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    METHODS AND APPARATUS FOR MEASURING ANALYTES
    12.
    发明申请
    METHODS AND APPARATUS FOR MEASURING ANALYTES 审中-公开
    测量分析仪的方法和装置

    公开(公告)号：WO2012036679A1

    公开(公告)日：2012-03-22

    申请号：PCT/US2010/048835

    申请日：2010-09-15

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  ROTHBERG, Johnathan ,  REARICK, Todd

    Inventor： ROTHBERG, Johnathan ,  REARICK, Todd

    IPC: H01L31/0232

    CPC classification number: G01N27/4145 ,  C12Q1/6874 ,  G01N27/4148

    Abstract: Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by- synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

    Abstract translation: 涉及FET阵列的方法和装置，包括用于监测化学和/或生物反应的大型FET阵列，例如通过合成反应的核酸测序。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。

    APPARATUS AND METHOD FOR FLUID POTENTIAL ARTIFACT CORRECTION IN REAGENT DELIVERY SYSTEMS COMPRISING A SENSOR ARRAY
    14.
    发明公开
    APPARATUS AND METHOD FOR FLUID POTENTIAL ARTIFACT CORRECTION IN REAGENT DELIVERY SYSTEMS COMPRISING A SENSOR ARRAY 审中-公开

    公开(公告)号：EP4246138A2

    公开(公告)日：2023-09-20

    申请号：EP23187427.2

    申请日：2015-09-14

    Applicant: Life Technologies Corporation

    Inventor： WONG, Chiu Tai Andrew ,  REARICK, Todd ,  DONOHUE, John

    IPC: G01N27/414

    Abstract: A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or disturbances.

    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS
    17.
    发明公开
    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS 审中-公开

    公开(公告)号：EP3582224A1

    公开(公告)日：2019-12-18

    申请号：EP19162210.9

    申请日：2011-12-29

    Applicant: Life Technologies Corporation

    Inventor： REARICK, Todd ,  SCHULTZ, Jonathan

    IPC: G16B40/10 ,  G16B30/20 ,  C12Q1/6869

    Abstract: Mathematical models for the analysis of signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the measured output signal from the reaction confinement region of a reactor array is mathematically modeled. The output signal may be modeled as a linear combination of one or more signal components, including a background signal component. This model is solved to determine the nucleotide incorporation signal. In another embodiment, the incorporation signal from the reaction confinement region of a reactor array is mathematically modeled.

    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS
    18.
    发明公开
    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS 审中-公开
    模型数据从测序-BY-合成操作分析

    公开(公告)号：EP2658999A2

    公开(公告)日：2013-11-06

    申请号：EP11811287.9

    申请日：2011-12-29

    Applicant: Life Technologies Corporation

    Inventor： REARICK, Todd ,  SCHULTZ, Jonathan

    IPC: C12Q1/68 ,  G06F17/10 ,  C40B30/00

    CPC classification number: G06F19/24 ,  C12Q1/6869 ,  C12Q2527/119 ,  C12Q2563/159 ,  C12Q2565/607

    Abstract: Mathematical models for the analysis of signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the measured output signal from the reaction confinement region of a reactor array is mathematically modeled. The output signal may be modeled as a linear combination of one or more signal components, including a background signal component. This model is solved to determine the nucleotide incorporation signal. In another embodiment, the incorporation signal from the reaction confinement region of a reactor array is mathematically modeled.

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