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    5.
    发明专利
    未知

    公开(公告)号：AT306242B

    公开(公告)日：1973-03-26

    申请号：AT668870

    申请日：1970-07-22

    Applicant: OREAL

    Inventor： KALOPISSIS GREGOIRE ING ,  BOUILLON CLAUDE DR ING ,  MANOUSSOS GEORGES ,  BERREBI CLAUDINE

    IPC: A61K8/67 ,  A61K31/44 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  C07D213/66 ,  C07D491/04 ,  C11D1/00 ,  A61K7/00

    Abstract: 1310559 Pyridoxine derivatives L'OREAL 23 July 1970 [23 July 1969] 35797/70 Heading C2C [Also in Divisions A5, C4 and D1] Dermatological compounds II (including salts thereof) where R signifies an organic radical containing at least one amine group and optionally a carboxylic acid, ester or amide group and wherein the amine group may be substituted by an acyl or sulphonyl radical or by one or two alkyl radicals which can contain acid, ester, amide, amine, alcohol or guanidine groups (R signifies, e.g. -CH 2 CH 2 NH 2 or -CH 2 CHNH 2 CO 2 H), are made: (a) by converting pyridoxine hydrochloride into a ketal (i.e. the phenolic hydroxy in the 3-position and the alcohol group in the 4- position are blocked by ketalization, utilizing, e.g. acetone), thereafter chlorinating the 5- hydroxymethyl group to afford the corresponding 5-chloromethyl compound, which is, in turn, reacted with a thiol or alkali metal thiolate, A.S.R (A is H or an alkali metal atom) and subsequently hydrolysing the product so obtained to remove the protecting ketal group, or (b) by reacting R.halogen with an appropriate thiol derived from pyridoxine.

    Compositions for the Treatment of the Scalp and their Preparation
    7.
    发明专利
    Compositions for the Treatment of the Scalp and their Preparation 未知

    公开(公告)号：GB1198005A

    公开(公告)日：1970-07-08

    申请号：GB1430568

    申请日：1968-03-25

    Applicant: OREAL

    Inventor： BERREBI CLAUDINE ,  MANOUSSOS GEORGES

    IPC: A61K8/98 ,  A61Q7/00

    Abstract: 1,198,005. Foetal extracts; cosmetic compositions. L'OREAL. 25 March, 1968 [24 March, 1967], No. 14305/68. Heading A5B. Cutaneous teguments and/or tissues of the umbilical cord are removed from bovine or ovine foetuses and an active product is extracted therefrom with an aqueous ion-containing solution at a temperature not exceeding 4‹C., the resultant solution optionally being digested with a proteolytic enzyme e.g. pronase, papain, pepsin or trypsin, without delipidation, and the active product being recovered from the solution. The ion-containing solution may be an aqueous solution of neutral salts such as NaCl, KCl, LiCl, CaCl 2 and MgCl 2 ; acid salts such as K or Na phosphates or citrates; acids such as HCl, H 2 SO 4 and acetic acid; bases such as K, Na, NH 4 , Ca or Ba hydroxides; or of ionisable organic compounds such as urea or phenol. Preferably the foetal tissues are frozen and ground in the ion-containing solution which is then centrifuged, and the supernatant liquid containing the active product is separated by dialysis with distilled water, or by precipitation by the addition of absolute alcohol, then a mixture of alcohol and ether and then ether, the alcohol preferably containing K, Na, Ca, Ba or Zn acetate. Any mucosaccharides present in the supernatant liquid after centrifuging may be precipitated by addition of phosphotungstic acid. Cosmetic compositions for combatting falling out of hair comprise the active product and a cosmetic carrier or excipient and may be in the form of aqueous solutions, emulsions, creams or gels. The compositions may also comprise a dye, perfume, penetrating agent, emulsifying agent, anti-seborrhoeic agent, a known substance for combatting the falling out of hair and/or a preservative e.g. sodium merthiolate, hexachlorophene or an oxidised derivative of a benzoate. Methionine, vitamin E, inositol, salicyclic acid, lactic acid, allantoin and/or choline or its citrate may be present in the compositions.

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