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    PURINONE COMPOUNDS AS KINASE INHIBITORS
    11.
    发明专利
    PURINONE COMPOUNDS AS KINASE INHIBITORS 未知

    公开(公告)号：PH12014501815B1

    公开(公告)日：2014-11-17

    申请号：PH12014501815

    申请日：2014-07-31

    Applicant: PHARMACYCLICS INC

    Inventor： CHEN WEI ,  LOURY DAVID J ,  YAN SHUNQI ,  WANG LONGCHENG ,  FRYE LEAH LYNN

    IPC: A61K31/52 ,  A61P35/00 ,  A61P37/00 ,  C07D473/32

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    Purinone compounds as kinase inhibitors
    12.
    发明专利
    Purinone compounds as kinase inhibitors 未知

    公开(公告)号：AU2013215166A1

    公开(公告)日：2014-08-28

    申请号：AU2013215166

    申请日：2013-01-30

    Applicant: PHARMACYCLICS INC

    Inventor： CHEN WEI ,  LOURY DAVID J ,  YAN SHUNQI ,  WANG LONGCHENG ,  FRYE LEAH LYNN

    IPC: C07D473/32 ,  A61K31/52 ,  A61P35/00 ,  A61P37/00

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase
    13.
    发明专利
    Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase 未知

    公开(公告)号：MA38183A1

    公开(公告)日：2017-03-31

    申请号：MA38183

    申请日：2013-11-14

    Applicant: PHARMACYCLICS INC

    Inventor： CHEN WEI ,  LOURY DAVID J ,  WANG LONGCHENG

    IPC: A61K31/519 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D487/04

    Abstract: La présente invention concerne des composés qui forment des liaisons covalentes avec la tyrosine kinase de bruton (btk). L'invention concerne également des inhibiteurs irréversibles de btk. De plus, l'invention concerne également des inhibiteurs réversibles de btk. L'invention concerne également des compositions pharmaceutiques qui comprennent les composés. L'invention concerne des procédés d'utilisation des inhibiteurs de btk, seuls en combinaison avec d'autres agents thérapeutiques, pour le traitement de maladies auto-immunes ou d'états auto-immuns, de maladies hétéro-immunes ou d'états hétéro-immuns, le cancer, comprenant un lymphome, et des maladies ou états inflammatoires.

    PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
    15.
    发明专利
    PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS 未知

    公开(公告)号：CA2890934A1

    公开(公告)日：2014-05-22

    申请号：CA2890934

    申请日：2013-11-14

    Applicant: PHARMACYCLICS INC

    Inventor： CHEN WEI ,  LOURY DAVID J ,  WANG LONGCHENG

    IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    PURINONE COMPOUNDS AS KINASE INHIBITORS
    16.
    发明专利
    PURINONE COMPOUNDS AS KINASE INHIBITORS 未知

    公开(公告)号：CA2863140C

    公开(公告)日：2016-10-18

    申请号：CA2863140

    申请日：2013-01-30

    Applicant: PHARMACYCLICS INC

    Inventor： YAN SHUNQI ,  WANG LONGCHENG ,  FRYE LEAH LYNN ,  CHEN WEI ,  LOURY DAVID J

    IPC: C07D473/34 ,  A61K31/522 ,  A61P37/06

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    COMPUESTOS DE PURINONA COMO INHIBIDORES DE QUINASAS.
    20.
    发明专利
    COMPUESTOS DE PURINONA COMO INHIBIDORES DE QUINASAS. 未知

    公开(公告)号：MX2014009219A

    公开(公告)日：2015-02-05

    申请号：MX2014009219

    申请日：2013-01-30

    Applicant: PHARMACYCLICS INC

    Inventor： YAN SHUNQI ,  CHEN WEI ,  LOURY DAVID J ,  WANG LONGCHENG ,  FRYE LEAH LYNN

    IPC: C07D473/32 ,  A61K31/52 ,  A61P35/00 ,  A61P37/00

    Abstract: Se describen en el presente documento compuestos que forman enlaces covalentes con la tirosina quinasa de Bruton (Btk). También se describen inhibidores irreversibles de Btk. Además, también se describen inhibidores reversibles de Btk. También se describen composiciones farmacéuticas que incluyen los compuestos. Se describen métodos para utilizar los inhibidores de Bkt, solos junto con otros agentes terapéuticos, para el tratamiento de dolencias o enfermedades autoinmunes, enfermedades o dolencias heteroinmunes, cáncer, incluyendo linfoma, y enfermedades o dolencias inflamatorias.

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