公开(公告)号：BR102013033884A2

公开(公告)日：2015-12-01

申请号：BR102013033884

申请日：2013-12-30

Applicant: FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS FAPEMIG ,  FUNDAÇÃO UNIVERSIDADE DE BRASÍLIA ,  UNIV NORTHEASTERN ,  UNIV MINAS GERAIS

Inventor： FERREIRA LUCAS ANTÔNIO MIRANDA ,  OLIVEIRA MÔNICA CRISTINA DE ,  AZEVEDO RICARDO BENTES DE ,  MUSSI SAMUEL VIDAL ,  TORCHILIN VLADIMIR

IPC: A61K9/51 ,  A61K31/704 ,  A61K47/44 ,  B82Y5/00

Abstract: composição farmacêutica de carreadores llpídlcos nanoestruturados de antraciclinas e ácidos graxos poliinsaturados co-encapsulados, processo de obtenqao e uso. a presente invenção descreve composições farmacêuticas de carreadores lipídicos nanoestruturados contendo antraciclinas na forma de par iônico com um ácido graxo e co-encapsulação de um ácido graxo poliinsaturado dotado de atividade antitumoral. a invenção propõe também o processo de obtenção desses carreadores e composições farmacêuticas contendo os mesmos, bem como o uso dessas composições no tratamento quimioterépico antitumoral. a composição proposta visa não somente a diminuição da toxicidade sistêmica e dos efeitos adversos causados pelas antraciclinas, como também alcançar maior seletividade e aumento da citotoxicidade para as células tumorais, através do sinergismo promovido pela co-encapsulação de um acido graxo poliinsa atividade antitumoral, como o dha.

公开(公告)号：AU2003211103A1

公开(公告)日：2003-09-04

申请号：AU2003211103

申请日：2003-02-13

Applicant: UNIV NORTHEASTERN

Inventor： TORCHILIN VLADIMIR ,  RAMMOHAN RAM ,  LEVCHENKO TATIANA ,  VOLODINA NATALIA

IPC: A61K9/127 ,  A61K39/21 ,  A61K39/245 ,  A61K47/48 ,  A61K48/00 ,  C12N15/85

Abstract: The preparation and use of a transducing polypeptide (TP)- lipid vesicle complex having a small proportion of positively charged (cationic) lipids in the make-up of the lipid vesicle, e.g., liposome, for safe and efficient intracellular delivery of therapeutic agents, such as proteins, DNA, small molecules and/or other drugs, into a cell of a higher organism, in vitro or in vivo is disclosed. The delivery system of the invention results in increased efficacy of intracellular delivery of such agents, bypassing the endocytotic pathway of intracellular delivery while at the same time minimizing the toxicity of the delivery system towards the recipient cells.

公开(公告)号：CA2694089A1

公开(公告)日：2009-01-22

申请号：CA2694089

申请日：2008-07-16

Applicant: UNIV NORTHEASTERN

Inventor： LVOV YURI ,  TORCHILIN VLADIMIR ,  AGARWAL ANSHUL

IPC: A61K9/51 ,  A61K47/48

Abstract: Stable colloid nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics.

公开(公告)号：EP2171095A4

公开(公告)日：2012-07-11

申请号：EP08826166

申请日：2008-07-07

Applicant: UNIV NORTHEASTERN

Inventor： TORCHILIN VLADIMIR ,  LEVCHENKO TATYANA S

IPC: A61K47/48 ,  A61K9/107 ,  A61P43/00 ,  C12N15/11

CPC classification number: A61K9/1075 ,  A61K47/542 ,  A61K47/543 ,  A61K47/544 ,  A61K47/554 ,  A61K47/6907 ,  C12N15/111 ,  C12N2320/32

公开(公告)号：EP2410992A4

公开(公告)日：2013-09-11

申请号：EP10756933

申请日：2010-03-26

Applicant: UNIV NORTHEASTERN ,  UNIV PADUA

Inventor： TORCHILIN VLADIMIR ,  MUSACCHIO TIZIANA ,  SALMASO STEFANO

IPC: A61K9/127 ,  A61K9/00 ,  A61K9/107 ,  A61K31/375 ,  A61K47/48

CPC classification number: A61K9/0085 ,  A61K9/107 ,  A61K9/1271 ,  A61K31/375 ,  A61K47/6907 ,  A61K47/6911

