公开(公告)号：NZ737090A

公开(公告)日：2019-05-31

申请号：NZ73709012

申请日：2012-09-28

Applicant: VERTEX PHARMA

Inventor： DURRANT STEVEN ,  CHARRIER JEAN-DAMIEN ,  STUDLEY JOHN ,  PIERARD FRANCOISE YVONNE THEODORA MARIE ,  LITTLER BENJAMIN JOSEPH ,  HUGHES ROBERT MICHAEL ,  SIESEL DAVID ANDREW ,  URBINA ARMANDO ,  SHI YI ,  ANGELL PAUL

IPC: C07D413/04 ,  A61K31/497 ,  A61P35/00

Abstract: The present disclosure relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present disclosure also relates to compounds useful as inhibitors of ATR protein kinase. The disclosure relates to pharmaceutically acceptable compositions comprising the compounds; methods of treating of various diseases, disorders, and conditions using the compounds; processes for preparing the compounds; intermediates for the preparation of the compounds; and solid forms of the compounds. The compounds have formula (I) or (II) wherein the variables are as defined herein.

公开(公告)号：LT4013741T

公开(公告)日：2024-06-25

申请号：LTUS2020046116

申请日：2020-08-13

Applicant: VERTEX PHARMA

Inventor： ANGELL PAUL ,  COCHRAN JOHN E ,  LITTLER BENJAMIN J ,  SIESEL DAVID ANDREW ,  URBINA ARMANDO ,  ANDERSON COREY DON ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN ,  GROOTENHUIS PETER ,  HADIDA RUAH SARA SABINA ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SWIFT SARA E ,  ZHOU JINGLAN

IPC: C07D207/08 ,  C07D207/09 ,  C07D213/61 ,  C07D213/62 ,  C07D213/70 ,  C07D213/74 ,  C07D231/20 ,  C07D401/04 ,  C07D401/14 ,  C07D513/22

公开(公告)号：CA2850566C

公开(公告)日：2022-05-03

申请号：CA2850566

申请日：2012-09-28

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  STUDLEY JOHN ,  PIERARD FRANCOISE YVONNE THEODORA MARIE ,  DURRANT STEVEN JOHN ,  LITTLER BENJAMIN JOSEPH ,  HUGHES ROBERT MICHAEL ,  SIESEL DAVID ANDREW ,  ANGELL PAUL ,  URBINA ARMANDO ,  SHI YI

IPC: C07C269/06

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules of formula I or II: which may be useful in the treatment of cancer. Compounds of the invention may be prepared via a compound of formula 4-11: which may be prepared by reacting a compound of formula 4-i: under suitable chlorooxime formation conditions to form the compound of formula 4-ii.

公开(公告)号：BR112022002604A2

公开(公告)日：2022-05-03

申请号：BR112022002604

申请日：2020-08-13

Applicant: VERTEX PHARMA

Inventor： URBINA ARMANDO ,  BENJAMIN J LITTLER ,  FRIEMAN BRYAN ,  COREY DON ANDERSON ,  DAVID ANDREW SIESEL ,  PIERRE FABRICE ,  MCCARTNEY JASON ,  JEREMY J CLEMENS ,  ZHOU JINGLAN ,  JOHN E COCHRAN ,  MARK THOMAS MILLER ,  ANGELL PAUL ,  GROOTENHUIS PETER ,  PARASELLI PRASUNA ,  SARA E SWIFT ,  SARA SABINA HADIDA RUAH ,  CLEVELAND THOMAS ,  TIMOTHY RICHARD COON

IPC: C07D207/08 ,  C07D207/09 ,  C07D213/61 ,  C07D213/62 ,  C07D213/70 ,  C07D213/74 ,  C07D231/20 ,  C07D401/04 ,  C07D401/14 ,  C07D513/22

Abstract: processo de produção de moduladores de cftr. a divulgação fornece processos para sintetizar o composto i e sais farmaceuticamente aceitáveis deste.

