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    Pump mechanism for use in a medicament-dispensing system
    12.
    发明公开
    Pump mechanism for use in a medicament-dispensing system 审中-公开
    Pumpenmechanismus zur Verwendung in einem Arzneimittelabgabesystem

    公开(公告)号：EP2106817A1

    公开(公告)日：2009-10-07

    申请号：EP09009018.4

    申请日：2000-12-11

    Applicant: PY, Daniel

    Inventor： PY, Daniel

    IPC: A61M11/06

    CPC classification number: B05B11/3066 ,  A61M11/001 ,  A61M11/06 ,  A61M15/0025 ,  A61M15/0026 ,  A61M15/0065 ,  A61M2205/073 ,  A61M2206/16 ,  B05B1/341 ,  B05B1/3436 ,  B05B11/0037 ,  B05B11/0043 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/0075 ,  B05B11/3001 ,  B05B11/3011 ,  B05B11/3074 ,  B05B11/3076 ,  B05B11/3077 ,  B05B11/309 ,  B05B11/3092 ,  B05B11/3095

    Abstract: A pump mechanism for use in a medicament-dispensing system having a vial for holding a volume of medicament, a deformable body portion for providing a spring action to the pump mechanism, and a nozzle portion through which medicament is emitted. The pump mechanism comprises a pump sleeve positioned within the deformable body portion. The sleeve has a dosage cavity of pre-determined volume for collecting medicament from the vial and is connected to the nozzle portion. The sleeve has a fluid-inlet orifice for channelling medicament into the dosage cavity. A piston is at least partially and slidably positioned in the pump sleeve for emitting medicament from the dosage cavity via the nozzle portion. The piston is operational coupled to the deformable body portion. At least one O-shaped ring is provided on an annular portion of the piston slidably engaging the pump sleeve to provide a fluid-tight seal.

    Abstract translation: 一种用于药物分配系统的泵机构，其具有用于容纳一定体积的药物的小瓶，用于向所述泵机构提供弹簧作用的可变形体部分以及喷射药物的喷嘴部分。 泵机构包括定位在可变形主体部分内的泵套筒。 套筒具有用于从小瓶收集药物并且连接到喷嘴部分的预定体积的剂量空腔。 套筒具有用于将药物引导到剂量腔中的流体入口孔。 活塞至少部分地且可滑动地定位在泵套筒中，用于经由喷嘴部分从剂量空间发射药物。 活塞可操作地联接到可变形体部分。 至少一个O形环设置在活塞的环形部分上，可滑动地与泵套接合以提供流体密封。

    SELF CLOSING AND OPENING FILLING NEEDLE, NEEDLE HOLDER, FILLER AND METHOD
    16.
    发明申请
    SELF CLOSING AND OPENING FILLING NEEDLE, NEEDLE HOLDER, FILLER AND METHOD 审中-公开
    自动关闭和打开填充针，针座，填充器和方法

    公开(公告)号：WO2015175356A1

    公开(公告)日：2015-11-19

    申请号：PCT/US2015/030044

    申请日：2015-05-09

    Applicant: DR, PY INSTITUTE LLC ,  PY, Daniel

    Inventor： PY, Daniel

    IPC: A61M5/32

    CPC classification number: B65B43/54 ,  B65B3/003 ,  B65B3/04 ,  B65B39/001 ,  B65B39/004 ,  B65B39/12 ,  B65B51/02 ,  B65B51/10 ,  B65B55/24

    Abstract: An apparatus for filling a device having a penetrable septum and a sealed chamber. The apparatus includes a filling member engageable with the penetrable septum to penetrate the septum, port(s), and a closure. The closure and filling member are movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). The filling member and/or septum is movable relative to the other between (i) a first position wherein the filling member is spaced from the septum, and (ii) a second position wherein the filling member is penetrated through the septum and in communication with the sealed chamber. A locking device is movable between (i) a locked position locking the closure and/or filling member in the first position, and (ii) an unlocked position allowing movement of the closure and/or filling member relative to the other and into the second position.

    Abstract translation: 一种用于填充具有可穿透隔膜的装置和密封室的装置。 该装置包括可与可穿透的隔膜接合以便穿透隔膜，端口和封闭件的填充构件。 闭合和填充构件可在（i）第一位置和第二位置之间移动，第一位置，其中闭合件关闭端口，和（ii）打开端口的第二位置。 填充构件和/或隔膜可以在（i）第一位置和第二位置之间相对于另一个移动，其中填充构件与隔膜间隔开，以及（ii）第二位置，其中填充构件穿过隔膜并与 密封室。 锁定装置可以在（i）将封闭件和/或填充构件锁定在第一位置的锁定位置之间移动，以及（ii）允许封闭件和/或填充构件相对于另一个移动并进入第二位置的解锁位置 位置。

    MODULAR FILLING APPARATUS AND METHOD
    17.
    发明申请
    MODULAR FILLING APPARATUS AND METHOD 审中-公开
    模块化灌装装置及方法

    公开(公告)号：WO2013155369A1

    公开(公告)日：2013-10-17

    申请号：PCT/US2013/036296

    申请日：2013-04-12

    Applicant: PY, Daniel

    Inventor： PY, Daniel

    IPC: B65B55/02 ,  A61L2/00

    CPC classification number: B65B3/003 ,  B65B7/16 ,  B65B51/02 ,  B65B55/04 ,  B65B55/08 ,  B65B55/10 ,  B65B61/002 ,  B65B2039/009

    Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.

