公开(公告)号：US20160231222A1

公开(公告)日：2016-08-11

申请号：US14615596

申请日：2015-02-06

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Ri Mi LEE ,  Dong Hyun JO ,  Jeong Hun KIM ,  Tae Geol LEE

IPC: G01N15/08 ,  G01N27/22

CPC classification number: G01N15/08 ,  G01N33/5064 ,  G01N2015/0853

Abstract: Provided is a method for screening drugs, more particularly, a method for screening drugs by measuring capacitance of an endothelial cell layer at a frequency region of 100 Hz to 5 kHz to screen a drug affecting paracellular permeability of the endothelial cell layer or a drug penetrating through a paracellular path.

Abstract translation: 本发明提供一种筛选药物的方法，更具体地，涉及一种通过测量在100Hz至5kHz的频率范围内的内皮细胞层的电容来筛选药物的方法，以筛选影响内皮细胞层的细胞外通透性的药物或穿透 通过细胞旁路。