公开(公告)号：WO2009137129A2

公开(公告)日：2009-11-12

申请号：PCT/US2009033943

申请日：2009-02-12

Applicant: STC UNM ,  RUBIN ROBERT ,  SITDIKOV RAVIL ,  ATANASSOV PLAMEN ,  LOPEZ GABRIEL ,  KONSTANTINOV KONSTANTIN

Inventor： RUBIN ROBERT ,  SITDIKOV RAVIL ,  ATANASSOV PLAMEN ,  LOPEZ GABRIEL ,  KONSTANTINOV KONSTANTIN

CPC classification number: G01N33/564 ,  G01N33/5438 ,  G01N2800/104

Abstract: A rapid electrochemical flow-through sensor and method for detecting the presence of autoantibodies in a fluid sample such as blood is shown and described. The sensor may take either a single- or multi-plexed form. The sensor comprises a fluid inlet, a reaction region comprising immobilized autoantigens and an electrode assembly, and a fluid outlet.

Abstract translation: 显示和描述了用于检测流体样品如血液中自身抗体的存在的快速电化学流通传感器和方法。 传感器可以采用单层或多层复合形式。 传感器包括流体入口，包含固定的自身抗原的反应区域和电极组件以及流体出口。

公开(公告)号：WO2008154412A2

公开(公告)日：2008-12-18

申请号：PCT/US2008066168

申请日：2008-06-06

Applicant: STC UNM ,  GUPTA GAUTAM ,  LOPEZ GABRIEL ,  ATANASSOV PLAMEN

Inventor： GUPTA GAUTAM ,  LOPEZ GABRIEL ,  ATANASSOV PLAMEN

IPC: C08J3/075 ,  C07H1/00 ,  C08G77/60

CPC classification number: A61K9/06 ,  A61K9/127 ,  Y10T428/265 ,  Y10T436/25

Abstract: The disclosure provides a simple and effective way of synthesizing robust organic- inorganic hybrid gels and ultra-thin films using vaporization of a gel precursor. The gels are synthesized at relatively low temperature allowing the activity of the immobilized species to be maintained. The disclosure provides robust, synthetic, selective, active and/or passive transport systems in the form of functional biologically active species and mechanisms for forming them. These systems allow selective and passive or active transport of ionic, molecular and biological species through the incorporation of functional biological molecules and biomolecular assemblies in a rigid matrix.

Abstract translation: 本公开提供了使用凝胶前体的蒸发来合成鲁棒的有机 - 无机杂化凝胶和超薄膜的简单而有效的方法。 凝胶在相对较低的温度下合成，允许保持固定化物质的活性。 本公开提供了功能性生物活性物质形式的强大的，合成的，选择性的，主动的和/或被动的运输系统和用于形成它们的机制。 这些系统通过将功能性生物分子和生物分子组装结合到刚性基质中来允许离子，分子和生物物质的选择性和被动或主动传递。