公开(公告)号：DE102016012235B3

公开(公告)日：2018-02-15

申请号：DE102016012235

申请日：2016-10-10

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: A61B90/16 ,  A61B1/273 ,  A61M25/01

Abstract: Zur Durchführung endoskopischer Untersuchungen des oberen Gastrointestinaltraktes wird ein Beißring benötigt, der in den Mund des Patienten eingeführt wird. Die Seiten des Mittelstückes des Beißringes sind bisher starr und verhindern unter gewissen Umständen das Einführen des Beißringes, wodurch die Untersuchung nicht durchgeführt werden kann, oder es kommt zu Verletzungen des Mund-/Zahnapparates des Patienten mit z. T. erheblichen Folgen. Die Seiten (b) des Mundstückes (a) des Beißringes werden flexibel (ähnlich einer Ziehharmonika) verändert, so dass eine vertikale Höhenverstellung/-verminderung möglich wird. Konsekutiv erfolgt eine entsprechende ziehharmonika ähnliche Veränderung in den Haltebögen (c) des Beißringes. Dies ermöglicht bisher nicht durchführbare Untersuchungen und führt zur Reduktion substantieller Verletzungen im Mund-/Zahnapparat des Patienten mit weiteren möglichen Folgen (z. B. Aspiration abgebrochener Zahnanteile in das Bronchialsystem). Durchführung endoskopischer Untersuchungen des oberen Gastrointestinaltraktes

公开(公告)号：GB191010471A

公开(公告)日：1911-04-27

申请号：GB191010471D

申请日：1910-04-28

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: B28B11/16

Abstract: 10,471. Roth, J. April 28. Stream-cutting machines; punching and perforating machines.-Relates to automatic tile-cutting machines of the type in which the cutting &c. devices are driven from an independently-driven shaft controlled by a shaft operated by the moving clay stream, and consists in the combination with the controlling-shaft of means for actuating the carriage carrying the cutting-devices, means for periodically releasing the cutter-actuating shaft, and means for controlling a stub cutter. The stream of clay 2, Fig. 1, passes over rollers 7 mounted upon shafts 3 fitted with pulleys 4, Fig. 5, around which passes a band 6 adapted to drive an interchangeable pulley 5 mounted upon the controlling shaft 17. A disk 59, Fig. 1, mounted upon the shaft 17 is fitted with a pin 60 which engages with a rod 61 connected to the carriage 9 and moves it forward, and with a cam 62 which engages with a lever 63, also connected to the carriage 9, and returns it. The pin 60 m a y be adjustably arranged on the disk 59. On the end of the shaft 17 is mounted a cam 18, Fig. 11, which deflects a lever 19 against the action of a spring 24 out of the path of a cam 14 and releases a shaft 11 connected to an independently-driven shaft through a friction coupling 12, Fig. 1. A crank 34, Fig. 3, on the shaft 11 rocks a lever by means of a pin 36 and slot 37, and this lever reciprocates a frame 45 which, by gearing 44, 30, oscillates a frame 33 carrying the cutting- wire 58, for the shaped end of the tile. The wire 58 is attached to pieces 33 , 33 , sliding radially on arms 33, 33 and fitted with rollers 57 engaging with a pattern guide 56, Fig. 1. The straight ends of the tiles are cut by a wire 52 , Fig. 4, carried by a frame 52, which is reciprocated by a lever 49 connected to a crank by a rod 46. A roller 66 on the frame 52 raises a lever 67 carrying the stub cutter 67 , which is then retained by a lever 68 mounted on a shaft 71. A cam 69, Fig. 3, on the shaft 17 engages a lever 70 carried by the shaft 71 and rocks the latter to deflect the lever 68 when a sufficient length of the rib 2 has been cut away. The tiles are also stamped and perforated during the movement of the frame 52 by means of devices carried by a frame 74, which is depressed by a roller 72 against the action of a spring 75. Fig. 6 shows a modification in which the stamping and perforating devices and also the stub cutter are actuated by the sliding frame 45 ; the reciprocation of the frame 45 rocks a shaft 82 which, by means of a pin 84 carried by a lever 83 engaging which a slotted member 86, depresses the stamping and perforating devices 90, and through levers 89, 93 and a link 94 elevates the stub cutter 98, which is retained by a member 99 engaging a catch 100 until, on the return of the carriage 9, the catch is deflected by an adjustable stop 101. In a further modification shown in Fig. 9, the whole of the cutting-devices are actuated by the frame 45, the straight end of the tile being cut by a wire 103 carried by a frame 102 mounted on the shaft 82.

公开(公告)号：CH51772A

公开(公告)日：1911-09-16

申请号：CH51772D

申请日：1910-03-19

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

公开(公告)号：AT47612B

公开(公告)日：1911-04-25

申请号：AT47612D

申请日：1910-01-10

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

公开(公告)号：WO2012143124A3

公开(公告)日：2013-04-04

申请号：PCT/EP2012001670

申请日：2012-04-18

Applicant: ROTH & WEBER GMBH ,  ROTH JOHANNES ,  ERMERT GERD

Inventor： ROTH JOHANNES ,  ERMERT GERD

IPC: H04N1/04 ,  H04N1/19 ,  H04N1/193 ,  H04N1/387

CPC classification number: H04N1/10 ,  H04N1/04 ,  H04N1/1903 ,  H04N1/1933 ,  H04N1/387 ,  H04N1/3876 ,  H04N2201/0456

Abstract: The invention relates to a large-format scanning system (1) comprising at least two image acquisition elements (2) in a cascade arrangement, at least one platen, preferably a glass plate (3), arranged upstream thereof, and at least two reflector rolls (5) arranged opposite the at least two image acquisition elements (2) in a cascade arrangement, said reflector rolls being pressed against the glass plate (3) and/or a copy (4) to be scanned by means of resilient elements (6) that are arranged at the sides of the reflector rolls (5). According to the invention, the side portions (7) of the reflector rolls (5) are designed such that they touch the glass plate (3) only outside the reading area of the image acquisition elements (2) for the copy to be scanned (4) and that the copy to be scanned (4) rests on the glass plate (3) in the center area (8) of the reflector rolls (5).

