公开(公告)号：WO2009142976A3

公开(公告)日：2010-01-07

申请号：PCT/US2009043781

申请日：2009-05-13

Applicant: LI COR INC ,  BOUZID AHMED ,  LAMB DONALD T ,  RAGATZ ANDREW G ,  MIDDENDORF LYLE R

Inventor： BOUZID AHMED ,  LAMB DONALD T ,  RAGATZ ANDREW G ,  MIDDENDORF LYLE R

IPC: F21V5/00

CPC classification number: G01J3/10 ,  A61B5/0071 ,  G01J3/0208 ,  G01J3/12 ,  G01J3/4406 ,  G01J2003/104 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01N21/6456

Abstract: An optical system is disclosed that can be used for fluorescence filtering for molecular imaging. In one preferred embodiment, a source subsystem is disclosed comprising a light source and a first set of filters designed to pass wavelengths of light in an absorption band of a fluorescent material. A detector subsystem is also disclosed comprising a light detector, imaging optics, a second set of filters designed to pass wavelengths of light in an emission band of the fluorescent material, and an aperture located at a front focal plane of the imaging optics. A telecentric space is created between the light detector and the imaging optics, such that axial rays from a plurality of field points emerge from the imaging optics parallel to each other and perpendicular to the second set of filters.

Abstract translation: 公开了可用于分子成像的荧光过滤的光学系统。 在一个优选实施例中，公开了一种源子系统，其包括光源和被设计为通过荧光材料的吸收带中的光的波长的第一组滤光器。 还公开了一种检测器子系统，其包括光检测器，成像光学器件，被设计为通过荧光材料的发射带中的光的波长的第二组滤光器，以及位于成像光学器件的前焦平面处的孔。 在光检测器和成像光学器件之间产生远心空间，使得来自多个场点的轴向射线从成像光学器件彼此平行并垂直于第二组滤光器出射。