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公开(公告)号：TN2016000173A1
公开(公告)日：2017-10-06
申请号：TN2016000173
申请日：2014-11-12
Applicant: UCB BIOPHARMA SPRL
Inventor： ATHERFOLD PAUL ALAN , CESKA THOMAS ALLEN , FINNEY HELENE MARGARET , KEVORKIAN LARA , SARKAR KAUSHIK , SMITH BRYAN JOHN , TYSON KERRY LOUISE
Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.
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公开(公告)号：CA3006086A1
公开(公告)日：2017-06-08
申请号：CA3006086
申请日：2016-12-01
Applicant: UCB BIOPHARMA SPRL
Inventor： FINNEY HELENE MARGARET
IPC: C07K16/00 , C07K14/725 , C07K16/46
Abstract: The present invention is directed to a method of controlling and directing cells, for example to stimulate an immune response, inhibit an immune response, direct tissue regeneration or prevent tissue damage for therapeutic activity through the use of heterodimerically-tethered bispecific protein complex of formula A-X:Y-B. Component A may present X on the surface of a cell, may bind a protein (including a marker) expressed on the surface of an effector cell, or A-X is expressed on the surface of an effector cell, whilst B is specific to an epitope on target cell or tissue of interest. X:Y is a heterodimeric-tether which is formed by a binding interaction between X and Y, which together with A and B assists and effects the controlling and directing of the selected cells.
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公开(公告)号：CO2017000228A2
公开(公告)日：2017-04-10
申请号：CO2017000228
申请日：2017-01-11
Applicant: UCB BIOPHARMA SPRL
Inventor： FINNEY HELENE MARGARET , RAPECKI STEPHEN EDWARD , WRIGHT MICHAEL JOHN , TYSON KERRY
IPC: C07K16/28
Abstract: La presente descripción describe una molécula multiespecífica que comprende un dominio de unión específico al antígeno CD22 y un dominio de unión especifico al antígeno CD79a y/o CD79b, composiciones que comprenden la misma y el uso de ambos en el tratamiento, por ejemplo, el tratamiento de enfermedad autoinmunitaria.
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公开(公告)号：SG11201608882RA
公开(公告)日：2016-11-29
申请号：SG11201608882R
申请日：2015-05-28
Applicant: UCB BIOPHARMA SPRL
Inventor： FINNEY HELENE MARGARET , RAPECKI STEPHEN EDWARD , WRIGHT MICHAEL JOHN
Abstract: The present disclosure relates to a novel bispecific protein complex and a method of using the complexes to screen for synergistic or novel biological function. The bispecific format is particularly suitable for high-throughput screening because all of its components can be expressed from cells as individual units and the units can be assembled simply by mixing without employing conjugation or coupling chemistry,.
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公开(公告)号：AU2015265900A1
公开(公告)日：2016-11-10
申请号：AU2015265900
申请日：2015-05-28
Applicant: UCB BIOPHARMA SPRL
Inventor： FINNEY HELENE MARGARET , RAPECKI STEPHEN EDWARD , WRIGHT MICHAEL JOHN
Abstract: The present disclosure relates to a novel bispecific protein complex and a method of using the complexes to screen for synergistic or novel biological function. The bispecific format is particularly suitable for high-throughput screening because all of its components can be expressed from cells as individual units and the units can be assembled simply by mixing without employing conjugation or coupling chemistry,.
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Patent Agency Ranking
公开(公告)号：PL3068800T3
公开(公告)日：2020-02-28
申请号：PL14800000
申请日：2014-11-12
Applicant: UCB BIOPHARMA SPRL
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公开(公告)号：ES2732081T3
公开(公告)日：2019-11-20
申请号：ES13725298
申请日：2013-05-13
Applicant: UCB BIOPHARMA SPRL
Inventor： FINNEY HELENE MARGARET , LAWSON ALASTAIR DAVID GRIFFITHS , SHAW STEVAN GRAHAM , SMITH BRYAN JOHN , TYSON KERRY LOUISE , KEVORKIAN LARA , MEIER CHRISTOPH , ATHERFOLD PAUL , SARKAR KAUSHIK
Abstract: Un anticuerpo anti-FcRn o fragmento de unión a FcRn del mismo que tiene una cadena pesada que comprende la secuencia dada en la SEQ ID NO: 29 y una cadena ligera que comprende la secuencia dada en la SEQ ID NO: 15
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公开(公告)号：DK3068800T3
公开(公告)日：2019-10-21
申请号：DK14800000
申请日：2014-11-12
Applicant: UCB BIOPHARMA SPRL
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公开(公告)号：LT2850101T
公开(公告)日：2019-08-12
申请号：LT13725298
申请日：2013-05-13
Applicant: UCB BIOPHARMA SPRL
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公开(公告)号：PE20190229A1
公开(公告)日：2019-02-13
申请号：PE2019000226
申请日：2013-05-13
Applicant: UCB BIOPHARMA SPRL
Inventor： FINNEY HELENE MARGARET , LAWSON ALASTAIR DAVID GRIFFITHS , SHAW STEVAN GRAHAM , SMITH BRYAN JOHN , TYSON KERRY LOUISE , KEVORKIAN LARA , MEIER CHRISTOPH , SARKAR KAUSHIK , ATHERFOLD PAUL ALAN
Abstract: Se refiere a anticuerpos especificos frente a FcRn, a composiciones que los comprenden, a un procedimiento para expresar dichos anticuerpos, a ADN que codifica para dichos anticuerpos y a celulas huespedes que comprenden dicho ADN. Tambien se refiere a un ensayo para someter a prueba la capacidad de una molecula de prueba tal como una molecula de anticuerpo para bloquear la actividad de FcRn humano y en particular la capacidad de FcRn humano para reciclar IgG
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