公开(公告)号：EP0350116A2

公开(公告)日：1990-01-10

申请号：EP89201743.5

申请日：1989-06-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N27/28

CPC classification number: G01N27/403

Abstract: An electrochemical cell for measuring the activity of one or more ionic species such as pNa, pK, pCa, pNH₄, pCl etc. consisting of two sensors selective to the actual ionic species, one of which is used as the reference electrode and the other as the measurement electrode.
The two sensors are chosen preferably identical.
The electrode used as the reference electrode is brought into contact with a solution of known ionic activity and an ionic strength which is greater, equal to or substantially greater than that of the unknown solution to be measured.
The measurment electrode is brought into contact with the unknown solution to be measured, while a third electrode is used purely for instrumental reasons and does not participate in the measurement.

Abstract translation: 用于测量一个或多个离子物质的活性的电化学电池：例如PNA，PK，PCA，pNH4，PCL等两个传感器选择性的实际离子物质，它被用作参比电极，另一个为的所有一个由......组成 测量电极。 两个传感器被选择优选相同。 用作参比电极的电极被带入与已知的离子活性的溶液接触，并在离子强度的所有这是更大的，等于或基本上大于所述未知溶液中，以进行测量。 所述measurment电极被带入与所述未知溶液接触要被测量，而第三电极纯粹是用于仪器的原因，不参与在测量中。

公开(公告)号：EP0345882A1

公开(公告)日：1989-12-13

申请号：EP89201409.3

申请日：1989-06-02

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Bonfiglio, Paolo

IPC: G05D23/27 ,  B04B15/02 ,  G01N21/07

CPC classification number: G05D23/27 ,  G01N21/0332 ,  G01N21/07

Abstract: A heating and temperature-control device for biological sample containers comprises an assembly of lamps emitting infrared radiation within a wavelength of 1-5.5 micrometers and heating said containers by irradiation, and a sensor for infrared radiation of wavelength 7-14 micrometers which picks up the emission from the containers which derives from their heating. The signal obtained from said sensor is used to control the lamp emission in such a manner as to obtain the required container temperature and then keep it constant.

Abstract translation: 用于生物样品容器的加热和温度控制装置包括发射波长为1-5.5微米的红外辐射的灯的组件，并通过照射加热所述容器，以及用于红外辐射的传感器，其用于拾取 来自其加热的容器的排放。 从所述传感器获得的信号用于以获得所需容器温度并且然后保持恒定的方式控制灯发射。

公开(公告)号：EP0153783A3

公开(公告)日：1987-12-16

申请号：EP85200206

申请日：1985-02-19

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Premoli, Pietro ,  Manzoni, Angelo ,  Calzi, Claudio

IPC: G01N33/487 ,  G01N27/28

CPC classification number: G01N33/84 ,  H02K19/34 ,  H02K21/48 ,  Y10T436/10 ,  Y10T436/106664

Abstract: Description of a method for the potentiometric determination of the total calcium (II) content in biological fluids (serum, plasma and urine) based on dilution of the sample. The results obtained, when compared to the usual methods in current use, show the validity of the proposed method; furthermore, the pH of the buffer solution used for diluting the sample guarantees optimum operating conditions as well as long working life of the potentiometric sensing elements and maximum reliability when compared to other methods employing acidification of the sample.

公开(公告)号：EP0562694A1

公开(公告)日：1993-09-29

申请号：EP93200854.3

申请日：1993-03-24

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Bonfiglio, Paolo ,  Frackleton, John James

IPC: F16K11/02

CPC classification number: F16K7/17

Abstract: A fluid circulating and intercepting device (10) comprises a first (12) and a second block (11) facing each other with the interposition of an impermeable elastic and flexible diaphragm (13). The first block (12) is provided with at least one concavity (16) with its mouth close to the diaphragm (13) and into which opens out in a substantially axial direction a control fluid feed duct (17). The second block (11) is provided with ducts (14, 15) for circulation of the intercepted fluid which open out on the face in contact with the diaphragm (13), in correspondence with the concavity (16) in the first block (12).

