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公开(公告)号：JP2013253089A
公开(公告)日：2013-12-19
申请号：JP2013160858
申请日：2013-08-01
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide an irreversible Bruton's kinase inhibitor compound to be used in treatment of diseases.SOLUTION: There is provided a compound illustrated in formulae.
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公开(公告)号：WO2011046964A3
公开(公告)日：2011-08-25
申请号：PCT/US2010052377
申请日：2010-10-12
Applicant: PHARMACYCLICS INC , CHEN WEI , LOURY DAVID J , MODY TARAK D , VERNER ERIK , SMYTH MARK STEPHEN , LUO WENCHEN
Inventor： CHEN WEI , LOURY DAVID J , MODY TARAK D , VERNER ERIK , SMYTH MARK STEPHEN , LUO WENCHEN
IPC: C07D487/04 , A61K31/519 , A61P19/02 , A61P19/10 , C07D401/04 , C07D401/14
CPC classification number: C07D487/04 , C07D519/00
Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.
Abstract translation: 本文描述的是激酶抑制剂化合物，用于合成这种抑制剂的方法，以及在治疗疾病中使用这些抑制剂的方法。 本文进一步描述了用于测定包括激酶在内的蛋白质的适当抑制剂的方法，测定和系统。
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公开(公告)号：WO2015048689A8
公开(公告)日：2015-05-07
申请号：PCT/US2014058132
申请日：2014-09-29
Applicant: PHARMACYCLICS INC
Inventor： WANG LONGCHENG , CHEN WEI , JIA ZHAOZHONG J , LOURY DAVID J
IPC: C07D403/14 , A61K31/519 , A61P19/00 , A61P19/02 , C07D401/14
CPC classification number: C07D487/04
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Abstract translation: 本文公开了与布鲁顿酪氨酸激酶（Btk）形成共价键的化合物。 还描述了Btk的不可逆抑制剂。 此外，还描述了Btk的可逆抑制剂。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。
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公开(公告)号：WO2013010136A3
公开(公告)日：2013-07-04
申请号：PCT/US2012046779
申请日：2012-07-13
Applicant: PHARMACYCLICS INC , CHEN WEI , LOURY DAVID J , MODY TARAK D , WANG LONGCHENG
Inventor： CHEN WEI , LOURY DAVID J , MODY TARAK D
IPC: A61K31/52 , A61K31/433 , A61P17/00 , A61P29/00 , C07D473/32 , C07D473/34
CPC classification number: C07D487/04 , A61K31/52 , C07D473/34
Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.
Abstract translation: 本文描述的是激酶抑制剂化合物，合成这种抑制剂的方法，以及在治疗疾病中使用这些抑制剂的方法。 本文进一步描述了用于确定包括激酶在内的蛋白质的适当抑制剂的方法，测定和系统。
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公开(公告)号：WO2008121742A3
公开(公告)日：2008-11-27
申请号：PCT/US2008058528
申请日：2008-03-27
Applicant: PHARMACYCLICS INC , HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
CPC classification number: C07D487/04 , A61K31/52 , C07D471/04 , C12Q1/485 , G01N33/57426 , G01N2440/14 , G01N2500/00
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
Abstract translation: 本文描述的是不可逆激酶抑制剂化合物，用于合成这种不可逆抑制剂的方法，以及使用这种不可逆抑制剂治疗疾病的方法。 本文进一步描述了用于确定包括激酶在内的蛋白质的合适的不可逆抑制剂的方法，测定和系统。
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Patent Agency Ranking6.发明申请INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS 审中-公开用于治疗固体肿瘤的BRUTON的酪氨酸激酶的抑制剂
公开(公告)号：WO2010009342A3
公开(公告)日：2010-05-14
申请号：PCT/US2009050897
申请日：2009-07-16
Applicant: PHARMACYCLICS INC , HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
CPC classification number: A61K31/519 , A61K31/00 , A61K31/337 , A61K31/52 , A61K31/675 , A61K31/704 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2300/00 , A61K31/19
Abstract: Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
Abstract translation: 本文描述的是不可逆的Btk抑制剂化合物，以及使用这种不可逆抑制剂治疗以固体肿瘤的存在或发展为特征的疾病和病症的方法。
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7.发明公开CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 审中-公开ZIMTSÄUREHYDROXYAMIDEAS蛋白去乙酰化酶8的抑制剂
公开(公告)号：EP2797875A4
公开(公告)日：2015-09-02
申请号：EP12863933
申请日：2012-12-19
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , CHEN WEI , BALASUBRAMANIAN SRIRAM
IPC: C07C259/06 , A61K31/165 , A61P43/00 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06 , C07D405/06
CPC classification number: C07D405/06 , C07C235/34 , C07C235/38 , C07C259/06 , C07C311/08 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/36 , C07D213/65 , C07D213/68 , C07D213/82 , C07D213/89 , C07D295/088 , C07D401/06
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公开(公告)号：EP2393816A4
公开(公告)日：2011-12-14
申请号：EP10823966
申请日：2010-10-12
Applicant: PHARMACYCLICS INC
Inventor： CHEN WEI , LOURY DAVID J , MODY TARAK D , VERNER ERIK , SMYTH MARK STEPHEN , LUO WENCHEN
IPC: C07D487/04 , A61K31/519 , A61P19/02 , A61P19/10 , C07D401/04 , C07D401/14
CPC classification number: C07D487/04 , C07D519/00
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9.发明公开INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS 有权BRUTON TYROSINE KINASE HEMMER治疗实体肿瘤
公开(公告)号：EP2307025A4
公开(公告)日：2011-11-30
申请号：EP09798770
申请日：2009-07-16
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/00 , A61K31/519 , A61P35/00
CPC classification number: A61K31/519 , A61K31/00 , A61K31/337 , A61K31/52 , A61K31/675 , A61K31/704 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2300/00 , A61K31/19
Abstract: Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
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公开(公告)号：EP2139487A4
公开(公告)日：2010-04-21
申请号：EP08744513
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , BUGGY JOSEPH J , LOURY DAVID , CHEN WEI
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
CPC classification number: C07D487/04 , A61K31/52 , C07D471/04 , C12Q1/485 , G01N33/57426 , G01N2440/14 , G01N2500/00
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