公开(公告)号：US11717474B2

公开(公告)日：2023-08-08

申请号：US17138312

申请日：2020-12-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Jin-Chul Kim ,  Pilju Choi ,  Bong Geun Song

IPC: A61K36/00 ,  A61K8/49 ,  C07D311/80 ,  A23L33/105 ,  A23L5/30

CPC classification number: A61K8/498 ,  A23L5/34 ,  A23L33/105 ,  C07D311/80 ,  A23V2002/00 ,  A61K2236/333 ,  A61K2236/37

Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBN content in an efficient and economic manner, through cyclization of CBD and aromatization of THC by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBN content prepared by the method, a fraction thereof, and a single ingredient of CBN, in foods, drugs, and cosmetics.

公开(公告)号：US11058736B2

公开(公告)日：2021-07-13

申请号：US16549767

申请日：2019-08-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Jin-Chul Kim ,  Chang Geon Kim ,  Bong Geun Song ,  Taejung Kim ,  Pilju Choi ,  Seon-Jun Choi

IPC: A61K36/185 ,  A61P27/04 ,  A61K9/00

Abstract: Provided are a pharmaceutical composition for preventing or treating dry eye syndrome, including an extract of Terminalia chebula or a fraction thereof as an active ingredient, and a method of preventing or treating dry eye syndrome in an individual.

公开(公告)号：US10653732B2

公开(公告)日：2020-05-19

申请号：US15935634

申请日：2018-03-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Bong Chul Chung ,  Taejung Kim ,  Pilju Choi ,  Ki Sung Kang ,  Buyng Su Hwang ,  Kyu Sun Kim

IPC: A61K36/062 ,  A61P3/10 ,  A61K31/122 ,  A23L33/10 ,  A61K31/05 ,  C07C35/44 ,  C07C39/205 ,  C07C39/14

Abstract: Provided are a composition for stimulating insulin secretion from cells, the composition including a Hypoxylon truncatum extract or an active ingredient thereof, and a method of stimulating insulin secretion from cells.

公开(公告)号：US20200061137A1

公开(公告)日：2020-02-27

申请号：US16549767

申请日：2019-08-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Jin-Chul Kim ,  Chang Geon Kim ,  Bong Geun Song ,  Taejung Kim ,  Pilju Choi ,  Seon-Jun Choi

IPC: A61K36/185 ,  A61P27/04

Abstract: Provided are a pharmaceutical composition for preventing or treating dry eye syndrome, including an extract of Terminalia chebula or a fraction thereof as an active ingredient, and a method of preventing or treating dry eye syndrome in an individual.

公开(公告)号：US12083490B2

公开(公告)日：2024-09-10

申请号：US17590292

申请日：2022-02-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Taejung Kim ,  Jungyeob Ham ,  Young Tae Park ,  Pilju Choi ,  Joonyeon Chang

IPC: B01J19/12 ,  B01J19/24

CPC classification number: B01J19/126 ,  B01J19/243

Abstract: According to an aspect of the disclosure, there is provided a microwave reactor including a container for storing a bath fluid, a tube including an inlet at one end through which a target fluid is introduced, an outlet at another end through which the target fluid is discharged, wherein at least a portion of the tube is submerged in the bath fluid, and at least one radiator located outside the container and configured to irradiate microwaves into the container.

公开(公告)号：US11273192B2

公开(公告)日：2022-03-15

申请号：US16428626

申请日：2019-05-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Young Tae Park ,  Kyusun Kim ,  Pilju Choi ,  Seon-Jun Choi ,  Bong Geun Song ,  Jae Young Choi

IPC: A61K36/258 ,  A23L33/105 ,  A61K8/9789 ,  A61K31/704 ,  A61Q19/08 ,  A61K8/63

Abstract: Provided are a method of efficiently producing a ginseng leaf extract including rare ginsenosides Rg6, Rk3, and Rh4 in increased amounts, and use of a ginseng leaf extract produced by the method.

公开(公告)号：US10933033B2

公开(公告)日：2021-03-02

申请号：US16282203

申请日：2019-02-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Young Tae Park ,  Taejung Kim ,  Young seok Kim ,  Pilju Choi ,  Kyusun Kim ,  SeonJun Choi ,  BongGeun Song ,  Kisung Kang ,  Buyng Su Hwang ,  Dahae Lee ,  Jihoon Song

IPC: A61K31/122 ,  A61K33/243 ,  A61P13/12 ,  A61K36/062 ,  A61K31/05 ,  A61K31/09

Abstract: A composition for preventing or reducing nephrotoxicity, and use thereof are provided, the composition including a Hypoxylon truncatum extract or an active component thereof.

公开(公告)号：US10004776B2

公开(公告)日：2018-06-26

申请号：US15201819

申请日：2016-07-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Kwantae Kim ,  Pilju Choi ,  Buyng Su Hwang ,  Young Seok Kim

IPC: A61K36/00 ,  A61K36/258 ,  A61K9/00

CPC classification number: A61K36/258 ,  A61K9/00 ,  A61K2236/00

Abstract: Provided are a pharmaceutical composition for preventing or treating skin cancer and a method of preventing or treating skin cancer in a subject by using the pharmaceutical composition, wherein the pharmaceutical composition includes a Panax spp. plant extract as an active ingredient.

公开(公告)号：US11649221B2

公开(公告)日：2023-05-16

申请号：US16916920

申请日：2020-06-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Deok Ha Woo ,  Pilju Choi ,  Bong Geun Song

IPC: C07D311/80 ,  A61K8/49 ,  A61Q19/00 ,  B01D11/02 ,  A23L33/105

CPC classification number: C07D311/80 ,  A23L33/105 ,  A61K8/498 ,  A61Q19/00 ,  B01D11/0211 ,  B01D11/0288 ,  A23V2002/00 ,  A61K2800/10

Abstract: Provided are a method of preparing a cannabis processed product having an increased Δ9-THC content in an efficient and economic manner, through a cyclization reaction by microwave irradiation of cannabis using various extraction solvents, and use of the processed product having an increased Δ9-THC content prepared by the method, a fraction thereof, and a single ingredient of THC, in foods, drugs, and cosmetics.

公开(公告)号：US11618002B2

公开(公告)日：2023-04-04

申请号：US17221591

申请日：2021-04-02

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Young Tae Park ,  Pilju Choi

IPC: B01J19/12

Abstract: A large capacity natural material composition conversion apparatus using a microwave with a preset pressure function includes a chamber including a sealed reaction space accommodating a material, an radiator configured to heat the material by radiating a microwave into the reaction space, a pressure regulator configured to regulate a pressure of the reaction space by supplying a gas into the reaction space, and a controller configured to control the pressure regulator and the radiator, and preliminarily increase a pressure of the reaction space by controlling the pressure regulator before heating the material.