公开(公告)号：AU2002256992B2

公开(公告)日：2007-06-07

申请号：AU2002256992

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HOLLIS MARK ALEXANDER ,  NARGI FRANCES ELLEN ,  MATHEWS RICHARD HART ,  VIAN TRINA RAE ,  MENDENHALL LINDA MARIE ,  RUNDELL ANN ,  SCHWOEBEL ERIC DAVID ,  JOHNSON BERNADETTE ,  RIDER TODD HARRISON ,  PETROVICK MARTHA SUSAN ,  YOUNG ALBERT M ,  HARPER JAMES DOUGLAS ,  STEPHENS TIMOTHY

IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.

公开(公告)号：EP1364070A4

公开(公告)日：2004-03-17

申请号：EP02726568

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  G01N33/50 ,  C12M1/28 ,  C12Q1/02 ,  C12Q1/24

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

公开(公告)号：AT345497T

公开(公告)日：2006-12-15

申请号：AT02726568

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  G01N33/50 ,  C12Q1/02 ,  C12Q1/24 ,  C12M1/28

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.

公开(公告)号：CA2437033A1

公开(公告)日：2002-08-29

申请号：CA2437033

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： JOHNSON BERNADETTE ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  RUNDELL ANN ,  HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  PETROVICK MARTHA SUSAN ,  YOUNG ALBERT M ,  HOLLIS MARK ALEXANDER ,  NARGI FRANCES ELLEN ,  MENDENHALL LINDA MARIE ,  STEPHENS TIMOTHY ,  VIAN TRINA RAE

IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  C12Q1/68 ,  H01L29/00 ,  H01L21/203 ,  G01N27/26 ,  G01N33/552 ,  G01N33/554

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

公开(公告)号：CA2437033C

公开(公告)日：2013-04-02

申请号：CA2437033

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N21/64 ,  G01N33/567 ,  C12M1/34 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C40B30/04 ,  C40B40/02 ,  C40B60/00 ,  G01N1/36 ,  G01N15/10 ,  G01N21/76 ,  G01N21/77 ,  G01N21/78 ,  G01N33/52 ,  G01N33/53 ,  G01N33/543 ,  G01N33/554 ,  G01N33/569 ,  G01N33/58

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

公开(公告)号：DE60239837D1

公开(公告)日：2011-06-01

申请号：DE60239837

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N21/64 ,  G01N33/50 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

公开(公告)号：HK1056897A1

公开(公告)日：2004-03-05

申请号：HK03108750

申请日：2003-12-01

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N20060101 ,  G01N21/64 ,  C12M20060101 ,  C12M1/34 ,  C12Q20060101 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.

公开(公告)号：AT506452T

公开(公告)日：2011-05-15

申请号：AT06022907

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: C12Q1/04 ,  G01N21/64 ,  C12M1/34 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.

公开(公告)号：HK1135187A1

公开(公告)日：2010-05-28

申请号：HK10103373

申请日：2010-04-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETTE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N20060101 ,  G01N21/64 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.

公开(公告)号：BR0207084A

公开(公告)日：2004-01-20

申请号：BR0207084

申请日：2002-02-06

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： HARPER JAMES DOUGLAS ,  MATHEWS RICHARD HART ,  JOHNSON BERNADETE ,  PETROVICK MARTHA SUSAN ,  RUNDELL ANN ,  NARGI FRANCES ELLEN ,  STEPHENS TIMOTHY ,  MENDENHALL LINDA MARIE ,  HOLLIS MARK ALEXANDER ,  YOUNG ALBERT M ,  RIDER TODD HARRISON ,  SCHWOEBEL ERIC DAVID ,  VIAN TRINA RAE

IPC: G01N21/64 ,  C12M1/34 ,  C12Q1/04 ,  G01N1/36 ,  G01N21/77 ,  G01N21/78 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  C12Q1/68 ,  G01N27/26 ,  G01N33/552 ,  G01N33/554 ,  H01L21/203 ,  H01L29/00

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.