Abstract translation: 流体循环和拦截装置（10）包括彼此面对的第一（12）和第二块（11），其中插入不渗透的弹性和柔性隔膜（13）。 第一块（12）设置有至少一个凹口（16），其口靠近隔膜（13），并且在基本上轴向方向上开放控制流体供给管道（17）。 第二块（11）设有管道（14,15），用于与在第一块（12）中的凹部（16）相对应地在与隔膜（13）接触的面上开放的被截流的流体循环 ）。

公开(公告)号：EP0153783B1

公开(公告)日：1991-10-30

申请号：EP85200206.2

申请日：1985-02-19

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Premoli, Pietro ,  Manzoni, Angelo ,  Calzi, Claudio

IPC: G01N33/487 ,  G01N27/28

CPC classification number: G01N33/84 ,  H02K19/34 ,  H02K21/48 ,  Y10T436/10 ,  Y10T436/106664

公开(公告)号：EP0354604A3

公开(公告)日：1990-08-01

申请号：EP89201744.3

申请日：1989-06-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Premoli, Pietro

IPC: G01N27/416

CPC classification number: G01N27/4162

Abstract: A system is disclosed for measuring the partial pressure of a gas, and in particular of carbon dioxide (p CO ). The system uses an electrolytic solution of weak ionic strenght which is circulated between an ion-selective electrode and a membrane permeable to gases but not to the ions and substantially distant from the electrode. The partial pressure of the gas is measured after a fraction of the electrolytic solution has been permeated by the gas present in the sample and subsequently has been transferred on the sensible portion of the electrode.

公开(公告)号：EP0321032A1

公开(公告)日：1989-06-21

申请号：EP88202827.7

申请日：1988-12-09

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Zaccai, Gianfranco

IPC: A61B5/14

CPC classification number: A61B5/154 ,  A61B5/15003 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150732

Abstract: In a single-use device for collecting and holding blood samples, provision is made for an evacuated tube (10) with a closure (stopper) (11) that can be pierced by the tip of a needle (13), the other tip (14) of which is intended to be inserted into a vein of a patient. Disposed below the said pierceable stopper (11), and in the tube (10), is a diaphragm (16) intended to be passed through by the needle-tip (13) that pierces the stopper (11), so as to form a supplementar barrier between the interior of the tube (10) and the environment when the pierceable stopper (11) is removed.

Abstract translation: 在用于收集和保持血液样品的单次使用装置设置为，在真空管（10）具有一个封闭件（止动器）（11）也可通过针（13），另一个端头的尖端（刺穿制成 14的所有其目的）被插入到病人的静脉中。 设置在所述针刺止栓（11）的下方，并且在所述管（10）旨在是通过由针尖通过膜片（16）（13）做了刺穿塞子（11），以便形成一个 supplementar所述管（10）和所述环境当针刺止栓（11）被移除的内部之间的屏障。

公开(公告)号：EP0123178A2

公开(公告)日：1984-10-31

申请号：EP84103733.6

申请日：1984-04-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N21/07 ,  B04B5/04

CPC classification number: G01N21/07

Abstract: Analytical photometer for the practically simultaneous determination of the presence of different substances in a certain number of discrete samples. The photometer (10) is equipped with a centrifugal type rotor (16), already known in the art, containing a large number of chambers with inlet holes (20, 22) for the sample/samples and reagents and with axially aligned transparent windows, thereby forming a system of rotating cuvettes (18). The rotor compartments (16) serve as receptacles for the solutions and are designed and dimensioned as already known in the art, such as to retain the liquid when said rotor (16) is at rest and to transfer said liquid into the cuvettes (18) when the rotor (16) rotates. A single or multiple light source (L) is provided, which is transmitted in a novel manner through a system of suitable means, in particular, optical fibres (30-35) to various photodetector units (60 to 65), suitably aligned with the transparent windows of the cuvettes (18) by means of the same number of interference filters (50to 55) and appropriate holes (40 to 45) situated in the base (15) of the rotor (16). Thus it is possible to determine for the first time, concentrations of chemical solutions through the absorbance in the sample/samples plus reagent/reagents contained in the cuvettes (18) at various wave lengths, with wave energy being delivered from source (L).
Hence it is possible to examine more than one cuvette (18) almost simultaneously and singly, each one for a different analytical parameter, and consequently to examine the transmittance and/or absorbance of the samples contained in the cuvettes at optimum wave length.

