公开(公告)号：AU2016243553B2

公开(公告)日：2020-10-08

申请号：AU2016243553

申请日：2016-03-28

Applicant: PRESSURE BIOSCIENCES INC

Inventor： TING EDMUND Y

IPC: F04B9/115 ,  A23L3/015 ,  F04B9/10 ,  F04B9/103 ,  F04B9/107 ,  F04B15/00

Abstract: A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.

公开(公告)号：AU2015266700A1

公开(公告)日：2016-12-15

申请号：AU2015266700

申请日：2015-05-29

Applicant: PRESSURE BIOSCIENCES INC

Inventor： GROSS VERA ,  TING EDMUND Y ,  LAZAREV ALEXANDER ,  SCHUMACHER RICHARD T

IPC: C12N1/06 ,  C12M3/08 ,  G01N1/28

Abstract: Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

公开(公告)号：CA2950739A1

公开(公告)日：2015-12-03

申请号：CA2950739

申请日：2015-05-29

Applicant: PRESSURE BIOSCIENCES INC

Inventor： GROSS VERA ,  TING EDMUND Y ,  LAZAREV ALEXANDER ,  SCHUMACHER RICHARD T

IPC: C12N1/06 ,  C12M3/08 ,  G01N1/28

Abstract: Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

公开(公告)号：AU2020360387A1

公开(公告)日：2022-04-21

申请号：AU2020360387

申请日：2020-09-30

Applicant: PRESSURE BIOSCIENCES INC

Inventor： TING EDMUND Y ,  LAZAREV ALEXANDER

IPC: B65D47/06 ,  A47G19/22 ,  A61B1/00

Abstract: A valve includes a valve seat body received by a sleeve with an interference fit between the valve seat body and the sleeve. An upper end of the sleeve extends beyond an upper end of the valve seat body. A valve assembly including the valve is also provided.

公开(公告)号：CA2808412C

公开(公告)日：2021-10-12

申请号：CA2808412

申请日：2011-08-18

Applicant: PRESSURE BIOSCIENCES INC

Inventor： LAZAREV ALEXANDER ,  TING EDMUND Y

IPC: G01N1/28 ,  C12M1/33 ,  C12M1/40

Abstract: Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.

公开(公告)号：AU2016318955A1

公开(公告)日：2018-04-26

申请号：AU2016318955

申请日：2016-09-08

Applicant: PRESSURE BIOSCIENCES INC

Inventor： TING EDMUND Y ,  LAZAREV ALEXANDER ,  MA JUN

IPC: F16K3/24 ,  F16K1/12 ,  F16K1/38 ,  F16K31/62

Abstract: A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.

公开(公告)号：CA2808412A1

公开(公告)日：2012-02-23

申请号：CA2808412

申请日：2011-08-18

Applicant: PRESSURE BIOSCIENCES INC

Inventor： LAZAREV ALEXANDER ,  TING EDMUND Y

IPC: G01N1/28 ,  C12M1/33 ,  C12M1/40

Abstract: Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.

公开(公告)号：CA2678033A1

公开(公告)日：2008-07-31

申请号：CA2678033

申请日：2008-01-25

Applicant: PRESSURE BIOSCIENCES INC

Inventor： TING EDMUND Y

IPC: B01J3/00 ,  B01J3/03 ,  C12M1/00

Abstract: A pressure cycling system includes a reaction chamber configured to recei ve a sample and a charge pump in fluid communication with the reaction chamb er. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed betwe en the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in t he reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pr essurize the reaction chamber to a first pressure through operation of the c harge pump. The controller is also configured to fluctuate the pressure in t he reaction chamber between a second pressure and a third pressure through o peration of the pressure intensifier.

公开(公告)号：EP3149151A4

公开(公告)日：2017-11-01

申请号：EP15798802

申请日：2015-05-29

Applicant: PRESSURE BIOSCIENCES INC

Inventor： GROSS VERA ,  TING EDMUND Y ,  LAZAREV ALEXANDER ,  SCHUMACHER RICHARD T

IPC: C12N1/06 ,  B01L3/00 ,  C12M1/33 ,  C12M3/08 ,  G01N1/28

CPC classification number: B01L3/50853 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/046 ,  G01N1/286

Abstract: Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

公开(公告)号：AU2016243553A1

公开(公告)日：2017-10-26

申请号：AU2016243553

申请日：2016-03-28

Applicant: PRESSURE BIOSCIENCES INC

Inventor： TING EDMUND Y

IPC: F04B9/115 ,  A23L3/015 ,  F04B9/10 ,  F04B9/103 ,  F04B9/107 ,  F04B15/00

Abstract: A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.