公开(公告)号：JPS5855487A

公开(公告)日：1983-04-01

申请号：JP15302681

申请日：1981-09-29

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  FUJIMURA SUSUMU

IPC: C07D487/04

Abstract: NEW MATERIAL:The compound of formulaI[R is 1-4C alkyl or halogen; m is 0-3; R is 1-4C alkyl or group of formula II (R is 1-4C alkyl, 1-4C alkoxy or halogen; n is 0-3)]. EXAMPLE:2, 3, 6, 7-Tetrahydro-2, 5, 7-trioxo-3, 4, 6-triphenyl-5H-pyrrolo[3,4-d]- pyrimidine. USE:Useful as pesticides, pharmaceuticals, and their synthetic intermediates. PROCESS:The compound of formulaIcan be prepared by reacting the aminomaleimide of formula III with phosgene or trichloromethyl chloroformate in the presence of pyridine, and reacting the resultant compound with the amine of formula R -NH2.

公开(公告)号：JPS5855456A

公开(公告)日：1983-04-01

申请号：JP15302781

申请日：1981-09-29

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  FUJIMURA SUSUMU

IPC: A01N47/18 ,  C07D207/456

Abstract: NEW MATERIAL:The alkoxycarbonylaminomaleimide of formulaI(R is 1-4C alkyl or halogen; n is 0-3; R is benzoyl or ethoxycarbonyl; R is 1-4C alkyl). EXAMPLE:3-Benzoyl-4-(ethoxycarbonyl)amino-1-phenylmaleimide. USE:Useful as pharmaceuticals, pesticides or their intermediates. PROCESS:The compound of formulaIcan be prepared by reacting the aminomaleimide of formula II with phosgene or trichloromethyl chloroformate in a solvent such as benzene, methylene chloride, etc. in the presence of pyridine, especially at -20-+30 deg.C, and reacting the resultant product with the alcohol of formula III usually at 0-100 deg.C.

公开(公告)号：JPS5687541A

公开(公告)日：1981-07-16

申请号：JP16360379

申请日：1979-12-18

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  JIBIKI HIROSHI ,  KAKEYA NOBORU ,  FUJIMURA SUSUMU ,  OKIMOTO KIYOMI

IPC: C07B61/00

Abstract: PURPOSE:To obtain the titled compound useful as an intermediate of pharmaceuticals and agricultural chemicals in high yield, by the reaction of a cyanoformate and an active methylene compound in the presence of the reaction product of stannous chloride and an N-halo compound, followed by treatment with water, etc. CONSTITUTION:A compound of formula I (R is 1-4C alkyl) and an active methylene compound of formula II [R is CN, COR (R is 1-4C alkyl or 6-14C aryl), etc.; R is H, CN, COR , etc.] are made to react in the presence of the reaction product of stannous chloride and an N-halo compound selected from the group of N-halobenzenesulfonamide, N-halo-epsilon-caprolactam and N-halosuccinimide. The product obtained is treated with water or an acidic aqueous solution (e.g. hydrochloric acid, sulfuric acid, etc.) at 0-35 deg.C to give a compound of formula III (e.g. 1-amino-2-cyano-1,2-dimethoxycarbonylethylene).

公开(公告)号：JPS60218365A

公开(公告)日：1985-11-01

申请号：JP7290784

申请日：1984-04-13

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU

IPC: C07C257/14 ,  C07C67/00 ,  C07C239/00

Abstract: NEW MATERIAL:A compound of formula I (R is 1-6C alkyl; R is 1-6C alkyl or benzyl; R and R may mutually link or through O form a ring when R is alkyl). EXAMPLE:N,N-Oxydiethyleneamidinecarboxamide. USE:Useful as an agricultural chemical, medicine and intermediate therefor. PREPARATION:An alkoxyiminoacetamide of formula II (R is lower alkyl) is reacted with a secondary amine of formula III in the presence of a solvent, e.g. benzene, at 20-100 deg.C for 1-100hr to give the aimed compound of formula I .

公开(公告)号：JPS5865273A

公开(公告)日：1983-04-18

申请号：JP16098581

申请日：1981-10-12

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  FUJIMURA SUSUMU

IPC: A01N47/36 ,  A01N37/32 ,  C07D207/456

Abstract: NEW MATERIAL:The compound of formulaI[R is 1-4C alkyl or halogen; m is 0-3; R is 2-5C alkoxycarbonyl or benzoyl; X is amino, -NHR (R is 1-4C alkyl, 2-4C alkenyl, 5-7C cycloalkyl, 7-10C aralkyl, etc.), or -N(CH2)p (p is 4-6)]. EXAMPLE:3-Ethoxycarbonyl-1-phenyl-4-(phenylcarbamoyl)aminomaleimide. USE:Pharmaceuticals, pesticides and their intermediate. PROCESS:The compound of formulaIcan be prepared by reacting the amino- maleimide of formula II with phosgene or trichloromethyl chloroformate preferably in an organic solvent in the presence of pyridine at -20-+30 deg.C for 0.5- 5hr, and reacting the resultant compound with the amine of formula X-H at -20-+100 deg.C for 1-20hrs.