Abstract translation: 分析光度计不同物质在离散样本的特定数目的存在的几乎同时测定。 光度计（10）配备有离心式转子（16），在本领域中已经公知的，含有用于样品/试样和试剂，并与轴向对准的透明窗口的大量具有入口孔腔（20，22）， 从而形成旋转的比色皿（18）的系统。 转子隔室（16）用作容器的解决方案，并且被设计和尺寸如在本领域中，颜色已经公知：如保留液体，当所述转子（16）是静止的，并与所述液体转移到比色皿（18） 当转子（16）旋转。 单个或多个光源（L）设置，其全部是以新颖的方式反mitted通过合适的装置的一个系统，特别是，光纤（30-35），以各个光电检测器单元（60至65），适当地与对齐的 试管（18）由相同数量的干涉滤光器（50至55）和适当的孔（40至45）位于所述转子（16）的基部（15）的手段的透明窗口。 因此，有可能为第一次确定的矿井，通过包含在在不同波长的比色皿（18）中，用波浪能抽样/样品加试剂/试剂的吸光度的化学溶液的浓度是从源（L）递送。 ... 因此，它可以检查一个以上的样本池（18）大致同时且单独地，每一个用于一个不同的分析参数，因此检查在最佳包含在比色杯中样品的透射率和/或吸光 波长。

公开(公告)号：EP0358250A3

公开(公告)日：1990-09-12

申请号：EP89201949.8

申请日：1989-07-25

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N27/416

CPC classification number: G01N27/4163 ,  Y10T436/102499

Abstract: A pre-determined amount of solubilized reagent is reacted to release CO₂ in a controlled-temperature reaction vessel and a controlled-pressure area adjacent the reaction vessel. The devices that enable the system to be maintained in the liquid phase, and the reaction vessel itself, are controlled, assuming that the O₂ in the solution is such as that deriving from the presence of O₂ in the atmosphere, if necessary corrected for the effect of the reaction producing CO₂. Thus, the amount of reagent taking part in the reaction being known, either by assay or by controlling the reaction time, by controlling the amount of O₂ in the solution containing the reagent, the barometric pressure, the temperature in the reaction vessel, and the coefficients of solubility of the two gases, it becomes possible to predict the partial pressures of O₂ and CO₂ in the liquid phase produced, which liquid phase is suitable for use as a calibration substance for an apparatus for measuring blood gases.

公开(公告)号：EP0355896A3

公开(公告)日：1990-09-12

申请号：EP89202034.8

申请日：1989-08-03

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calabrese, Gary Stephen ,  Calzi, Claudio

IPC: G01N27/416

CPC classification number: G01N27/4163

Abstract: Electrodes for the measurement of pCO2 and/or pO2 are calibrated with an exposed aliquot of a calibration liquid. A constituent such as a ferrioxalate salt in the calibration liquid is converted to the gas in a reproducible concentration by exposure of the aliquot to light. In some instances, the calibration liquid is equilibrated with air prior to exposure. Some mechanisms of light generation of carbon dioxide also consume oxygen, so as to depress the pO2 value by a reproducible amount. The use of two different calibration liquids enables both one-point and two-point calibration of the Clark oxygen electrode and the Severinghaus pCO2 electrode of a blood gas instrument. Aqueous acidic ferrioxalate compositions are disclosed for use as calibrants of pCO2 and of pO2 after photodecomposition. Compositions with high iron(III) to oxalate molar ratios (e.g., 5:1 to 100:1 with 0.3 to 15 millimolar oxalate) produce carbon dioxide on exposure without oxygen consumption. Compositions with low iron(III) to oxalate ratios (e.g., 1:1000 to 1:2000) with 0.1 to 5 millimolar iron(III) produce carbon dioxide on exposure with concurrent oxygen consumption. Use of the two types of compositions enables calibration values to be established with varying pCO2 values and with, respectively, high and low pO2 values.