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11.发明公开公开(公告)号：US20240020841A1
公开(公告)日：2024-01-18
申请号：US18351084
申请日：2023-07-12
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar , Gianni Pedrizzetti
CPC classification number: G06T7/0014 , G06T7/246 , G06T5/50 , A61B8/481 , A61B8/06 , A61B8/483 , A61B8/0883 , G16H30/40 , G06T2200/04 , G06T2207/20212 , G06T2207/30048 , G06T2207/30104 , G06T2207/10132
Abstract: Systems and methods for producing velocity data associated with three-dimensional (3D) flow field images. In some embodiments, the method includes receiving data associated with a plurality of frames of a flow field relating to image data acquired by a medical imaging device, in which the data includes information corresponding to measurements of the flow field over time within a chamber; performing, for each of the plurality of frames, the following operations including: generating, for a respective frame, a data correction based on an interaction of the flow field with the chamber, applying the data correction to a velocity field corresponding to the respective frame, and imposing an incompressibility constraint for the flow field on one or more data points of the respective frame; and generating, subsequent to imposing the incompressibility constraint, a plurality of corrected velocity fields each of which corresponds to one of the plurality of frames.
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公开(公告)号：US11376417B2
公开(公告)日：2022-07-05
申请号：US16434046
申请日：2019-06-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar
IPC: A61M60/50 , A61N1/362 , A61N1/37 , A61M60/268 , A61M60/871 , A61M60/148 , A61B5/021 , A61B5/318 , A61M60/274
Abstract: A cardiac assist device including a sleeve configured to externally wrap around a native, intact heart; a motor, and a drive shaft that connects the motor to the sleeve, wherein, actuation of the motor and the drive shaft provides a synchronized assisting force to a pumping force of the native, intact whole heart, thereby helping contraction and expansion of the heart located within an internal volume defined by the sleeve. Some embodiments relate to a system for synchronizing the cardiac assist device with a heart including the cardiac assist device; a power supply connected to the motor; and an electrical connector-relay configured to receive electrical signals from the pacemaker and to generate actuating signals that are relayed to the motor and the drive shaft, wherein, during operation of the system in a subject, the heart is assisted in contracting synchronously with the pacemaker signal rhythm.
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13.发明授权公开(公告)号：US11364118B2
公开(公告)日：2022-06-21
申请号：US16031916
申请日：2018-07-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar
Abstract: Some embodiments relate to Some embodiments relate to an integrated ultrasound guided delivery system for positioning or repositioning of a transcatheter heart valve including: a delivery catheter coupled to the transcatheter heart valve, and an intravascular ultrasound (IVUS) catheter operably coupled to the delivery catheter, wherein the IVUS catheter includes an ultrasound transducer tip that is aligned with a base of leaflets of the transcatheter heart valve. Also disclosed is a method for positioning or repositioning a transcatheter heart valve at a target site in a subject including: providing an integrated ultrasound guided delivery system as disclosed herein; advancing the transcatheter heart valve in the vicinity of a native valve, viewing the native valve and the target site in real-time with the IVUS catheter, and deploying the transcatheter heart valve at the target site aiming to maintain a conformal placement within the native valve annulus, thereby avoiding or minimizing paravalvular leak.
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公开(公告)号：US11328416B2
公开(公告)日：2022-05-10
申请号：US16746135
申请日：2020-01-17
Applicant: The Regents of the University of California
Inventor： Ramin Zareian , Arash Kheradvar
Abstract: A method of identifying and quantifying calcified regions of a tissue including obtaining an image of a cross-section of the tissue, wherein the image distinguishes between calcified regions and non-calcified regions of the cross-section of the tissue. Also disclosed are methods of detecting a change in size of a calcified region of a tissue over time including identifying and quantifying a first size of the calcified region of the tissue at a first time, identifying and quantifying a second size of the corresponding calcified region of the tissue at a second time, and detecting a change in size between the first and second size of the calcified region of the tissue in the image of a cross-section of the tissue. Some aspects relate to computer software program configured to construct a panoramic image from partial images, quantify RGB values for each pixel in the panoramic image, and calculate the total pixels of calcified and uncalcified regions and a calcification ratio.
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15.发明授权公开(公告)号：US11182896B2
公开(公告)日：2021-11-23
申请号：US16711129
申请日：2019-12-11
Applicant: The Regents of the University of California
Inventor： Michael Rashidi Avendi , Hamid Jafarkhani , Arash Kheradvar
Abstract: A method of detecting whether or not a body chamber has an abnormal structure or function including: (a) providing a stack of images as input to a system comprising one or more hardware processors configured to obtain a stack of medical images comprising at least a representation of the body chamber inside the patient; to obtain a region of interest using a convolutional network trained to locate the body chamber, wherein the region of interest corresponds to the body chamber from each of the medical images; and to infer a shape of the body chamber using a stacked auto-encoder (AE) network trained to delineate the body chamber, wherein the AE network segments the body chamber; (b) operating the system to detect the body chamber in the images using deep convolutional networks trained to locate the body chamber, to infer a shape of the body chamber using a stacked auto-encoder trained to delineate the body chamber, and to incorporate the inferred shape into a deformable model for segmentation; and (c) detecting whether or not the body chamber has an abnormal structure, wherein an abnormal structure is indicated by a body chamber clinical indicia that is different from a corresponding known standard clinical indicia for the body chamber.