公开(公告)号：EP2972362A4

公开(公告)日：2016-11-23

申请号：EP14764307

申请日：2014-03-14

Applicant: UNIV NORTHEASTERN

Inventor： MALIMA ASANTERABI ,  BUSNAINA AHMED ,  SIAVOSHI SALOME ,  SOMU SIVASUBRAMANIAN ,  YILMAZ CIHAN ,  MUSACCHIO TIZIANA ,  UPPONI JAYDEV ,  TORCHILIN VLADIMIR

IPC: G01N33/543 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61M5/00 ,  B82Y30/00 ,  C12M1/34 ,  C12Q1/00 ,  G01N33/566

CPC classification number: G01N33/54346 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/6852 ,  B82Y30/00

公开(公告)号：WO2014143931A3

公开(公告)日：2015-11-05

申请号：PCT/US2014028118

申请日：2014-03-14

Applicant: UNIV NORTHEASTERN

Inventor： MALIMA ASANTERABI ,  BUSNAINA AHMED ,  SIAVOSHI SALOME ,  SOMU SIVASUBRAMANIAN ,  YILMAZ CIHAN ,  MUSACCHIO TIZIANA ,  UPPONI JAYDEV ,  TORCHILIN VLADIMIR

IPC: G01N33/00 ,  A61M5/00 ,  C12M1/34 ,  C12Q1/00 ,  G01N33/566

CPC classification number: G01N33/54346 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/6852 ,  B82Y30/00

Abstract: Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described.

Abstract translation: 描述了作为生物传感器的纳米基质，制备这种纳米基质的方法，以及使用这种纳米基质来检测生物标志物的方法。

公开(公告)号：WO2009012303A9

公开(公告)日：2009-03-05

申请号：PCT/US2008070164

申请日：2008-07-16

Applicant: UNIV NORTHEASTERN ,  LVOV YURI ,  TORCHILIN VLADIMIR ,  AGARWAL ANSHUL

Inventor： LVOV YURI ,  TORCHILIN VLADIMIR ,  AGARWAL ANSHUL

IPC: A61K9/51 ,  A61K47/48

CPC classification number: A61K9/5138 ,  A61K9/10 ,  A61K47/58 ,  A61K47/643 ,  A61K47/645 ,  A61K47/6933 ,  A61K47/6935 ,  B82Y5/00

Abstract: Stable colloid nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics.

Abstract translation: 公开了包含难溶药物的稳定的胶体纳米颗粒，以及制备和使用这种纳米颗粒的方法，例如作为治疗剂和诊断剂。

公开(公告)号：CA2756581A1

公开(公告)日：2010-09-30

申请号：CA2756581

申请日：2010-03-26

Applicant: UNIV NORTHEASTERN ,  UNIV PADUA

Inventor： TORCHILIN VLADIMIR ,  MUSACCHIO TIZIANA ,  SALMASO STEFANO

IPC: A61K9/127

Abstract: Ascorbate-conjugated liposomes and micelles, methods of making such liposomes and micelles, and methods of using such liposomes and micelles, such as for delivery of therapeutic and detection agents to the brain, are described.

公开(公告)号：CA2692748A1

公开(公告)日：2009-01-15

申请号：CA2692748

申请日：2008-07-07

Applicant: UNIV NORTHEASTERN

Inventor： TORCHILIN VLADIMIR ,  LEVCHENKO TATYANA S

IPC: C12Q1/68

Abstract: Disclosed are improved pharmaceutical formulations for the delivery of RNA interference agents, such as antisense RNA, micro-RNA and siRNA. The formulations employ mixed micelles including amphipathic conjugates of the iRNA agents and amphipathic micelle-forming molecules with extended hydrophilic chains. Also disclosed are methods of using the pharmaceutical formulations to increase delivery of an iRNA agent to an intracellular target, and to decrease extracellular nuclease degradation of an iRNA agent in the formulations.