公开(公告)号：EP3386955A1

公开(公告)日：2018-10-17

申请号：EP16810077.4

申请日：2016-12-08

Applicant: Novartis AG

Inventor： KLEINBECK-RINIKER, Florian Karl ,  MARTIN, Benjamin ,  PENN, Gerhard ,  VENTURONI, Francesco ,  SCHLAMA, Thierry ,  RUCH, Thomas ,  ALLMENDINGER, Thomas ,  WIETFELD, Bernhard ,  FILIPPONI, Paolo

IPC: C07D267/02 ,  C07D207/36 ,  C07C57/46

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：EP3386955B1

公开(公告)日：2020-08-05

申请号：EP16810077.4

申请日：2016-12-08

Applicant: Novartis AG

Inventor： KLEINBECK-RINIKER, Florian Karl ,  MARTIN, Benjamin ,  PENN, Gerhard ,  VENTURONI, Francesco ,  SCHLAMA, Thierry ,  RUCH, Thomas ,  ALLMENDINGER, Thomas ,  WIETFELD, Bernhard ,  FILIPPONI, Paolo

IPC: C07C251/66 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07C69/738

公开(公告)号：EP3823963A2

公开(公告)日：2021-05-26

申请号：EP19782697.7

申请日：2019-07-15

Applicant: Novartis AG

Inventor： FU, Peng ,  GAI, Yu ,  GAO, Feng ,  KONG, Weiyong ,  LU, Yadong ,  MIN, Zhongcheng ,  RONG, Shaofeng ,  SHU, Chutian ,  WANG, Can ,  WANG, Ruidong ,  ZHAO, Jibin ,  ZHAO, Xianglin ,  ZHAO, Yi ,  ZHOU, Jianguang ,  MARTIN, Benjamin

IPC: C07D401/06

公开(公告)号：EP2313390B1

公开(公告)日：2012-09-19

申请号：EP09781555.9

申请日：2009-08-06

Applicant: Novartis AG

Inventor： MARTIN, Benjamin

IPC: C07D401/04 ,  A61K39/385 ,  A61P25/34

CPC classification number: C07D401/04 ,  A61K39/0013

公开(公告)号：EP2313390A1

公开(公告)日：2011-04-27

申请号：EP09781555.9

申请日：2009-08-06

Applicant: Novartis AG

Inventor： MARTIN, Benjamin

IPC: C07D401/04 ,  A61K39/385 ,  A61P25/34

CPC classification number: C07D401/04 ,  A61K39/0013

Abstract: A process for preparing a nicotine-based hapten of formula (I) or a salt or solvate thereof, wherein n, R
1 and R
2 have the meanings as indicated in the specification. The nicotine-based hapten forms part of a smoking cessation vaccine.

公开(公告)号：EP3500549A1

公开(公告)日：2019-06-26

申请号：EP17768866.0

申请日：2017-08-16

Applicant: Novartis AG

Inventor： MARTIN, Benjamin ,  KLEINBECK-RINIKER, Florian Karl ,  PENN, Gerhard ,  VENTURONI, Francesco ,  SEDELMEIER, Joerg ,  SEDELMEIER, Gottfried ,  MAFLI, Ives

IPC: C07C67/38 ,  C07C69/738 ,  C07C201/06 ,  C07C201/12 ,  C07C201/16 ,  C07C205/51 ,  C07C205/53 ,  C07C227/18 ,  C07C231/02 ,  C07C249/08 ,  C07C251/38 ,  C07C269/00 ,  C07C271/22 ,  C07D207/12 ,  C07D213/36

公开(公告)号：EP3256444A1

公开(公告)日：2017-12-20

申请号：EP16704711.7

申请日：2016-02-11

Applicant: Novartis AG

Inventor： MARTIN, Benjamin ,  MANDRELLI, Francesca ,  VENTURONI, Francesco

IPC: C07C201/12 ,  C07C227/04 ,  C07C335/16

CPC classification number: C07C201/10 ,  B01J31/0237 ,  B01J31/0241 ,  B01J31/0244 ,  B01J31/0265 ,  C07B2200/07 ,  C07C201/12 ,  C07C205/04 ,  C07C205/44 ,  C07C205/51 ,  C07C227/04 ,  C07C335/16 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/06 ,  C07F7/1804 ,  C07F9/5355 ,  C07C205/53 ,  C07C229/34

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：EP4536822A1

公开(公告)日：2025-04-16

申请号：EP23744230.6

申请日：2023-06-08

Applicant: Novartis AG

Inventor： ALVIZO, Oscar ,  LUESCHER, Michael Umberto ,  MANN, Gregory ,  MARTIN, Benjamin ,  NOVICK, Scott J. ,  Ó MEADHRA, Ruairí Seosamh ,  PESCHKE, Theo ,  SCHLAMA, Thierry ,  SCHOBER, Lukas Christian ,  SCHROER, Kirsten ,  STANGER, Frederic ,  SUBRAMANIAN, Nandhitha ,  TRUNG, Nhat Quang Nguyen

IPC: C12N9/88