公开(公告)号：HK1056897A1

公开(公告)日：2004-03-05

申请号：HK03108750

申请日：2003-12-01

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N20060101 ,  G01N21/64 ,  C12M20060101 ,  C12M1/34 ,  C12Q20060101 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.

公开(公告)号：CA2799371A1

公开(公告)日：2002-08-29

申请号：CA2799371

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD H ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N21/64 ,  G01N33/567 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.