COMPOSITIONS ANTI-SEBORRHEIQUES ET ANTIACNEIQUES

    公开(公告)号:CA965008A

    公开(公告)日:1975-03-25

    申请号:CA88893

    申请日:1970-07-22

    Applicant: OREAL

    Abstract: 1310559 Pyridoxine derivatives L'OREAL 23 July 1970 [23 July 1969] 35797/70 Heading C2C [Also in Divisions A5, C4 and D1] Dermatological compounds II (including salts thereof) where R signifies an organic radical containing at least one amine group and optionally a carboxylic acid, ester or amide group and wherein the amine group may be substituted by an acyl or sulphonyl radical or by one or two alkyl radicals which can contain acid, ester, amide, amine, alcohol or guanidine groups (R signifies, e.g. -CH 2 CH 2 NH 2 or -CH 2 CHNH 2 CO 2 H), are made: (a) by converting pyridoxine hydrochloride into a ketal (i.e. the phenolic hydroxy in the 3-position and the alcohol group in the 4- position are blocked by ketalization, utilizing, e.g. acetone), thereafter chlorinating the 5- hydroxymethyl group to afford the corresponding 5-chloromethyl compound, which is, in turn, reacted with a thiol or alkali metal thiolate, A.S.R (A is H or an alkali metal atom) and subsequently hydrolysing the product so obtained to remove the protecting ketal group, or (b) by reacting R.halogen with an appropriate thiol derived from pyridoxine.

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