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    NOVEL MEDICAL APPLICATION OF LIPID DERIVATIVES OF DOPAMINE AND THE METHODS OF THEIR PRODUCTION
    12.
    发明申请
    NOVEL MEDICAL APPLICATION OF LIPID DERIVATIVES OF DOPAMINE AND THE METHODS OF THEIR PRODUCTION 有权
    多巴胺脂质衍生物的新医学应用及其生产方法

    公开(公告)号：US20130131361A1

    公开(公告)日：2013-05-23

    申请号：US13303935

    申请日：2011-11-23

    Applicant: Mieczyslaw Pokorski ,  Dominika Zajac ,  Zbigniew Czarnocki ,  Piotr Roszkowski

    Inventor： Mieczyslaw Pokorski ,  Dominika Zajac ,  Zbigniew Czarnocki ,  Piotr Roszkowski

    IPC: C07C233/27 ,  C07C231/10 ,  C12P7/64

    CPC classification number: C07C231/02 ,  A61K31/165 ,  C12P13/02 ,  C12Y201/01006 ,  C07C233/20

    Abstract: A medical application of N-oleoyl-dopamine and 3′-O-methyl-N-oleoyl-dopamine for the production of a medication for treatment or prophylaxis of disturbances or states due to deficiency of dopamine, preferably chosen from the group covering oxygen deficiencies (hypoxia) in anesthetized and awake mammals, breathing with atmospheric oxygen (normoxia), for the respiratory responses to hypoxia in mammals, lack of dopamine binding to the membrane system in the mammalian brain, disturbances in metabolic pathways of dopamine metabolism, states of dopamine deficiencies provoked by morbid or genetic factors as well as under condition connected to the physiological process of aging of the organism, through the systemic introduction of the compound to the mammalian organism. A method of production of 3′-O-methyl-N-oleoyl-dopamine in vitro is also disclosed.

    Abstract translation: N-油酰多巴胺和3'-O-甲基-N-油酰多巴胺的药物应用用于制备用于治疗或预防由于多巴胺缺乏引起的干扰或状态的药物，优选选自涵盖氧缺乏的组 （缺氧）在麻醉和清醒的哺乳动物中，呼吸大气中的氧气（常氧），对哺乳动物的缺氧的呼吸反应，缺乏多巴胺与哺乳动物脑膜系统的结合，多巴胺代谢途径的紊乱，多巴胺的状态 通过将化合物全面引入哺乳动物生物体中，由病态或遗传因素引起的缺陷以及与生物衰老的生理过程相关的条件下。 还公开了一种在体外制备3'-O-甲基-N-油酰 - 多巴胺的方法。

    Medical application of lipid derivatives of dopamine and the methods of their production
    18.
    发明授权
    Medical application of lipid derivatives of dopamine and the methods of their production 有权
    多巴胺脂质衍生物的医学应用及其制备方法

    公开(公告)号：US08697898B2

    公开(公告)日：2014-04-15

    申请号：US13303935

    申请日：2011-11-23

    Applicant: Mieczyslaw Pokorski ,  Dominika Zajac ,  Zbigniew Czarnocki ,  Piotr Roszkowski

    Inventor： Mieczyslaw Pokorski ,  Dominika Zajac ,  Zbigniew Czarnocki ,  Piotr Roszkowski

    IPC: C07C231/00 ,  C07C233/00

    CPC classification number: C07C231/02 ,  A61K31/165 ,  C12P13/02 ,  C12Y201/01006 ,  C07C233/20

    Abstract: A medical application of N-oleoyl-dopamine and 3′-O-methyl-N-oleoyl-dopamine for the production of a medication for treatment or prophylaxis of disturbances or states due to deficiency of dopamine, preferably chosen from the group covering oxygen deficiencies (hypoxia) in anesthetized and awake mammals, breathing with atmospheric oxygen (normoxia), for the respiratory responses to hypoxia in mammals, lack of dopamine binding to the membrane system in the mammalian brain, disturbances in metabolic pathways of dopamine metabolism, states of dopamine deficiencies provoked by morbid or genetic factors as well as under condition connected to the physiological process of aging of the organism, through the systemic introduction of the compound to the mammalian organism. A method of production of 3′-O-methyl-N-oleoyl-dopamine in vitro is also disclosed.

    Abstract translation: N-油酰多巴胺和3'-O-甲基-N-油酰多巴胺的药物应用用于制备用于治疗或预防由于多巴胺缺乏引起的干扰或状态的药物，优选选自涵盖氧缺乏的组 （缺氧）在麻醉和清醒的哺乳动物中，呼吸大气中的氧气（常氧），对哺乳动物的缺氧的呼吸反应，缺乏多巴胺与哺乳动物脑膜系统的结合，多巴胺代谢途径的紊乱，多巴胺的状态 通过将化合物全面引入哺乳动物生物体中，由病态或遗传因素引起的缺陷以及与生物衰老的生理过程相关的条件下。 还公开了一种在体外制备3'-O-甲基-N-油酰 - 多巴胺的方法。

    Methods and Materials for Determining Pain Sensitivity and Predicting and Treating Related Disorders
    19.
    发明申请
    Methods and Materials for Determining Pain Sensitivity and Predicting and Treating Related Disorders 审中-公开
    用于确定疼痛敏感性和预测和治疗相关疾病的方法和材料

    公开(公告)号：US20130244233A1

    公开(公告)日：2013-09-19

    申请号：US13624608

    申请日：2012-09-21

    Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

    Inventor： Luda B. Diatchenko ,  William Maixner ,  Gary D. Slade ,  Andrea Gail Neely

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6881 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  C12Y201/01006 ,  G16B20/00 ,  Y02A90/24 ,  Y02A90/26

    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.

    Abstract translation: 提供了通过向受试者施用有效量的COMT调节剂，ADRB2调节剂，ADRB3调节剂或其组合来治疗体感障碍和调节促炎细胞因子的产生的方法。 进一步提供了通过确定关于选自COMT，ADRB2，ADRB3的基因及其组合的受试者的基因型来预测受体感障碍患者的有效药理学疗法的方法。 通过根据选自以下的基因确定受试者的基因型来确定疼痛反应或疼痛感知和预测受试者发展相关病症如体感障碍和躯体化的易感性的方法，所述基因选自：COMT，ADRB2，ADRB3， 并进一步提供其组合。

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