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公开(公告)号：AT540984T
公开(公告)日：2012-01-15
申请号：AT05851973
申请日：2005-11-18
Applicant: MAYO FOUNDATION
Inventor： WANG SHANGFENG , YASZEMSKI MICHAEL , LU LICHUN , CURRIER BRADFORD
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12.发明专利
公开(公告)号：ES2345108T3
公开(公告)日：2010-09-15
申请号：ES04777241
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , CURRIER BRADFORF L , JABBARI ESMAIEL , LU LICHUN
Abstract: Una composición que comprende: un macrómero que incluye unidades de silano, unidades derivadas de un diácido insaturado que cuenta con un doble enlace carbono-carbono, y unidades derivadas de un diácido saturado; y un componente cerámico bioactivo injertado al macrómero.
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公开(公告)号：DE602004026593D1
公开(公告)日：2010-05-27
申请号：DE602004026593
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , CURRIER BRADFORF L , JABBARI ESMAIEL , LU LICHUN
Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
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公开(公告)号：AU2006242487A1
公开(公告)日：2006-11-09
申请号：AU2006242487
申请日：2006-04-28
Applicant: MAYO FOUNDATION
Inventor： WANG SHANFENG , YASZEMSKI MICHAEL J , LU LICHUN
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公开(公告)号：CA2528092A1
公开(公告)日：2005-03-03
申请号：CA2528092
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , JABBARI ESMAIEL , LU LICHUN , CURRIER BRADFORF L
Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacti ng an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
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Patent Agency Ranking
公开(公告)号：CA2528150A1
公开(公告)日：2005-01-20
申请号：CA2528150
申请日：2004-06-29
Applicant: MAYO FOUNDATION
Inventor： YASZEMSKI MICHAEL J , CURRIER BRADFORD L , LU LICHUN , JABBARI ESMAIEL
IPC: C08F224/00 , A61B17/68 , A61K20060101 , A61L27/14 , A61L27/58 , C08F290/00 , C08G63/08 , C08G63/91 , C08J9/26 , C08L67/04
Abstract: Fumaric acid or a salt thereof, such as a fumaryl halide (e.g., fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with a biodegradable poly(caprolactone) macromer that has a flexible backbone such that the resulting copolymer may self-crosslink in the absence of a crosslinking agen t. The biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction.
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公开(公告)号：DE602004018163D1
公开(公告)日：2009-01-15
申请号：DE602004018163
申请日：2004-08-27
Applicant: MAYO FOUNDATION
Inventor： JABBARI ESMAIEL , YASZEMSKI MICHAEL J , CURRIER BRADFORD L , LU LICHUN
Abstract: Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).
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公开(公告)号：CA2606396A1
公开(公告)日：2006-11-09
申请号：CA2606396
申请日：2006-04-28
Applicant: MAYO FOUNDATION
Inventor： WANG SHANFENG , LU LICHUN , YASZEMSKI MICHAEL J
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19.发明专利
公开(公告)号：CA2602905A1
公开(公告)日：2006-09-28
申请号：CA2602905
申请日：2006-03-23
Applicant: MAYO FOUNDATION
Inventor： LU LICHUN , DADSETAN MAHROKH , YASZEMSKI MICHAEL
IPC: C08F283/01 , A61L31/06 , A61L31/14 , C08F26/08 , C08G63/676 , C08J3/24 , C08J3/28 , C08L51/08 , C08L67/06
Abstract: The invention provides photocrosslinkable, injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels made from the photopolymerization of an OPF macromer with UV light and a photoinitiator. Hydrogels with varying mechanical properties and water content can be made with changes in macromer and crosslinking agent concentration in a precursor solution. The biodegradable OPF hydrogels can be injected as a fluid into a bodily defect of any shape, may incorporate various therapeutic agents, e.g., cells and/or growth factors, and may be implanted via minimally invasive arthroscopic techniques.
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公开(公告)号：CA2587308A1
公开(公告)日：2006-05-18
申请号：CA2587308
申请日：2005-11-10
Applicant: MAYO FOUNDATION
Inventor： LU LICHUN , WANG SHANGFENG , YASZEMSKI MICHAEL J
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