公开(公告)号：NZ623089A

公开(公告)日：2016-05-27

申请号：NZ62308912

申请日：2012-09-28

Applicant: VERTEX PHARMA

Inventor： DURRANT STEVEN JOHN ,  CHARRIER JEAN-DAMIEN ,  STUDLEY JOHN ,  PIERARD FRANCOISE YVONNE THEODORA MARIE ,  LITTLER BENJAMIN JOSEPH ,  HUGHES ROBERT MICHAEL ,  SIESEL DAVID ANDREW ,  URBINA ARMANDO ,  SHI YI ,  ANGELL PAUL

IPC: C07D413/04 ,  A61K31/497 ,  A61P35/00

Abstract: The present disclosure relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present disclosure also relates to compounds useful as inhibitors of ATR protein kinase. The disclosure relates to pharmaceutically acceptable compositions comprising the compounds; methods of treating of various diseases, disorders, and conditions using the compounds; processes for preparing the compounds; intermediates for the preparation of the compounds; and solid forms of the compounds. The compounds have formula (I) or (II) wherein the variables are as defined herein.

公开(公告)号：AU2012315615A1

公开(公告)日：2014-04-17

申请号：AU2012315615

申请日：2012-09-28

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  STUDLEY JOHN ,  PIERARD FRANCOISE YVONNE THEODORA MARIE ,  DURRANT STEVEN JOHN ,  LITTLER BENJAMIN JOSEPH ,  HUGHES ROBERT MICHAEL ,  SIESEL DAVID ANDREW ,  ANGELL PAUL ,  URBINA ARMANDO ,  SHI YI

IPC: C07D413/04 ,  A61K31/497 ,  A61P35/00

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula (I) or (II) wherein the variables are as defined herein.

公开(公告)号：CA2850564A1

公开(公告)日：2013-04-04

申请号：CA2850564

申请日：2012-09-28

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN ,  PIERARD FRANCOISE YVONNE THEODORA MARIE ,  DURRANT STEVEN JOHN ,  LITTLER BENJAMIN JOSEPH ,  ANGELL PAUL ,  HUGHES ROBERT MICHAEL ,  SIESEL DAVID ANDREW ,  URBINA ARMANDO ,  ZWICKER CARL ,  LOCONTE NICHOLAS ,  BARDER TIMOTHY

IPC: C07D413/14 ,  A61K31/497 ,  A61P35/00

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I-l : wherein the variables are as defined herein. Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

公开(公告)号：PL4013741T3

公开(公告)日：2024-08-26

申请号：PL20761961

申请日：2020-08-13

Applicant: VERTEX PHARMA

Inventor： ANGELL PAUL ,  COCHRAN JOHN E ,  LITTLER BENJAMIN J ,  SIESEL DAVID ANDREW ,  URBINA ARMANDO ,  ANDERSON COREY DON ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN ,  GROOTENHUIS PETER ,  HADIDA RUAH SARA SABINA ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SWIFT SARA E ,  ZHOU JINGLAN

IPC: C07D207/08 ,  C07D207/09 ,  C07D213/61 ,  C07D213/62 ,  C07D213/70 ,  C07D213/74 ,  C07D231/20 ,  C07D401/04 ,  C07D401/14 ,  C07D513/22

公开(公告)号：AU2020330570A8

公开(公告)日：2022-03-31

申请号：AU2020330570

申请日：2020-08-13

Applicant: VERTEX PHARMA

Inventor： ANGELL PAUL ,  COCHRAN JOHN E ,  LITTLER BENJAMIN J ,  SIESEL DAVID ANDREW ,  URBINA ARMANDO ,  ANDERSON COREY DON ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN ,  GROOTENHUIS PETER ,  HADIDA RUAH SARA SABINA ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SWIFT SARA E ,  ZHOU JINGLAN

IPC: C07D207/08 ,  C07D207/09 ,  C07D213/61 ,  C07D213/62 ,  C07D213/70 ,  C07D213/74 ,  C07D231/20 ,  C07D401/04 ,  C07D401/14 ,  C07D513/22

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

公开(公告)号：AU2019210688B2

公开(公告)日：2021-05-27

申请号：AU2019210688

申请日：2019-08-05

Applicant: VERTEX PHARMA

Inventor： ANGELL PAUL ,  URBINA ARMANDO ,  CHARRIER JEAN-DAMIEN ,  STUDLEY JOHN ,  PIERARD FRANCOISE YVONNE THEODORA MARIE ,  DURRANT STEVEN JOHN ,  LITTLER BENJAMIN JOSEPH ,  HUGHES ROBERT MICHAEL ,  SIESEL DAVID ANDREW ,  SHI YI

IPC: C07D413/04 ,  A61K31/497 ,  A61P35/00

Abstract: Abstract The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: NH2 0.- N 2 ~ R9bR1 N _LH R R4 R3a NH2 R R 3c Ric R4 Rib wherein the variables are as defined herein.