公开(公告)号：WO1996039464A1

公开(公告)日：1996-12-12

申请号：PCT/US1996010249

申请日：1996-06-06

Applicant: C.R. BARD, INC. ,  LEHIGH UNIVERSITY

Inventor： C.R. BARD, INC. ,  LEHIGH UNIVERSITY ,  VANDERHOFF, John, W. ,  LU, Cheng, Xun ,  LEE, Clarence, C. ,  TSAI, Chi-Chun

IPC: C08J03/26

CPC classification number: C08J3/26 ,  C08J3/05 ,  C08J3/16 ,  C08J2300/14

Abstract: A process for the preparation of crosslinked water-soluble polymer particles comprising, combining an aqueous polymer solution comprising a water-soluble polymer, particularly a polysaccharide, and an aqueous medium, and an oil medium so as to form an emulsion of droplets of the water-soluble polymer, and adding to the emulsion a crosslinking agent capable of crosslinking the water-soluble polymer so as to form crosslinked water-soluble polymer particles, the particles formed thereby and aqueous dispersions thereof. The invention also encompasses a method comprising, administering to a patient in need of treatment an aqueous suspension of the water-soluble polymer particles.

Abstract translation: 一种制备交联的水溶性聚合物颗粒的方法，包括将包含水溶性聚合物，特别是多糖和含水介质的水性聚合物溶液和油介质混合，以形成水滴的乳液 并且向该乳液中添加能够使水溶性聚合物交联以形成交联的水溶性聚合物颗粒的交联剂，由此形成的颗粒及其水分散体。 本发明还包括一种方法，其包括向需要治疗的患者施用水溶性聚合物颗粒的水性悬浮液。

公开(公告)号：WO1991006011A1

公开(公告)日：1991-05-02

申请号：PCT/US1990006123

申请日：1990-10-23

Applicant: LEHIGH UNIVERSITY

Inventor： LEHIGH UNIVERSITY ,  ABEL, John, H. ,  OBREPALSKA-BIELSKA, Barbara

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2800/044 ,  Y10S435/962 ,  Y10S435/968 ,  Y10S436/811

Abstract: Two diagnostic methods for evaluating LDL metabolism in a patient are disclosed. A novel diagnostic agent for evaluating LDL metabolism comprising a ligand capable of binding LDL receptors and a fluorescent label and a diagnostic kit for evaluating LDL metabolism which utilized the specified diagnostic agent are also disclosed.

公开(公告)号：WO1990011832A1

公开(公告)日：1990-10-18

申请号：PCT/US1990001666

申请日：1990-03-30

Applicant: LEHIGH UNIVERSITY

Inventor： LEHIGH UNIVERSITY ,  SILEBI, Cesar, A. ,  DOS RAMOS, Jose

IPC: B03B05/00

CPC classification number: G01N30/0005 ,  B01D43/00 ,  B03B5/00 ,  G01N30/10 ,  G01N30/84 ,  G01N2030/885

Abstract: This invention provides an apparatus and method for the complete fractionation of submicron particles according to size by capillary hydrodynamic fractionation. This objective is achieved by using small diameter capillaries (18); introducing a minor fraction of a liquid dispersion of particles to be separated into at least one capillary fraction; passing the minor fraction through the capillary (18); and, at the exit of the capillary (18), diluting the minor fraction with the same liquid as is carrying the fractionated sample. These modifications in the flow patterns are essential to the use of capillaries (18) with diameters smaller than 60 microns. This invention is especially adapted for rapid analytical separation of not only rigid colloidal particles but also of soft latexes.

公开(公告)号：WO1990004401A1

公开(公告)日：1990-05-03

申请号：PCT/US1989004631

申请日：1989-10-23

Applicant: LEHIGH UNIVERSITY

Inventor： LEHIGH UNIVERSITY ,  REGEN, Steven, L.

IPC: A61K31/74

CPC classification number: C08G18/4833 ,  A61K31/74 ,  C08G18/5024 ,  C08G63/672 ,  C08G63/676 ,  C08G63/68 ,  C08G64/02 ,  C08G69/08 ,  C11D1/008 ,  Y10S514/844

Abstract: An amphiphilic polymer, having the monomer unit structure (A), (B), (C) or (D) wherein R is at least one of H and C1-6 alkyl, k = 1-4, m = 4-30, n = 2-50, and x = 2-500; (B) and (C) wherein p and q are, independently, 0-22, and the sum of p and q is 4-44; (D) wherein r and s are, independently, 0-22, and the sum of r and s is in the range 2-44, Ar is a divalent aromatic radical; and compounds in which the ester group in compounds (A), (B), (C) and (D) is replaced by an amide, urea, urethane, ether, or carbonate. These compounds are useful for disrupting lipid membranes, as surfactants and dispersing agents and in the treatment of viral, bacterial and fungal diseases.