公开(公告)号：AU2002330938A1

公开(公告)日：2003-02-17

申请号：AU2002330938

申请日：2002-07-31

Applicant: UNIV NORTHEASTERN

Inventor： TORCHILIN VLADIMIR ,  WEISSIG VOLKMAR

IPC: A61K48/00 ,  C12N15/87 ,  C12N15/00 ,  A01N63/00 ,  A61K9/127 ,  A01N43/04 ,  A61K31/70

Abstract: The invention provides composition and methods for delivering a composition according to the invention comprising a wild-type (wt) mitochondrial DNA (mtDNA) molecule to a mammalian cell. The wt-mtDNA molecule is a functional mtDNA molecule that includes the entire mitochondrial genome. The wt-mtDNA molecule in the composition of the invention has a mitochondrial leader sequence (MLS) peptide attached to facilitate the uptake of the mtDNA molecule into a mitochondrion of the mammalian cell. The delivery of the wt-mtDNA/MLS peptide complex is used as a general replenishment therapy for conditions attributed to mtDNA defects, independent of the specific defect in the mtDNA.

公开(公告)号：WO2009012303A3

公开(公告)日：2010-08-12

申请号：PCT/US2008070164

申请日：2008-07-16

Applicant: UNIV NORTHEASTERN ,  LVOV YURI ,  TORCHILIN VLADIMIR ,  AGARWAL ANSHUL

Inventor： LVOV YURI ,  TORCHILIN VLADIMIR ,  AGARWAL ANSHUL

IPC: A61K9/51 ,  A61K47/48

CPC classification number: A61K9/5138 ,  A61K9/10 ,  A61K47/58 ,  A61K47/643 ,  A61K47/645 ,  A61K47/6933 ,  A61K47/6935 ,  B82Y5/00

Abstract: Stable colloid nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics.

Abstract translation: 公开了包含难溶性药物的稳定的胶体纳米颗粒，以及制备方法和使用这种纳米颗粒的方法，例如作为治疗剂和诊断剂。