公开(公告)号：AU2019401254B2

公开(公告)日：2025-05-01

申请号：AU2019401254

申请日：2019-11-19

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： ZHENG GUOZHU ,  BAMBERGER MARK J ,  SMUKSTE INESE

IPC: C07K5/10 ,  A61K38/00 ,  A61P9/10 ,  C07K5/11

Abstract: Disclosed are analogs of elamipretide (MTP-131). The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.

公开(公告)号：LT3723783T

公开(公告)日：2023-03-27

申请号：LTUS2018065755

申请日：2018-12-14

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： ZHENG GUOZHU ,  BAMBERGER MARK ,  SMUKSTE INESE

IPC: A61K38/07 ,  A61P9/10 ,  C07K5/09

公开(公告)号：DK3723783T3

公开(公告)日：2023-03-20

申请号：DK18888579

申请日：2018-12-14

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： ZHENG GUOZHU ,  BAMBERGER MARK J ,  SMUKSTE INESE

IPC: A61K38/07 ,  A61P9/10 ,  C07K5/09

公开(公告)号：AU2021246142A1

公开(公告)日：2022-10-20

申请号：AU2021246142

申请日：2021-04-02

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： KEEFE DENNIS ,  ZHENG GUOZHU

IPC: C07D319/18 ,  A61K31/122 ,  A61P9/00 ,  A61P27/02 ,  C07C39/08 ,  C07C43/23 ,  C07C50/06 ,  C07C50/24 ,  C07D317/46

Abstract: The disclosure provides therapeutic compounds, compositions (e.g., therapeutic agents or medicaments) and methods for preventing or treating mitochondrial disease such as Friedreich's ataxia in a mammalian subject, reducing risk factors, signs and/or symptoms associated with mitochondrial disease, such as Friedreich's ataxia, and/or reducing the likelihood or severity of mitochondrial disease such as Friedreich's ataxia. The disclosure further provides novel intermediates for the production of said therapeutic compositions. In some instances, the intermediates may themselves by therapeutic agents or prodrugs of therapeutic agents (e.g. reduced forms of the therapeutic compounds).

公开(公告)号：AU2020316449A1

公开(公告)日：2022-02-10

申请号：AU2020316449

申请日：2020-07-23

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： BROCCOLI VANIA ,  KEEFE DENNIS ,  ZHENG GUOZHU

IPC: A61K31/4245 ,  A61K45/06 ,  A61P25/16 ,  A61P25/28

Abstract: The present disclosure provides novel methods for treating or preventing amyotrophic lateral sclerosis (ALS), methods for delaying the onset of neurological symptoms associated with ALS, increasing survival in subjects afflicted with ALS, and attenuating the decline of muscle strength associated with ALS in a subject in need thereof. The present disclosure also provides methods for treating or preventing α-synucleinopathy or TDP-43 proteinopathy. The methods comprise administering to the subject an effective amount of a mitochondria-targeting peptidomimetic compound, such as (R)-2-amino-N-((S)-1-(((S)-5-amino-1-(3-benzyl-1,2,4-oxadiazol-5-yl)pentyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropan-2-yl)-5-guanidinopentanamide, or a pharmaceutically acceptable salt, stereoisomer, tautomer, hydrate, and/or solvate thereof.

公开(公告)号：PL3723783T3

公开(公告)日：2023-06-26

申请号：PL18888579

申请日：2018-12-14

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： ZHENG GUOZHU ,  BAMBERGER MARK J ,  SMUKSTE INESE

IPC: A61K38/07 ,  A61P9/10 ,  C07K5/09

公开(公告)号：ES2942631T3

公开(公告)日：2023-06-05

申请号：ES18888579

申请日：2018-12-14

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： ZHENG GUOZHU ,  BAMBERGER MARK ,  SMUKSTE INESE

IPC: A61K38/07 ,  A61P9/10 ,  C07K5/09

Abstract: Se describen péptidos no naturales útiles para el tratamiento y la prevención de lesión por isquemia-reperfusión (p. ej., lesión por isquemia-reperfusión cardiaca) o infarto de miocardio. (Traducción automática con Google Translate, sin valor legal)

公开(公告)号：FI3723783T3

公开(公告)日：2023-03-24

申请号：FI18888579

申请日：2018-12-14

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： ZHENG GUOZHU ,  BAMBERGER MARK ,  SMUKSTE INESE

Abstract: Disclosed are non-natural peptides useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.

公开(公告)号：CA3148090A1

公开(公告)日：2021-01-28

申请号：CA3148090

申请日：2020-07-23

Applicant: STEALTH BIOTHERAPEUTICS INC

Inventor： KEEFE DENNIS ,  ZHENG GUOZHU ,  BROCCOLI VANIA

IPC: A61K38/05 ,  A61P25/16 ,  A61P25/28

Abstract: The present disclosure provides novel methods for treating or preventing amyotrophic lateral sclerosis (ALS), methods for delaying the onset of neurological symptoms associated with ALS, increasing survival in subjects afflicted with ALS, and attenuating the decline of muscle strength associated with ALS in a subject in need thereof. The present disclosure also provides methods for treating or preventing a-synucleinopathy or TDP-43 proteinopathy. The methods comprise administering to the subject an effective amount of a mitochondria-targeting peptidomimetic compound, such as (R)-2-amino-N-((S)-1-(((S)-5-amino-1-(3-benzyl-1,2,4-oxadiazol-5-yl)pentyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropan-2-yl)-5-guanidinopentanamide, or a pharmaceutically acceptable salt, stereoisomer, tautomer, hydrate, and/or solvate thereof.