公开(公告)号：NO305908B1

公开(公告)日：1999-08-16

申请号：NO940881

申请日：1994-03-11

Applicant: UCB SA

Inventor： COSSEMENT ERIC ,  BODSON GUY ,  GOBERT JEAN

IPC: C07D295/06 ,  A61K31/495 ,  A61P11/06 ,  A61P25/20 ,  A61P25/22 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07B53/00 ,  C07D295/04 ,  C07D295/073 ,  C07D295/08 ,  C07D295/088 ,  C07D295/22 ,  C07D295/26

公开(公告)号：NO990351A

公开(公告)日：1999-01-26

申请号：NO990351

申请日：1999-01-26

Applicant: UCB SA

Inventor： COSSEMENT ERIC ,  BODSON GUY ,  GOBERT JEAN

IPC: C07D295/06 ,  A61K31/495 ,  A61P11/06 ,  A61P25/20 ,  A61P25/22 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07B53/00 ,  C07D295/04 ,  C07D295/073 ,  C07D295/08 ,  C07D295/088 ,  C07D295/22 ,  C07D295/26 ,  C07D295/15

CPC classification number: A61K31/495 ,  C07D295/073 ,  C07D295/088 ,  C07D295/26

公开(公告)号：ES2109332T3

公开(公告)日：1998-01-16

申请号：ES92870101

申请日：1992-07-09

Applicant: UCB SA

Inventor： VAN KEULEN BEREND JAN ,  GOLSTEIN SOLO ,  COSSEMENT ERIC ,  GOBERT JEAN ,  WULFERT ERNST

IPC: A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61P11/00 ,  A61P11/06 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P29/00 ,  C07D251/12 ,  C07D251/14 ,  C07D251/16 ,  C07D251/18 ,  C07D251/22 ,  C07D401/04 ,  C07D403/04 ,  C07D411/04 ,  C07D413/04 ,  C07D417/04 ,  C07D498/08

Abstract: New cyclopropylamino-1,3,5-triazines and their salts, processes for their preparation and therapeutic compositions. These compounds correspond to the formula in which R1 = alkyl, cycloalkyl or alkylcycloalkyl, R2 = bis(2-hydroxyethyl)amino, 3-hydroxy-1-azetidinyl, 3-methoxy-1-azetidinyl, 3-oxo-1-azetidinyl, morpholino, 4-hydroxypiperidino, thiomorpholino, thiomorpholino S-oxide, thiomorpholino S,S-dioxide, 3-thiazolidinyl, 3-thiazolidinyl S-oxide, 3-thiazolidinyl S,S-dioxide or 8-oxa-3-azabicyclo[3.2.1]oct-3-yl. These compounds are useful in the treatment of disorders associated with Alzheimer's disease, Alzheimer-type senile dementias and all evolutive cognitive pathologies and in the treatment of depression, anxiety, mood disorders, inflammatory phenomena and asthma.

公开(公告)号：AT159719T

公开(公告)日：1997-11-15

申请号：AT92870101

申请日：1992-07-09

Applicant: UCB SA

Inventor： VAN KEULEN BEREND JAN ,  GOLSTEIN SOLO ,  COSSEMENT ERIC ,  GOBERT JEAN ,  WUELFERT ERNST

IPC: A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61P11/00 ,  A61P11/06 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P29/00 ,  C07D251/12 ,  C07D251/14 ,  C07D251/16 ,  C07D251/18 ,  C07D251/22 ,  C07D401/04 ,  C07D403/04 ,  C07D411/04 ,  C07D413/04 ,  C07D417/04 ,  C07D498/08

Abstract: New cyclopropylamino-1,3,5-triazines and their salts, processes for their preparation and therapeutic compositions. These compounds correspond to the formula in which R1 = alkyl, cycloalkyl or alkylcycloalkyl, R2 = bis(2-hydroxyethyl)amino, 3-hydroxy-1-azetidinyl, 3-methoxy-1-azetidinyl, 3-oxo-1-azetidinyl, morpholino, 4-hydroxypiperidino, thiomorpholino, thiomorpholino S-oxide, thiomorpholino S,S-dioxide, 3-thiazolidinyl, 3-thiazolidinyl S-oxide, 3-thiazolidinyl S,S-dioxide or 8-oxa-3-azabicyclo[3.2.1]oct-3-yl. These compounds are useful in the treatment of disorders associated with Alzheimer's disease, Alzheimer-type senile dementias and all evolutive cognitive pathologies and in the treatment of depression, anxiety, mood disorders, inflammatory phenomena and asthma.

