公开(公告)号：US20150253243A1

公开(公告)日：2015-09-10

申请号：US14432066

申请日：2013-09-27

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Hyun Mo Cho ,  Yong Jai Cho ,  Won Chegal

IPC: G01N21/21 ,  G01N21/41

CPC classification number: G01N21/211 ,  G01N21/05 ,  G01N21/253 ,  G01N21/41 ,  G01N2201/06113 ,  G01N2201/0683

Abstract: An apparatus and method for simultaneously measuring, in an immersion microchannel environment, the characteristics of molecular junctions such as a low-molecular-weight biomaterial and the like and the refractive index of a buffer solution by using ellipsometry. Specifically, disclosed is an apparatus for simultaneously measuring, with high sensitivity, the change in refractive index of a buffer solution and the junction dynamic characteristics of a biomaterial by allowing polarized incident light to be received at a biomaterial adsorption layer, which is formed on a substrate such as a semiconductor and the like, so as to meet an anti-reflection condition of a P-wave by using a prism structure and a microchannel; and a measurement method using the same.

Abstract translation: 在浸入微通道环境中同时测量低分子量生物材料等分子结的特性以及使用椭偏仪测定缓冲溶液的折射率的装置和方法。 具体地说，公开了一种用于以高灵敏度同时测量缓冲溶液的折射率的变化和生物材料的结合动力学特性的装置，该方法是允许偏振的入射光被接收在生物材料吸附层上 基板如半导体等，以便通过使用棱镜结构和微通道来满足P波的抗反射条件; 以及使用其的测定方法。