公开(公告)号：JP2000128829A

公开(公告)日：2000-05-09

申请号：JP29661799

申请日：1999-10-19

Applicant: UCB SA

Inventor： TWEEDY HARREL E

IPC: B01J21/16 ,  B01J3/00 ,  B01J31/02 ,  B01J31/10 ,  C07B61/00 ,  C07C67/08 ,  C07C67/62 ,  C07C69/54

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a (meth)acrylate ester and a polyester (meth)acrylate, mild for environments by significantly reducing or excluding the employment of a hydrocarbon solvent. SOLUTION: This method for producing an acrylate ester, a methacrylate ester, a polyester acrylate, a polyester methacrylate, or their mixture comprises reacting acrylic acid, methacrylic acid or their mixture with at least one monohydroxy group-containing compound and/or at least one polyhydroxy group-containing compound in the presence of a catalyst, a polymerization inbibitor and a compact phase carbon dioxide in a reactor.

公开(公告)号：JPH06220026A

公开(公告)日：1994-08-09

申请号：JP19870292

申请日：1992-07-24

Applicant: UCB SA

Inventor： BERENDO YAN BAN KEUREN ,  SORO GOORUDOSUTAIN ,  ERITSUKU KOSEMENTO ,  JIYAN GOBEERU ,  ERUNSUTO BUYURUFUERUTO

IPC: A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61P11/00 ,  A61P11/06 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P29/00 ,  C07D251/12 ,  C07D251/14 ,  C07D251/16 ,  C07D251/18 ,  C07D251/22 ,  C07D401/04 ,  C07D403/04 ,  C07D411/04 ,  C07D413/04 ,  C07D417/04 ,  C07D498/08

Abstract: New cyclopropylamino-1,3,5-triazines and their salts, processes for their preparation and therapeutic compositions. These compounds correspond to the formula in which R1 = alkyl, cycloalkyl or alkylcycloalkyl, R2 = bis(2-hydroxyethyl)amino, 3-hydroxy-1-azetidinyl, 3-methoxy-1-azetidinyl, 3-oxo-1-azetidinyl, morpholino, 4-hydroxypiperidino, thiomorpholino, thiomorpholino S-oxide, thiomorpholino S,S-dioxide, 3-thiazolidinyl, 3-thiazolidinyl S-oxide, 3-thiazolidinyl S,S-dioxide or 8-oxa-3-azabicyclo[3.2.1]oct-3-yl. These compounds are useful in the treatment of disorders associated with Alzheimer's disease, Alzheimer-type senile dementias and all evolutive cognitive pathologies and in the treatment of depression, anxiety, mood disorders, inflammatory phenomena and asthma.

公开(公告)号：JPH02108675A

公开(公告)日：1990-04-20

申请号：JP21054789

申请日：1989-08-15

Applicant: UCB SA

Inventor： ERITSUKU KOSUMAN ,  JIYAN GOBEERU ,  RORANDO BOIDEN ,  JIYATSUKU MACHIYUU

IPC: C07D413/04 ,  A61K31/53 ,  A61K31/535 ,  A61K31/5377 ,  A61P21/02 ,  A61P25/28 ,  A61P27/06 ,  C07D251/18

Abstract: New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, arylhydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or CONR4R5, or NR1R2=(hydroxyalkyl)alkyleneimino, R3=alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4=R5=hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, R2 is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.

公开(公告)号：JPS62267226A

公开(公告)日：1987-11-19

申请号：JP9060687

申请日：1987-04-13

Applicant: UCB SA

Inventor： JIYAN GOBEERU ,  RUNE BERUROE

IPC: A61K31/40 ,  A61K20060101 ,  A61K31/715 ,  A61P9/00

公开(公告)号：JPS61204281A

公开(公告)日：1986-09-10

申请号：JP4134486

申请日：1986-02-26

Applicant: UCB SA

Inventor： RUDORUFU ETSUCHI BOETSUKURAA

IPC: C08F20/00 ,  C08F20/10 ,  C08F26/00 ,  C08F220/00 ,  C08F220/20 ,  C08F226/00 ,  C09D4/00 ,  C09D133/08 ,  C09D171/00

公开(公告)号：JPS6131118B2

公开(公告)日：1986-07-17

申请号：JP8142876

申请日：1976-07-08

Applicant: UCB SA

Inventor： ARUBEERU ROTSUFU

IPC: A61K38/00 ,  A61P3/00 ,  C07D207/12 ,  C07D207/16 ,  C07K5/06 ,  C07K5/078

公开(公告)号：JPS6049626B2

公开(公告)日：1985-11-02

申请号：JP2691277

申请日：1977-03-11

Applicant: UCB SA

Inventor： UIRII KUUTO ,  JAN RAMIURU

IPC: C07B61/00 ,  B01J31/00 ,  B01J31/02 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/10 ,  C07C233/03

公开(公告)号：JPS6042248B2

公开(公告)日：1985-09-20

申请号：JP5423076

申请日：1976-05-12

Applicant: UCB SA

Inventor： MISHERU DO PUURUTERU ,  MARUKU KORUPAERU ,  HOORU DOYU FUURU ,  OOGUSUTO BURANKEN

IPC: G03F7/004 ,  C08F2/00 ,  C08F2/44 ,  C08F2/48 ,  C08F2/50 ,  C08F20/00 ,  C08F20/22 ,  C08F283/00 ,  C08F283/01 ,  C08F299/00 ,  C08F299/04 ,  C08G63/00 ,  C08G63/682 ,  C08G63/685 ,  C09D11/00 ,  C09D11/10 ,  C09D151/00 ,  C09D167/06 ,  G03F7/032 ,  G03F7/038

公开(公告)号：JPS5927348B2

公开(公告)日：1984-07-05

申请号：JP8521075

申请日：1975-07-11

Applicant: Ucb Sa

Inventor： JAN MARII RIITARUTO ,  GYUIDO MACHU

IPC: C07D307/60 ,  C07C51/56 ,  C07C57/145

CPC classification number: C07C51/56 ,  C07C57/145

公开(公告)号：JPS5828272B2

公开(公告)日：1983-06-15

申请号：JP5375474

申请日：1974-05-14

Applicant: UCB SA

Inventor： AUGUSUTO FURANKEN ,  PAURU DOFUORU ,  JATSUKU NOATO ,  JAN HORUDERITSUKU

IPC: C07C69/52 ,  C07C67/00 ,  C07C69/54 ,  C07C69/62 ,  C07C239/00 ,  C07C265/06 ,  C07C269/00 ,  C08F2/00 ,  C08F2/54 ,  C08F20/00 ,  C08F20/10 ,  C08F20/20 ,  C08F120/36 ,  C08F290/00 ,  C08F299/00 ,  C08G18/00 ,  C08G18/67 ,  C08G18/68 ,  C09D4/00 ,  C09D11/00 ,  C09D11/10 ,  C09D133/04 ,  C09D167/07 ,  C09D175/14