公开(公告)号：LT3671B

公开(公告)日：1996-01-25

申请号：LTIP827

申请日：1993-08-03

Applicant: UCB SA

Inventor： COSSEMENT ERIC ,  GEERTS JEAN-PIERRE ,  GOBERT JEAN ,  MICHEL PHILIPPE ,  WUELFERT ERNST

IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  A61P29/00 ,  C07D233/54 ,  C07D233/64 ,  C07C233/64

Abstract: New substituted 1-(1H-imidazol-4-yl)alkyl-benzamides and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula wherein R1, R2=hydrogen or C1-C4-alkyl, R3=hydrogen, amino, hydroxyl, C1-C4-alkyl or C1-C4-hydroxyalkyl, R4=hydrogen or C1-C4-alkyl, or R3R4N=pyrrolidino, piperidino or morpholino, R5 and R6=hydrogen, hydroxyl, C1-C4-alkyl or C1-C4-alkoxy, at least one of R5 and R6 being other than hydrogen. These compounds are prepared either by reacting a nitrogen compound with an alkyl 1-(1H-imidazol-4-yl)alkyl-benzoate or with a 1-(1H-imidazol-4-yl)alkyl-benzoic acid, or by hydrolyzing in an acid medium a 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzonitrile. The compounds have anti-ischemic and alpha 2-adrenoceptor agonist activities.

公开(公告)号：LT3600B

公开(公告)日：1995-12-27

申请号：LTIP828

申请日：1993-08-03

Applicant: UCB SA

Inventor： BOLLEN ALEX ,  GOBERT JEAN ,  WUELFERT ERNST

IPC: C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K14/775 ,  C12N1/16 ,  C12N1/20 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C12R1/865

Abstract: The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.

公开(公告)号：HUT67813A

公开(公告)日：1995-05-29

申请号：HU9401574

申请日：1994-05-25

Applicant: UCB SA

Inventor： COSSEMENT ERIC ,  GOBERT JEAN ,  WUELFERT ERNST ,  MICHEL PHILIPPE

IPC: A61K31/4164 ,  A61K31/4174 ,  A61K31/415 ,  A61K31/4178 ,  A61P27/02 ,  A61P27/06 ,  C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D403/10

Abstract: 2-Hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximidamides and their salts, processes for their preparation and ophthalmic compositions containing them. These new compounds correspond to the general formula: in which R1 = hydrogen or C1-4 alkyl; R2 = hydrogen, hydroxyl, amino or C1-4 alkyl; R3 = hydrogen; or R2 and R3 = -CH2-CH2-. These are new compounds which are capable of lowering intraocular pressure and which can be used in the treatment and prevention of glaucoma.

公开(公告)号：ZA9407444B

公开(公告)日：1995-05-11

申请号：ZA9407444

申请日：1994-09-23

Applicant: UCB SA

Inventor： WULFERT ERNST ,  GOBERT JEAN ,  GOWER ALMA ,  COSSEMENT ERIC

IPC: C07D207/27 ,  A61K31/40 ,  A61K31/4015 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61K ,  C07D

CPC classification number: A61K31/40

公开(公告)号：LV10437A

公开(公告)日：1995-02-20

申请号：LV930548

申请日：1993-06-11

Applicant: UCB SA

Inventor： COSSEMENT ERIC ,  GEERTS JEAN-PIERRE ,  GOBERT JEAN ,  MICHEL PHILIPPE ,  WUELFERT ERNST

IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  A61P29/00 ,  C07D233/54 ,  C07D233/64

Abstract: New substituted 1-(1H-imidazol-4-yl)alkyl-benzamides and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula wherein R1, R2=hydrogen or C1-C4-alkyl, R3=hydrogen, amino, hydroxyl, C1-C4-alkyl or C1-C4-hydroxyalkyl, R4=hydrogen or C1-C4-alkyl, or R3R4N=pyrrolidino, piperidino or morpholino, R5 and R6=hydrogen, hydroxyl, C1-C4-alkyl or C1-C4-alkoxy, at least one of R5 and R6 being other than hydrogen. These compounds are prepared either by reacting a nitrogen compound with an alkyl 1-(1H-imidazol-4-yl)alkyl-benzoate or with a 1-(1H-imidazol-4-yl)alkyl-benzoic acid, or by hydrolyzing in an acid medium a 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzonitrile. The compounds have anti-ischemic and alpha 2-adrenoceptor agonist activities.

公开(公告)号：CZ124794A3

公开(公告)日：1994-12-15

申请号：CZ124794

申请日：1994-05-20

Applicant: UCB SA

Inventor： PHILIPPE MICHEL ,  COSSEMENT ERIC ,  GOBERT JEAN ,  WULFERT ERNST

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4178 ,  A61P27/02 ,  A61P27/06 ,  C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D403/10 ,  C07C257/18 ,  C07C257/22

Abstract: 2-Hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximidamides and their salts, processes for their preparation and ophthalmic compositions containing them. These new compounds correspond to the general formula: in which R1 = hydrogen or C1-4 alkyl; R2 = hydrogen, hydroxyl, amino or C1-4 alkyl; R3 = hydrogen; or R2 and R3 = -CH2-CH2-. These are new compounds which are capable of lowering intraocular pressure and which can be used in the treatment and prevention of glaucoma.