公开(公告)号：WO0196018A3

公开(公告)日：2002-08-29

申请号：PCT/US0113965

申请日：2001-04-30

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MANSKY PAUL ,  TIEDE RICHARD ,  HAVADTOY STEVE

IPC: B01J19/00 ,  B01L3/00 ,  G01N33/36 ,  G01N35/02

CPC classification number: B01L3/5023 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00484 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01L3/50255 ,  B01L2400/0481 ,  B01L2400/049 ,  G01N33/36 ,  G01N33/367 ,  G01N35/028

Abstract: An apparatus for use in testing a plurality of compositions in parallel. The apparatus includes an upper plate having a plurality of openings extending therethrough to form upper fluid chambers and a lower plate having a plurality of openings extending at least partially therethrough to form cavities. A central plate having a plurality of openings extending therethrough to form central fluid chambers is positioned between the upper and lower plates with the central chambers in alignment with the upper chambers and the cavities. A porous sheet is interposed between the upper and central plates such that an upper surface of the sheet is in contact with fluid within the upper chamber and a lower surface of the sheet is in contact with fluid within the central chamber. The apparatus further includes a flexible membrane positioned between the lower and central plates such that changes in pressure within the cavities or fluid chambers cause deflection of the membrane to force fluid to pass through the porous sheet.

Abstract translation: 用于并行测试多种组合物的装置。 该装置包括具有延伸穿过其中以形成上流体室的多个开口的上板，以及具有至少部分地穿过其延伸以形成空腔的多个开口的下板。 具有贯穿其中以形成中心流体室的多个开口的中心板位于上板和下板之间，中心室与上室和空腔对准。 多孔片介于上板和中板之间，使得片的上表面与上室内的流体接触，并且片的下表面与中心室内的流体接触。 该装置还包括位于下板和中心板之间的柔性膜，使得空腔或流体室内的压力变化导致膜的偏转以迫使流体通过多孔板。

公开(公告)号：WO0193998A3

公开(公告)日：2003-01-16

申请号：PCT/US0117921

申请日：2001-06-01

Applicant: SYMYX TECHNOLOGIES INC

Inventor： NIELSEN RALPH B ,  SAFIR ADAM ,  TIEDE RICHARD ,  MCWAID THOMAS HARDING ,  VANERDEN LYNN

IPC: B01F7/00 ,  B01F7/16 ,  B01F15/00 ,  B01J19/00 ,  C40B40/14 ,  C40B60/14

CPC classification number: B01F15/00207 ,  B01F7/00258 ,  B01F7/00266 ,  B01F7/00291 ,  B01F7/00416 ,  B01F7/00575 ,  B01F7/167 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00342 ,  B01J2219/00353 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14

Abstract: Parallel semi-continuous or continuous reactors are disclosed. The parallel reactors preferably comprise four or more reaction vessels. The reaction vessels are preferably small volume reaction vessels, preferably pressure reaction vessels, and/or preferably integral with a common reactor block. The reaction vessels can comprise shaft-driven stirrers. At least two, preferably at least three or at least four liquid feed lines can provide selective fluid communication between each of the reaction vessels and one or more liquid reagent sources. Additional features, suitable in connection with parallel reactors or with single reaction vessels are also disclosed.

Abstract translation: 公开了平行半连续或连续反应器。 并联反应器优选包含四个或更多个反应容器。 反应容器优选为体积小的反应容器，优选为压力反应容器，和/或优选与普通反应器组合成一体。 反应容器可以包括轴驱动的搅拌器。 至少两个，优选至少三个或至少四个液体进料管线可以在每个反应容器和一个或多个液体试剂源之间提供选择性流体连通。 还公开了适用于并联反应器或单个反应容器的附加特征。

公开(公告)号：WO0032308A3

公开(公告)日：2000-11-23

申请号：PCT/US9928741

申请日：1999-12-03

Applicant: SYMYX TECHNOLOGIES INC ,  FREITAG J CHRISTOPHER ,  HAJDUK DAMIAN ,  NIELSEN RALPH B ,  SAFIR ADAM ,  TIEDE RICHARD

Inventor： FREITAG J CHRISTOPHER ,  HAJDUK DAMIAN ,  NIELSEN RALPH B ,  SAFIR ADAM ,  TIEDE RICHARD

IPC: G01N35/02 ,  B01J4/00 ,  B01J19/00 ,  B01J19/26 ,  C08F2/00 ,  C40B40/14 ,  C40B60/14 ,  G01N35/10

CPC classification number: B01J19/0046 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  Y10S526/92 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A method and apparatus (10) for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel (102), the reactor vessels (102) combined into a reactor block (100). Reactant(s) to be added during the reaction are kept in a header barrel (202), which has a plunger (402) to feed reactant(s) from the header barrel (202) through a transfer line (302) into the reactor vessel (102). The plunger (402) is moved using a drive system (500). The header barrels (202) are optionally combined in a header block (200). The header block (200) is sealed to a plate (300) containing the transfer lines (302), which in turn is sealed to the reactor block (100). A latch mechanism (600) is provided for easy sealing of the reactor (100) and header blocks (200) to the plate (300). The entire apparatus (10) may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.

Abstract translation: 提供了用于以半间歇或连续模式并行地反应多种不同混合物的方法和装置（10）。 每个反应包含在反应器容器（102）内，反应器容器（102）组合成反应器块（100）。 在反应过程中加入的反应物保持在具有活塞（402）的集管桶（202）中以将来自集管桶（202）的反应物通过输送管线（302）供入反应器 容器（102）。 柱塞（402）使用驱动系统（500）移动。 标题桶（202）可选地组合在标题块（200）中。 集管块（200）被密封到包含传输管线（302）的板（300），所述传输管线又被密封到反应器块（100）。 提供闩锁机构（600）以便容易地将反应器（100）和集管块（200）密封到板（300）。 随着反应的进行，整个装置（10）可以放置在摇摆器或旋转盘上用于混合。