16.
    发明专利
    未知

    公开(公告)号:SE413506B

    公开(公告)日:1980-06-02

    申请号:SE7506083

    申请日:1975-05-28

    Applicant: WELLCOME FOUND

    Inventor: STUART A PATERSON T

    Abstract: 1413471 2,4-Diamino-5-benzyl pyrimidines WELLCOME FOUNDATION Ltd 12 Oct 1972 [12 Oct 1971 10 Dec 1971] 47492/71 and 57512/71 Heading C2C Compounds having the general formula wherein one of Q 1 and Q 2 is a 2,4-diaminopyrimidin.5-yl methyl group, R 1 , R 2 , R 3 and the other Q group are hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, and R 6 is hydrogen or alkyl, provided that when Q 2 is the pyrimidyl group Q 1 is not hydrogen; may be prepared by reacting a compound of formula wherein R 71 is hydroxyl, halogen, or the anionic residue of a carboxylic or sulphonic acid, with a compound of the formula wherein at least one of R 4 and R 5 is hydrogen and the other is hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, in a polar non-phenolic solvent capable of dissolving both reactants, and, when R 6 is alkyl, alkylating the product with an alkylating agent R 6 Z wherein Z is a reactive atom or group. The invention further comprises compounds having the general formula wherein whenever Q 1 is 2,4-diaminopyrimidin- 5-yl-methyl and whenever at least one of R 3 and Q 2 is alkyl or alkoxy, then at least one of R 1 and R 2 is other than hydrogen.

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