公开(公告)号：US11554149B2

公开(公告)日：2023-01-17

申请号：US17035690

申请日：2020-09-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Seok Lee ,  Bong Geun Song ,  Sungdo Ha ,  Young Tae Park ,  Pilju Choi ,  Hoon Ryu

IPC: A61K36/185 ,  A23L33/105 ,  A61K8/9789 ,  A61K8/34 ,  A61K31/05 ,  B01J19/12

Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：US11458087B2

公开(公告)日：2022-10-04

申请号：US16893099

申请日：2020-06-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Sungdo Ha ,  Bong Chui Chung ,  Seok Lee ,  Pilju Choi ,  Bong Geun Song ,  Deok Ha Woo

IPC: A61K36/00 ,  A61K8/49 ,  A61K31/352 ,  A61K36/73 ,  A61K31/05

Abstract: Provided are a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through decarboxylic acid reaction by microwave irradiation of cannabis using various extraction solvents, and use of the processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：US11707444B2

公开(公告)日：2023-07-25

申请号：US17465847

申请日：2021-09-03

Applicant: RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jintae Lee ,  Jungyeob Ham ,  Taejung Kim

IPC: A61K31/352 ,  A61K31/192 ,  A61K31/05 ,  A61K31/513 ,  A61K31/4706 ,  A61P31/14 ,  A61K36/185 ,  G01N33/94 ,  G01N33/569 ,  A61K31/675

CPC classification number: A61K31/352 ,  A61K31/05 ,  A61K31/192 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/675 ,  A61K36/185 ,  A61P31/14 ,  G01N33/56983 ,  G01N33/948 ,  G01N2333/165 ,  G01N2500/04

Abstract: The present invention relates to an antiviral composition and a screening method thereof for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that occurred in Wuhan, China in 2019. An extract from leaves or unfertilized female flowers of Cannabis sativa L. or its fraction, and the cannabinoids (CBDs) molecules isolated from it have high binding strength and stability to SARS-CoV-2 MPpro, thereby inhibiting its action as the main protease, to provide a useful lead molecule that can be used alone or in combination with other drugs to treat SARS-CoV-2.

公开(公告)号：US11345667B2

公开(公告)日：2022-05-31

申请号：US16852820

申请日：2020-04-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Taejung Kim ,  Jungyeob Ham ,  Young Tae Park

IPC: C07D235/02

Abstract: The present invention relates to a method of preparing pactalactam represented by Formula 5 below using a total synthesis method: