积， 收集纳米颗粒产品。 通过控制各种激光参数，并具有可选的液流运动，该方法提供分散金属和金属合金纳米粒子的稳定胶体。 在各种实施方案中，不需要另外的稳定化学试剂。

公开(公告)号：EP3149484A1

公开(公告)日：2017-04-05

申请号：EP15727198.2

申请日：2015-05-20

Applicant: IMRA America, Inc.

Inventor： QIAN, Wei ,  LIU, Bing ,  FETTERS, Kori Michael

IPC: G01N33/58 ,  C12Q1/37

CPC classification number: C12Q1/37 ,  G01N33/587 ,  G01N2333/81 ,  G01N2333/948

Abstract: In the present invention, a method and assay for the detection of proteases and protease inhibitors using colloidal gold nanoparticles and peptide substrates, which are selectively recognized and cleaved by proteases being assayed, is disclosed. In this assay, the mechanism of signal generation relies on peptide sequence induced aggregation of gold nanoparticles, which are used as signal reporters. The peptide sequences that induce aggregation are either the intact peptide substrates or proteolytic fragments of the intact peptide substrate wherein the proteolytic fragments are produced by the protease being assayed. The present invention provides a novel, simple, sensitive, and inexpensive colloidal gold nanoparticle-based colorimetric assay that allows both visual and quantitative detection of proteases and protease inhibitors.

Abstract translation: 在本发明中，公开了使用被测定的蛋白酶选择性识别和切割的胶体金纳米颗粒和肽底物检测蛋白酶和蛋白酶抑制剂的方法和测定法。 在该测定中，信号发生的机制依赖于肽序列诱导的金纳米颗粒的聚集，其被用作信号记录器。 诱导聚集的肽序列是完整肽底物的完整肽底物或蛋白水解片段，其中蛋白水解片段由待测蛋白酶产生。 本发明提供了一种新颖，简单，灵敏和廉价的基于胶体金纳米粒子的比色测定法，其允许视觉和定量检测蛋白酶和蛋白酶抑制剂。

公开(公告)号：EP2391455A1

公开(公告)日：2011-12-07

申请号：EP09839437.2

申请日：2009-03-19

Applicant: Imra America, Inc.

Inventor： LIU, Bing ,  HU, Zhendong ,  MURAKAMI, Makoto ,  CHE, Yong

IPC: B02C19/00

CPC classification number: B02C19/18 ,  B01J13/0043 ,  B01J19/121 ,  B22F1/0022 ,  B22F9/04 ,  B22F2999/00 ,  B82Y30/00 ,  B22F2202/11

Abstract: Various embodiments include a method of producing chemically pure and stably dispersed metal and metal-alloy nanoparticle colloids with ultrafast pulsed laser ablation. A method comprises irradiating a metal or metal alloy target submerged in a liquid with ultrashort laser pulses at a high repetition rate, cooling a portion of the liquid that includes an irradiated region, and collecting nanoparticles produced with the laser irradiation and liquid cooling. The method may be implemented with a high repetition rate ultrafast pulsed laser source, an optical system for focusing and moving the pulsed laser beams, a metal or metal alloy target submerged in a liquid, and a liquid circulating system to cool the laser focal volume and collect the nanoparticle products. By controlling various laser parameters, and with optional liquid flow movement, the method provides stable colloids of dispersed metal and metal-alloy nanoparticles. In various embodiments additional stabilizing chemical agents are not required.

公开(公告)号：EP2109694A2

公开(公告)日：2009-10-21

申请号：EP08799669.0

申请日：2008-01-31

Applicant: Imra America, Inc.

Inventor： HU, Zhendong ,  CHE, Yong ,  LIU, Bing

IPC: C23C20/04

CPC classification number: C30B23/08 ,  C23C14/083 ,  C23C14/28 ,  C30B29/16

Abstract: A one-step and room-temperature process for depositing nanoparticles or nanocomposite (nanoparticle-assembled) films of metal oxides such as crystalline titanium dioxide (TiO2) onto a substrate surface using ultrafast pulsed laser ablation of Titania or metal titanium target. The system includes a pulsed laser with a pulse duration ranging from a few femtoseconds to a few tens of picoseconds, an optical setup for processing the laser beam such that the beam is focused onto the target surface with an appropriate average energy density and an appropriate energy density distribution, and a vacuum chamber in which the target and the substrate are installed and background gases and their pressures are appropriately adjusted.

公开(公告)号：EP2391455B1

公开(公告)日：2018-05-09

申请号：EP09839437.2

申请日：2009-03-19

Applicant: Imra America, Inc.

Inventor： LIU, Bing ,  HU, Zhendong ,  MURAKAMI, Makoto ,  CHE, Yong

IPC: B02C19/00

CPC classification number: B02C19/18 ,  B01J13/0043 ,  B01J19/121 ,  B22F1/0022 ,  B22F9/04 ,  B22F2999/00 ,  B82Y30/00 ,  B22F2202/11

Abstract: Various embodiments include a method of producing chemically pure and stably dispersed metal and metal-alloy nanoparticle colloids with ultrafast pulsed laser ablation. A method comprises irradiating a metal or metal alloy target submerged in a liquid with ultrashort laser pulses at a high repetition rate, cooling a portion of the liquid that includes an irradiated region, and collecting nanoparticles produced with the laser irradiation and liquid cooling. The method may be implemented with a high repetition rate ultrafast pulsed laser source, an optical system for focusing and moving the pulsed laser beams, a metal or metal alloy target submerged in a liquid, and a liquid circulating system to cool the laser focal volume and collect the nanoparticle products. By controlling various laser parameters, and with optional liquid flow movement, the method provides stable colloids of dispersed metal and metal-alloy nanoparticles. In various embodiments additional stabilizing chemical agents are not required.

公开(公告)号：EP2274771B1

公开(公告)日：2015-07-15

申请号：EP09758837.0

申请日：2009-03-11

Applicant: Imra America, Inc.

Inventor： MURAKAMI, Makoto ,  HU, Zhendong ,  LIU, Bing ,  CHE, Yong ,  LIU, Zhenlin ,  UEHARA, Yuzuru

IPC: H01L21/44 ,  C23C14/28 ,  C23C14/08 ,  H01S3/00 ,  H01S3/23 ,  C23C14/56

CPC classification number: C23C14/28 ,  C23C14/08 ,  C23C14/564 ,  H01S3/0057 ,  H01S3/0085 ,  H01S3/2308

公开(公告)号：EP2109694B1

公开(公告)日：2013-06-26

申请号：EP08799669.0

申请日：2008-01-31

Applicant: Imra America, Inc.

Inventor： HU, Zhendong ,  CHE, Yong ,  LIU, Bing

IPC: C23C20/04 ,  C23C20/02

CPC classification number: C30B23/08 ,  C23C14/083 ,  C23C14/28 ,  C30B29/16