    Abstract translation: 用于无菌填充的装置和方法包括使包括针穿透隔膜的装置的针穿透表面和与针可穿透隔膜流体连通的密封室中的污染。 填充针穿透针穿透隔膜，通过填充针引入物质并进入腔室，然后从隔膜中取出。 将液体密封剂施加到隔膜的穿透区域。 将辐射或能量施加到液体密封剂以将液体密封剂从液相固化至固相。

    DISPENSER WITH PLURAL PRODUCT CHAMBERS FOR SEPARATE STORAGE AND INTERMIXING OF PRODUCTS PRIOR TO USE, AND RELATED METHOD
    18.
    发明申请
    DISPENSER WITH PLURAL PRODUCT CHAMBERS FOR SEPARATE STORAGE AND INTERMIXING OF PRODUCTS PRIOR TO USE, AND RELATED METHOD 审中-公开
    具有广泛产品的分配器，用于单独存储和使用前的产品的介绍以及相关方法

    公开(公告)号：WO2009055833A1

    公开(公告)日：2009-04-30

    申请号：PCT/US2008/081396

    申请日：2008-10-27

    Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

    Inventor： PY, Daniel

    IPC: B67D5/60

    CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

    Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

    Abstract translation: 一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及容器盖，该容器封闭件包括用于在储存期间气密地密封室内的产品的主密封件。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。 容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到 允许产品从腔室通过流出口并进入分配构件以分配产品。

    LIQUID NUTRITION PRODUCT DISPENSER WITH PLURAL PRODUCT CHAMBERS FOR SEPARATE STORAGE AND INTERMIXING PRIOR TO USE, AND RELATED METHOD
    19.
    发明申请
    LIQUID NUTRITION PRODUCT DISPENSER WITH PLURAL PRODUCT CHAMBERS FOR SEPARATE STORAGE AND INTERMIXING PRIOR TO USE, AND RELATED METHOD 审中-公开
    液体营养产品分配器，具有单独存储和使用前的独立存储和相关方法的相关方法

    公开(公告)号：WO2009055832A1

    公开(公告)日：2009-04-30

    申请号：PCT/US2008/081395

    申请日：2008-10-27

    Applicant: MEDICAL INSTILL TECHNOLOGIES INC. ,  NESTEC LTD. ,  PY, Daniel

    Inventor： PY, Daniel

    IPC: B67D5/56

    CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

    Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

    Abstract translation: 一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及容器盖，该容器封闭件包括用于在储存期间气密地密封室内的产品的主密封件。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。 容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到 允许产品从腔室通过流出口并进入分配构件以分配产品。

    APPARATUS AND METHOD FOR FORMULATING AND ASEPTICALLY FILLING LIQUID PRODUCTS
    20.
    发明申请
    APPARATUS AND METHOD FOR FORMULATING AND ASEPTICALLY FILLING LIQUID PRODUCTS 审中-公开
    用于制备和自由填充液体产品的装置和方法

    公开(公告)号：WO2009046386A1

    公开(公告)日：2009-04-09

    申请号：PCT/US2008/078862

    申请日：2008-10-03

    Applicant: PY, Daniel

    Inventor： PY, Daniel

    IPC: A23B5/005 ,  B65B55/00

    CPC classification number: A23L3/04 ,  A23L2/46 ,  A23L3/22 ,  B65B3/04 ,  B65B55/025 ,  B65B55/10 ,  B65B55/12

    Abstract: An apparatus and method are provided for formulating and aseptically filling liquid products. A first liquid source includes at least one first liquid component; a second liquid source includes at least one second liquid component; and a container includes a body defining an empty, sterile storage chamber therein that is sealed with respect to ambient atmosphere. The container is introduced into a sterile filling chamber. A first filling member coupled in fluid communication with the first liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the first liquid component is aseptically introduced through the first filling member and into the storage chamber. A second filling member coupled in fluid communication with the second liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the second liquid component is aseptically introduced through the second filling member and into the storage chamber and, in turn, the first and second liquid components are combined into a liquid product formulation within the sterile chamber of the container. The first and second filling members are withdrawn from fluid communication with the storage chamber of the container located within the sterile filling chamber, and the filled storage chamber is sealed with respect to ambient atmosphere to hermetically seal the liquid product formulation within the storage chamber of the container.

    Abstract translation: 提供了用于配制和无菌灌装液体产品的装置和方法。 第一液体源包括至少一个第一液体组分; 第二液体源包括至少一个第二液体组分; 并且容器包括在其中限定相对于环境大气密封的空的无菌储存室的主体。 将容器引入无菌填充室。 与第一液体源流体连通的第一填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，第一液体组分被无菌地通过第一填充构件引入储存室 。 与第二液体源流体连通的第二填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，并且第二液体组分被无菌地通过第二填充构件引入并进入储存室 而又将第一和第二液体组分组合成容器无菌室内的液体产品制剂。 第一和第二填充构件与位于无菌填充室内的容器的储存室流体连通地取出，并且填充的储存室相对于环境大气密封，以将液体产品配制物气密地密封在储存室内 容器。

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