Abstract translation: 本发明涉及一种大幅面扫描仪系统（1）具有至少两个级联的图像感测元件（2），至少一个布置在所述文档支持的前面，优选地布置玻璃（3）的面板中，并用至少两个级联的图像感测元件（2）相反，镜面辊（ 5），其通过的装置，被布置（在所述反射器辊5）的弹性元件被压在玻璃板（3）和/或（4）的扫描模板（6）的侧面上。 根据本发明，在它们的侧部区域（7）的反射器辊子（5）被设计成使得它们只触摸图像感测元件（2），用于在扫描模板的读取范围外（4）的玻璃板（3），并且所述扫描模板（4） 在中心区域（8）的反射器辊（5）与玻璃板（3）。

公开(公告)号：WO2011117392A2

公开(公告)日：2011-09-29

申请号：PCT/EP2011054630

申请日：2011-03-25

Applicant: UNIVERSITAETSKLINIKUM MUENSTER ,  EHRCHEN JAN ,  VARGA GEORG ,  ROTH JOHANNES ,  SUNDERKOETTER CORD

Inventor： EHRCHEN JAN ,  VARGA GEORG ,  ROTH JOHANNES ,  SUNDERKOETTER CORD

IPC: G01N33/50

CPC classification number: A61K35/15 ,  A61K45/06 ,  A61K2035/122 ,  A61K2035/124 ,  C12N5/0645 ,  C12N2501/22 ,  C12N2501/39 ,  G01N33/5047

Abstract: The present invention relates to a pharmaceutical composition comprising glucocorticoid (GC)-induced human monocytes, and optionally a pharmaceutically acceptable carrier. The present invention further relates to a pharmaceutical composition comprising GC and optionally a pharmaceutically acceptable carrier, for use in the treatment of a disease which is GC-responsive, wherein said pharmaceutical composition is to be administered to human monocytes ex vivo. The pharmaceutical composition may be used for treatment of a disease which is GC-responsive. In another aspect, the present invention relates to the use of GC for the preparation of a pharmaceutical composition for the treatment of a patient in need of a GC-therapy, wherein said GC is to be administered to monocytes of said patient ex vivo. In a further embodiment, the present invention relates to a method for the preparation of a pharmaceutical composition comprising the step of contacting human monocytes ex vivo with a GC. A teflon container (e.g. a teflon bag) comprising a glucocorticoid and optionally a colony-stimulating factor (CSF) is also envisaged. In an even further embodiment, the present invention relates to a method of screening for a compound which is suitable for the treatment of a GC-responsive disease, said method comprising: a) contacting a monocyte with a compound to be tested; b) evaluating whether the monocyte is GC-induced; and thereby, c) identifying compounds which are suitable for the treatment of a GC-responsive disease.

Abstract translation: 本发明涉及包含糖皮质激素（GC）诱导的人单核细胞和任选的药学上可接受的载体的药物组合物。 本发明还涉及包含GC和任选的药学上可接受的载体的药物组合物，其用于治疗GC反应性疾病，其中所述药物组合物将离体施用于人单核细胞。 药物组合物可用于治疗GC反应性疾病。 另一方面，本发明涉及GC用于制备用于治疗需要GC治疗的患者的药物组合物的用途，其中所述GC将离体施用于所述患者的单核细胞。 在另一个实施方案中，本发明涉及制备药物组合物的方法，其包括使人单核细胞离体与GC接触的步骤。 还设想了包含糖皮质激素和任选的集落刺激因子（CSF）的特氟隆容器（例如聚四氟乙烯袋）。 在另一个实施方案中，本发明涉及一种筛选适合于治疗GC-应答疾病的化合物的方法，所述方法包括：a）使单核细胞与待测化合物接触; b）评估单核细胞是否是GC诱导的; 因此，c）鉴定适合于治疗GC-应答性疾病的化合物。

公开(公告)号：DE10056072A1

公开(公告)日：2002-05-29

申请号：DE10056072

申请日：2000-11-08

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: A61B5/00 ,  A61B5/0205 ,  G06F19/00 ,  G08B21/04 ,  G08B21/02 ,  G08C17/02

Abstract: The device has an electrical energy storage device for mobile use, an interface to at least one physiological data sensor, an electronic computer unit, an electronic memory for storing a control program and physiological data, a geographic position determination arrangement and an arrangement for wireless transmission of at least some data under the control of the control program taking into account physiological data and stored boundary values. The device has an electrical energy storage device (3) for mobile portable operation, an interface to at least one physiological data sensor (7), an electronic computer unit (6), an electronic memory (8) for storing a control program and physiological data, a geographic position determination arrangement (9) and an arrangement (4) for wireless transmission of at least some data, e.g. as an emergency call, under the control of the control program taking into account the physiological data and stored boundary values. Independent claims are also included for the following: a method of recording and forwarding physiological data.