公开(公告)号：JPS5859983A

公开(公告)日：1983-04-09

申请号：JP15807481

申请日：1981-10-06

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  FUJIMURA SUSUMU ,  OKIMOTO KIYOMI ,  JIBIKI HIROSHI

IPC: C07D487/04 ,  A01N43/90

Abstract: NEW MATERIAL:A compound of formulaI{R is 1-4C alkyl, 2-4C alkenyl, 5-7C cycloalkyl, 7-10C aralkyl or group of formula II[R is 1-4C alkyl or halogen; (n) is an integer 0, 1, 2 or 3] . EXAMPLE:3, 6-Dimethyl -2- hydroxy -3, 4, 6, 7-tetrahydro-4, 5, 7-trioxo-5H-pyrrolo [3 4-d]pyrimidine. USE:Useful as medicines, agricultural chemicals or synthetic intermediates therefor. PROCESS:An aminomaleimide of formula III, e.g. 3-amino-1-methyl-4-(methylcarbamoyl) maleimide, is reacted with phosgene or trichloromethyl chloroformate in the presence of pyridine in a solvent, e.g. benzene or chloroform, at -20- +100 deg.C for 1-30hr to afford the compound of formulaI.

公开(公告)号：JPS5855457A

公开(公告)日：1983-04-01

申请号：JP15302881

申请日：1981-09-29

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  FUJIMURA SUSUMU ,  OKIMOTO KIYOMI ,  JIBIKI HIROSHI

IPC: A01N37/32 ,  C07D207/456

Abstract: NEW MATERIAL:The aminomaleimide of formulaI[R is H, 1-4C alkyl, 2-4C alkenyl, 7-10C aralkyl, or group of formula II (R is 1-4C alkyl or halogen; n is 0-3)]. EXAMPLE:3-Amino-4-carbamoylmaleimide. USE:Useful as pharmaceuticals, pesticides, and their intermediates. PROCESS:The compound of formulaIcan be prepared by reacting the cyanoformic acid ester of formula III with the malonamide of formula IV in the presence of zinc chloride and a tert-amine preferably in a solvent such as methylene chloride, benzene, etc. at 20-100 deg.C, and treating the resultant reaction product with an acidic aqueous solution, e.g. hydrochloric acid, p-toluenesulfonic acid, etc. at 0-30 deg.C. The amounts of the compound of formula IV and zinc chloride are preferably =1mol per 1mol of the compound of formula III, respectively.

公开(公告)号：JPS55162415A

公开(公告)日：1980-12-17

申请号：JP6949379

申请日：1979-06-05

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KITA JIYUNICHIROU ,  FUJIMURA SUSUMU

IPC: C01B32/80

Abstract: PURPOSE:To produce phosgene in a high yield by reacting CO and Cl2 in chlorobenzenes in the presence of triphenylphosphine oxide and/or triphenylphosphine dichloride as catalyst. CONSTITUTION:In the presence of the above-mentioned catalyst Cl2 is dissolved in chlorobenzene and/or dichlorobenzene, and by blowing gaseous CO into the soln. COCl2 is formed quantitatively. CO is preferably used in excess of Cl2, and the reaction temp. is usually 0-200 deg.C. The liq. reaction product is taken out of the CO atmosphere, and gaseous COCl2 is separated from the liq. product by making the pressure lower than the reaction pressure or other method. The COCl2-free liq. residue is recycled to the reaction of CO and Cl2, and repeated use of this liq. residue results in little lowering in COCl2 yield.

公开(公告)号：JPS55149293A

公开(公告)日：1980-11-20

申请号：JP5700879

申请日：1979-05-11

Applicant: UBE INDUSTRIES

Inventor： FUKUI KIYOSHI ,  KAKEYA NOBORU ,  KITA JIYUNICHIROU ,  FUJIMURA SUSUMU

IPC: C07F9/50 ,  B01J27/00 ,  B01J27/06 ,  B01J31/00 ,  B01J31/16 ,  C07B61/00

Abstract: PURPOSE:To obtain the titled compound useful as a reducing agent for the synthesis of organic compounds and as a disoxidant for nitro compounds in high yield, by reacting phosphine dihalogenide with hydrogen in the presence of a specific compound of a platinum group metal. CONSTITUTION:A compound of formula I (R is 1-18C alkyl or 6-14C aryl group; X is Cl, Br, I, etc.), e.g. trimethylphosphine dihalogenide, is reacted with hydrogen in the presence of one or more compounds selected from the group consisting of a halide of a platinum group metal, e.g. rhodium chloride, and a platinum group metal complex, e.g. dichlorobis (triphenylphosphine)palladium (II), at 100-250 deg.C to give a tertiary phosphine of formula II. For example, triphenylphosphine is obtained in 93% yield, using RhCl3 as a catalyst. EFFECT:A short reaction time even under a low pressure as low as 10kg/cm .

公开(公告)号：JPS53132586A

公开(公告)日：1978-11-18

申请号：JP4744877

申请日：1977-04-26

Applicant: UBE INDUSTRIES

Inventor： MAZAKI MITSUO ,  FUKUI KIYOSHI ,  KITA JIYUNICHIROU

IPC: C07D201/02

Abstract: PURPOSE:To prepare ?-caprolactam without ammonium sulfate by-production, from nitrobenzene, n-butanol, and tertiary lower-alkyl phosphine.