公开(公告)号：ZA7207250B

公开(公告)日：1974-05-29

申请号：ZA7207250

申请日：1972-10-11

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: A61K31/505 ,  C07D20060101 ,  C07D239/48 ,  C07D239/49 ,  C07D

公开(公告)号：SE409705B

公开(公告)日：1979-09-03

申请号：SE7406661

申请日：1974-05-20

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: C07D239/49 ,  A61K31/505 ,  C07C45/68 ,  C07D239/42 ,  C07D239/48 ,  C07C121/66 ,  C07C121/75 ,  C07C121/84 ,  C07C149/00 ,  C07D321/00

公开(公告)号：ZA717047B

公开(公告)日：1973-06-27

申请号：ZA717047

申请日：1971-10-21

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T ,  ROTH B

IPC: A61K20060101 ,  C07D20060101 ,  C07D239/49 ,  C07D ,  A61K

公开(公告)号：NO771463A

公开(公告)日：1973-04-13

申请号：NO771463

申请日：1977-04-27

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: C07D20060101 ,  C07D239/48 ,  C07D

公开(公告)号：YU186678A

公开(公告)日：1982-10-31

申请号：YU186678

申请日：1978-08-01

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: A61K31/00 ,  A61K31/505 ,  C07D239/00 ,  C07D239/48

公开(公告)号：SE413506B

公开(公告)日：1980-06-02

申请号：SE7506083

申请日：1975-05-28

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: B01J23/00 ,  B01J25/00 ,  B01J31/00 ,  C07B61/00 ,  C07D239/48 ,  C07D239/49

Abstract: 1413471 2,4-Diamino-5-benzyl pyrimidines WELLCOME FOUNDATION Ltd 12 Oct 1972 [12 Oct 1971 10 Dec 1971] 47492/71 and 57512/71 Heading C2C Compounds having the general formula wherein one of Q 1 and Q 2 is a 2,4-diaminopyrimidin.5-yl methyl group, R 1 , R 2 , R 3 and the other Q group are hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, and R 6 is hydrogen or alkyl, provided that when Q 2 is the pyrimidyl group Q 1 is not hydrogen; may be prepared by reacting a compound of formula wherein R 71 is hydroxyl, halogen, or the anionic residue of a carboxylic or sulphonic acid, with a compound of the formula wherein at least one of R 4 and R 5 is hydrogen and the other is hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, in a polar non-phenolic solvent capable of dissolving both reactants, and, when R 6 is alkyl, alkylating the product with an alkylating agent R 6 Z wherein Z is a reactive atom or group. The invention further comprises compounds having the general formula wherein whenever Q 1 is 2,4-diaminopyrimidin- 5-yl-methyl and whenever at least one of R 3 and Q 2 is alkyl or alkoxy, then at least one of R 1 and R 2 is other than hydrogen.

公开(公告)号：PH12078A

公开(公告)日：1978-10-30

申请号：PH14148

申请日：1972-12-08

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: C07D239/00

公开(公告)号：NO134837B

公开(公告)日：1976-09-13

申请号：NO391071

申请日：1971-10-21

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: A61K31/00 ,  A61K31/505 ,  C07D239/00 ,  C07D239/48

公开(公告)号：DK132174C

公开(公告)日：1976-03-29

申请号：DK513771

申请日：1971-10-21

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: C07D239/49 ,  A61K31/505 ,  C07C45/68 ,  C07D239/42 ,  C07D239/48

公开(公告)号：DK132174B

公开(公告)日：1975-11-03

申请号：DK513771

申请日：1971-10-21

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: C07D239/49 ,  A61K31/505 ,  C07C45/68 ,  C07D239/42 ,  C07D239/48