公开(公告)号：WO2009142976A2

公开(公告)日：2009-11-26

申请号：PCT/US2009/043781

申请日：2009-05-13

Applicant: LI-COR, INC. ,  BOUZID, Ahmed ,  LAMB, Donald, T. ,  RAGATZ, Andrew, G. ,  MIDDENDORF, Lyle, R.

Inventor： BOUZID, Ahmed ,  LAMB, Donald, T. ,  RAGATZ, Andrew, G. ,  MIDDENDORF, Lyle, R.

IPC: G02B27/20 ,  F21S8/00 ,  G01J1/58

CPC classification number: G01J3/10 ,  A61B5/0071 ,  G01J3/0208 ,  G01J3/12 ,  G01J3/4406 ,  G01J2003/104 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01N21/6456

Abstract: An optical system is disclosed that can be used for fluorescence filtering for molecular imaging. In one preferred embodiment, a source subsystem is disclosed comprising a light source and a first set of filters designed to pass wavelengths of light in an absorption band of a fluorescent material. A detector subsystem is also disclosed comprising a light detector, imaging optics, a second set of filters designed to pass wavelengths of light in an emission band of the fluorescent material, and an aperture located at a front focal plane of the imaging optics. A telecentric space is created between the light detector and the imaging optics, such that axial rays from a plurality of field points emerge from the imaging optics parallel to each other and perpendicular to the second set of filters

Abstract translation: 公开了可用于分子成像的荧光过滤的光学系统。 在一个优选实施例中，公开了一种源子系统，其包括光源和被设计为通过荧光材料的吸收带中的光的波长的第一组滤光器。 还公开了一种检测器子系统，其包括光检测器，成像光学器件，被设计为通过荧光材料的发射带中的光的波长的第二组滤光器，以及位于成像光学器件的前焦平面处的孔。 在光检测器和成像光学器件之间产生远心空间，使得来自多个场点的轴向光线从成像光学器件彼此平行并垂直于第二组滤光器

公开(公告)号：WO2011146900A1

公开(公告)日：2011-11-24

申请号：PCT/US2011/037456

申请日：2011-05-20

Applicant: LI-COR, INC. ,  PIEPER, Sean ,  BOUZID, Ahmed ,  LAMB, Donald T. ,  RAGATZ, Andrew G.

Inventor： PIEPER, Sean ,  BOUZID, Ahmed ,  LAMB, Donald T. ,  RAGATZ, Andrew G.

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N2201/064 ,  G01N2201/0642

Abstract: A fluorescence imaging system having an enclosure having an optical excitation and detection system and features designed to suppress or reduce background fluorescence. In certain aspects, all or a portion of the interior walls has a material finish and texture that provides a surface that absorbs at least a portion of any impinging excitation light and which has low auto-fluorescing properties. In certain aspects, a baffle structure is provided on the interior of the structure and is configured to mask portions of the interior and reduce the opening through which light impinges on the detector. In certain aspects, a platform having an optically transparent window is located in the interior of the housing structure for holding a sample for excitation by excitation light from an excitation source, wherein a light-trap structure is positioned or located on an opposite side of the platform relative to the excitation source and configured to receive and contain a substantial portion of any scattered or transmitted excitation light.

Abstract translation: 一种荧光成像系统，其具有具有光学激发和检测系统的外壳和被设计为抑制或减少背景荧光的特征。 在某些方面，内壁的全部或一部分具有提供吸收至少一部分任何入射激发光并且具有低自发荧光特性的表面的材料表面和纹理。 在某些方面，挡板结构设置在结构的内部，并且构造成掩盖内部的一部分并且减小光照射在检测器上的开口。 在某些方面，具有光学透明窗口的平台位于壳体结构的内部，用于通过来自激发源的激发光来保持用于激发的样品，其中光阱结构被定位或位于 平台相对于激发源并且被配置为接收和容纳任何散射或透射的激发光的实质部分。

公开(公告)号：WO2009142976A3

公开(公告)日：2010-01-07

申请号：PCT/US2009043781

申请日：2009-05-13

Applicant: LI COR INC ,  BOUZID AHMED ,  LAMB DONALD T ,  RAGATZ ANDREW G ,  MIDDENDORF LYLE R

Inventor： BOUZID AHMED ,  LAMB DONALD T ,  RAGATZ ANDREW G ,  MIDDENDORF LYLE R

IPC: F21V5/00

CPC classification number: G01J3/10 ,  A61B5/0071 ,  G01J3/0208 ,  G01J3/12 ,  G01J3/4406 ,  G01J2003/104 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01N21/6456

Abstract: An optical system is disclosed that can be used for fluorescence filtering for molecular imaging. In one preferred embodiment, a source subsystem is disclosed comprising a light source and a first set of filters designed to pass wavelengths of light in an absorption band of a fluorescent material. A detector subsystem is also disclosed comprising a light detector, imaging optics, a second set of filters designed to pass wavelengths of light in an emission band of the fluorescent material, and an aperture located at a front focal plane of the imaging optics. A telecentric space is created between the light detector and the imaging optics, such that axial rays from a plurality of field points emerge from the imaging optics parallel to each other and perpendicular to the second set of filters.

Abstract translation: 公开了可用于分子成像的荧光过滤的光学系统。 在一个优选实施例中，公开了一种源子系统，其包括光源和被设计为通过荧光材料的吸收带中的光的波长的第一组滤光器。 还公开了一种检测器子系统，其包括光检测器，成像光学器件，被设计为通过荧光材料的发射带中的光的波长的第二组滤光器，以及位于成像光学器件的前焦平面处的孔。 在光检测器和成像光学器件之间产生远心空间，使得来自多个场点的轴向射线从成像光学器件彼此平行并垂直于第二组滤光器出射。