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公开(公告)号：AU4109996A
公开(公告)日：1996-06-06
申请号：AU4109996
申请日：1995-11-13
Applicant: VERTEX PHARMA
Inventor： ZELLE ROBERT E , HARDING MATTHEW W
IPC: C07C237/00 , C07D333/06 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/395 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P35/00 , C07C231/02 , C07C237/22 , C07C309/51 , C07C309/59 , C07C317/28 , C07C323/41 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D233/54 , C07D233/90 , C07D261/08 , C07D263/32 , C07D271/04 , C07D277/20 , C07D277/22 , C07D277/38 , C07D277/64 , C07D333/36 , C07D521/00 , C07C237/02 , C07D213/81
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公开(公告)号：CA2224198A1
公开(公告)日：1996-05-23
申请号：CA2224198
申请日：1995-11-13
Applicant: VERTEX PHARMA
Inventor： HARDING MATTHEW W , ZELLE ROBERT E
IPC: C07C237/00 , C07D333/06 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/395 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P35/00 , C07C231/02 , C07C237/22 , C07C309/51 , C07C309/59 , C07C317/28 , C07C323/41 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D233/54 , C07D233/90 , C07D261/08 , C07D263/32 , C07D271/04 , C07D277/20 , C07D277/22 , C07D277/38 , C07D277/64 , C07D333/36 , C07D521/00 , A61K31/195 , A61K31/33 , C07D207/337 , C07D209/20 , C07D209/44 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/61 , C07D307/54 , C07D333/24 , C07D471/04
Abstract: The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multidrug resistant cancer therapy.
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公开(公告)号：CA2545733A1
公开(公告)日：2005-05-26
申请号：CA2545733
申请日：2004-11-10
Applicant: VERTEX PHARMA
Inventor： HARDING MATTHEW W , ROY AMIT , ALAM JOHN , RANDLE JOHN
IPC: G01N33/68 , A61K38/04 , C07D207/16 , C07D405/12 , G01N33/00
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公开(公告)号：AU2004290413A1
公开(公告)日：2005-05-26
申请号：AU2004290413
申请日：2004-11-10
Applicant: VERTEX PHARMA
Inventor： ALAM JOHN , ROY AMIT , HARDING MATTHEW W , RANDLE JOHN
IPC: G01N33/68 , A61K38/04 , C07D207/16 , C07D405/12 , G01N33/00
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公开(公告)号：AT210119T
公开(公告)日：2001-12-15
申请号：AT95914866
申请日：1995-03-23
Applicant: VERTEX PHARMA
Inventor： ZELLE ROBERT EDWARD , HARDING MATTHEW W
IPC: A61K31/4406 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/535 , A61P43/00 , C07C271/18 , C07C279/10 , C07C333/04 , C07C335/06 , C07D211/60 , C07D213/30 , C07D213/55 , C07D401/12 , C07D401/14 , A61K31/44 , C07C271/54 , C07C275/34
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Patent Agency Ranking
公开(公告)号：SK282069B6
公开(公告)日：2001-10-08
申请号：SK61197
申请日：1995-11-13
Applicant: VERTEX PHARMA
Inventor： ZELLE ROBERT E , HARDING MATTHEW W
IPC: C07C237/00 , C07D333/06 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/395 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P35/00 , C07C231/02 , C07C237/22 , C07C309/51 , C07C309/59 , C07C317/28 , C07C323/41 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D233/54 , C07D233/90 , C07D261/08 , C07D263/32 , C07D271/04 , C07D277/20 , C07D277/22 , C07D277/38 , C07D277/64 , C07D333/36 , C07D521/00 , C07C237/02 , C07D213/81
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公开(公告)号：AU704475B2
公开(公告)日：1999-04-22
申请号：AU2194395
申请日：1995-03-23
Applicant: VERTEX PHARMA
Inventor： ZELLE ROBERT EDWARD , HARDING MATTHEW W
IPC: A61K31/4406 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/535 , A61P43/00 , C07C271/18 , C07C279/10 , C07C333/04 , C07C335/06 , C07D211/60 , C07D213/30 , C07D213/55 , C07D401/12 , C07D401/14 , C07D213/65 , A61K31/17 , A61K31/27 , A61K31/44 , C07C271/54 , C07C275/34 , C07D215/20
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公开(公告)号：NZ296474A
公开(公告)日：1999-01-28
申请号：NZ29647495
申请日：1995-11-13
Applicant: VERTEX PHARMA
Inventor： ZELLE ROBERT E , HARDING MATTHEW W
IPC: C07C237/00 , C07D333/06 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/395 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P35/00 , C07C231/02 , C07C237/22 , C07C309/51 , C07C309/59 , C07C317/28 , C07C323/41 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D233/54 , C07D233/90 , C07D261/08 , C07D263/32 , C07D271/04 , C07D277/20 , C07D277/22 , C07D277/38 , C07D277/64 , C07D333/36 , C07D521/00 , A61K31/415 , C07D233/61
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公开(公告)号：SK61197A3
公开(公告)日：1997-11-05
申请号：SK61197
申请日：1995-11-13
Applicant: VERTEX PHARMA
Inventor： ZELLE ROBERT E , HARDING MATTHEW W
IPC: C07C237/00 , C07D333/06 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/395 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P35/00 , C07C231/02 , C07C237/22 , C07C309/51 , C07C309/59 , C07C317/28 , C07C323/41 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D233/54 , C07D233/90 , C07D261/08 , C07D263/32 , C07D271/04 , C07D277/20 , C07D277/22 , C07D277/38 , C07D277/64 , C07D333/36 , C07D521/00 , C07C237/02 , C07D213/81
Abstract: The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
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公开(公告)号：FI972086A0
公开(公告)日：1997-05-15
申请号：FI972086
申请日：1997-05-15
Applicant: VERTEX PHARMA
Inventor： ZELLE ROBERT E , HARDING MATTHEW W
IPC: C07C237/00 , C07D333/06 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/395 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P35/00 , C07C231/02 , C07C237/22 , C07C309/51 , C07C309/59 , C07C317/28 , C07C323/41 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D233/54 , C07D233/90 , C07D261/08 , C07D263/32 , C07D271/04 , C07D277/20 , C07D277/22 , C07D277/38 , C07D277/64 , C07D333/36 , C07D521/00 , C07C
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