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公开(公告)号：US20160231222A1
公开(公告)日：2016-08-11
申请号：US14615596
申请日：2015-02-06
Inventor： Ri Mi LEE , Dong Hyun JO , Jeong Hun KIM , Tae Geol LEE
CPC classification number: G01N15/08 , G01N33/5064 , G01N2015/0853
Abstract: Provided is a method for screening drugs, more particularly, a method for screening drugs by measuring capacitance of an endothelial cell layer at a frequency region of 100 Hz to 5 kHz to screen a drug affecting paracellular permeability of the endothelial cell layer or a drug penetrating through a paracellular path.
Abstract translation: 本发明提供一种筛选药物的方法，更具体地，涉及一种通过测量在100Hz至5kHz的频率范围内的内皮细胞层的电容来筛选药物的方法，以筛选影响内皮细胞层的细胞外通透性的药物或穿透 通过细胞旁路。
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公开(公告)号：US20190015348A1
公开(公告)日：2019-01-17
申请号：US15743895
申请日：2016-07-12
Applicant: SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION , KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
Inventor： Jeong Hun KIM , Dong Hyun JO , Tae Geol LEE
CPC classification number: A61K9/51 , A61K9/0048 , A61K9/146 , A61K9/16 , A61K9/5052 , A61K9/5169 , A61K33/00 , A61K33/24 , A61K38/385 , A61K47/42 , A61K47/6923 , A61K47/6925 , A61P27/00 , A61P27/02 , B82Y5/00 , B82Y30/00 , G01N33/15 , G01N33/50 , G01N33/68
Abstract: Provided is a nanoparticle-vitreous body-based protein complex, and more particularly, to a composition for inhibiting angiogenesis which includes the complex as an active ingredient, and a composition for preventing or treating an angiogenesis-related disease or a retinal disease. When the nanoparticle-vitreous body-based protein complex according to the subject matter is locally injected into the vitreous body, the complex exhibits significantly excellent binding strength with a vascular endothelial growth factor and thus can inhibit angiogenesis, thus being easily used to prepare a therapeutic agent for preventing, alleviating, or treating retinal and choroidal angiogenesis-related diseases.
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