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Patent Agency Ranking
公开(公告)号：US20210261921A9
公开(公告)日：2021-08-26
申请号：US16794115
申请日：2020-02-18
Applicant: The Regents of The University of California
Inventor： Arash Kheradvar , Paria Ali Pour
Abstract: A method of altering energy metabolism in a recipient cell including: identifying the recipient cell as being in need of altering its oxidative phosphorylation status, obtaining exogenous mitochondria, and introducing into the recipient cell the exogenously obtained mitochondria, wherein the exogenously obtained mitochondria functions in the recipient cell to increase or decrease oxidative phosphorylation and/or glycolysis. Also disclosed are isolated cells that include an exogenous mitochondria, wherein the cell demonstrates increased energy metabolism compared to a control cell of the same type but wherein the control cell lacks exogenously added mitochondria. Also disclosed are methods of treating a subject suffering from ischemia or a mitochondrial dysfunction including administering one or more group of isolated cells including exogenous mitochondria as disclosed herein to the subject, wherein the one or more isolated cell including exogenous mitochondria improve symptoms of the ischemia or the mitochondrial dysfunction.
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公开(公告)号：US20210128000A1
公开(公告)日：2021-05-06
申请号：US17089333
申请日：2020-11-04
Applicant: The Regents of the University of California
Inventor： Arash Kheradvar , Farshad Raissi Shabari
Abstract: A network of electrodes configured to sense and/or pace the heart, wherein the network of electrodes are in contact with an epicardial surface of the heart, within a wrapping sleeve that assist the heart as a whole, wherein the network of electrodes sense the heart by quantifying intrinsic electrical activities of the heart, and wherein the network of electrodes pace the heart by inducing an electrical impulse to the heart to control its contractile activities. The network may be interfaced with a controller system, wherein the controller uses spatial and temporal electrical activities of the heart muscles to generate electrical impulse to synchronize the wrapping sleeve around the heart with the heart. Also disclosed is a system configured to construct space-time mapping of cardiac electrical activities and/or propagation, and sensing effects of a first assist event of a prior beat and controlling a second assist event.
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公开(公告)号：US20200234440A1
公开(公告)日：2020-07-23
申请号：US16746135
申请日：2020-01-17
Applicant: The Regents of the University of California
Inventor： Ramin Zareian , Arash Kheradvar
Abstract: A method of identifying and quantifying calcified regions of a tissue including obtaining an image of a cross-section of the tissue, wherein the image distinguishes between calcified regions and non-calcified regions of the cross-section of the tissue. Also disclosed are methods of detecting a change in size of a calcified region of a tissue over time including identifying and quantifying a first size of the calcified region of the tissue at a first time, identifying and quantifying a second size of the corresponding calcified region of the tissue at a second time, and detecting a change in size between the first and second size of the calcified region of the tissue in the image of a cross-section of the tissue. Some aspects relate to computer software program configured to construct a panoramic image from partial images, quantify RGB values for each pixel in the panoramic image, and calculate the total pixels of calcified and uncalcified regions and a calcification ratio.
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公开(公告)号：US20160140730A1
公开(公告)日：2016-05-19
申请号：US14941294
申请日：2015-11-13
Applicant: The Regents of the University of California
Inventor： Ahmad Falahatpisheh , Arash Kheradvar
CPC classification number: A61B8/483 , A61B8/06 , A61B8/0883 , A61B8/485 , A61B8/5223 , G01S13/50 , G01S13/89 , G01S15/588 , G01S15/89 , G01S15/8984 , G01S15/8993 , G06K9/00134 , G06K9/0014 , G06K9/00147 , G06K9/4604 , G06K9/4661 , G06K9/52 , G06K2209/05 , G06T7/215 , G06T7/269 , G06T2200/04 , G06T2207/10136 , G06T2207/30048 , G06T2207/30104
Abstract: The disclosure relates to method of processing three-dimensional images or volumetric datasets to determine a configuration of a medium or a rate of a change of the medium, wherein the method includes tracking changes of a field related to the medium to obtain a deformation or velocity field in three dimensions. In some cases, the field is a brightness field inherent to the medium or its motion. In other embodiments, the brightness field is from a tracking agent that includes floating particles detectable in the medium during flow of the medium.
Abstract translation: 本公开涉及处理三维图像或体积数据集以确定介质的配置或介质变化率的方法，其中该方法包括跟踪与介质相关的场的变化以获得变形或速度 三维领域。 在某些情况下，该场是介质或其运动固有的亮度场。 在其他实施例中，亮度场来自跟踪剂，其包括在介质流动期间在介质中可检测的浮动颗粒。
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公开(公告)号：US20160129469A1
公开(公告)日：2016-05-12
申请号：US14937075
申请日：2015-11-10
Applicant: The Regents of the University of California
Inventor： Lawrence Kulinsky , Arash Kheradvar
CPC classification number: B05D1/02 , A61L27/24 , A61L27/3633 , A61L27/38 , A61L27/54 , A61L2300/414 , B05D1/26 , B05D1/28 , B05D3/067 , C08G61/02 , C08G2261/146 , C08G2261/3424 , C09D165/04
Abstract: Disclosed is an imprinter device comprising an array of adjacent applicators that are arranged so that longitudinal axes of each of the adjacent applicators are parallel to each other, wherein the applicators are configured to make contact with and conform to a surface of a three dimensional (3D) object. In some embodiments, the applicators move independently of each other with respect to the surface of the object, and wherein the applicators are configured to apply a material over the object while in proximity to the surface of the object. Also disclosed are methods of conformal coating a surface of an object.
Abstract translation: 公开了一种打印装置，其包括相邻施加器的阵列，其布置成使得每个相邻施加器的纵向轴线彼此平行，其中施加器被构造成与三维（3D）的表面接触并且符合 ）对象。 在一些实施例中，施加器相对于物体的表面彼此独立地移动，并且其中施加器被构造成在材料的表面附近施加材料在物体上方。 还公开了保形涂覆物体表面的方法。
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