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公开(公告)号：CN1329663A
公开(公告)日：2002-01-02
申请号：CN99814291.3
申请日：1999-10-06
Applicant: 吉尼西斯研究及发展有限公司 , 弗莱彻·查仁茨·福雷斯特斯有限公司
Inventor： L·N·布洛克斯博格 , I·J·哈乌卡拉
CPC classification number: C12N9/0004 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/93 , C12N15/8255 , C12Y110/03001 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
Abstract: 提供了与木质素生物合成途径相关的新型分离多核苷酸和多肽,以及包括所述序列的结构。还披露了用于在目标生物中改变木质素含量、木质素结构和木质素组成的方法,该方法包括将本发明的一种或多种多核苷酸整合到目标生物的基因组中。
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公开(公告)号：CN103987840A
公开(公告)日：2014-08-13
申请号：CN201280048260.5
申请日：2012-08-07
Inventor： 于尔根·汉森 , 埃斯本·哈尔克耶尔·汉森 , 霍尼·泊卢尔 , 约瑟夫·M·谢里登 , 乔纳森·R·希尔 , 威廉·D.O.·汉密尔顿
CPC classification number: C12P7/24 , A23L33/105 , C07K14/395 , C12N9/0006 , C12N9/1011 , C12N9/88 , C12N15/8221 , C12P19/46 , C12Y101/01025 , C12Y201/01006 , C12Y402/01118
Abstract: 本发明公开了已被工程化改造以单独地或与一种或多种香草醛生物合成酶类或UDP-糖基转移酶（UGT）组合地表达突变体AROM多肽和/或突变体儿茶酚-O-甲基转移酶多肽的重组微生物、植物和植物细胞。这样的微生物、植物或植物细胞可以生产香草醛或香草醛β-D-葡萄糖苷。
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公开(公告)号：CN102203119A
公开(公告)日：2011-09-28
申请号：CN200980138401.0
申请日：2009-09-08
Applicant: 香港大学
CPC classification number: C07K16/44 , C07K7/08 , C07K16/40 , C07K2319/40 , C12N9/1011 , C12Y201/01006 , G01N33/573 , G01N2333/91022 , Y10S435/975
Abstract: 本文公开了定量样品中儿茶酚胺-O-甲基转移酶(COMT)蛋白的量的测定(测定法)，所述样品为例如来自细胞培养物、体液、组织的提取物以及环境样品。其在竞争性ELISA系统中将新型试剂(抗-NE、COMT-NE或COMT-表位-NE)与先前所述的两种试剂(抗-COMT和COMT)联合使用以实现此目的。
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公开(公告)号：CN107519157A
公开(公告)日：2017-12-29
申请号：CN201710570051.1
申请日：2009-09-10
Applicant: 原子能和替代能源委员会 , BM系统
Inventor： 弗兰克·摩松 , M·查芙里特 , 简·菲利普·戴斯里斯 , F·艾瑞斯
IPC: A61K31/136 , A61K31/56 , A61K31/4709 , A61K31/69 , A61K31/553 , A61K31/5415 , A61K31/4458 , A61K31/13 , A61K31/48 , A61K31/4045 , A61K31/473 , A61K31/496 , A61K31/40 , A61K31/166 , A61K31/454 , A61K31/519 , A61K31/451 , A61K31/135 , A61K31/4535 , A61K31/4453 , A61K31/195 , A61K31/55 , A61K31/5375 , A61K31/137 , A61K31/551 , A61K31/4525 , A61K31/165 , A61K31/5513 , A61K31/343 , A61K38/51 , A61K45/06 , A61P25/00 , A61P25/28
CPC classification number: A61K31/196 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/343 , A61K31/4525 , A61K31/551 , A61K31/5513 , A61K31/56 , A61K45/06 , A61K2300/00 , A61K31/136 , A61K31/13 , A61K31/166 , A61K31/195 , A61K31/40 , A61K31/4045 , A61K31/4453 , A61K31/4458 , A61K31/451 , A61K31/4535 , A61K31/454 , A61K31/4709 , A61K31/473 , A61K31/48 , A61K31/496 , A61K31/519 , A61K31/5375 , A61K31/5415 , A61K31/55 , A61K31/553 , A61K31/69 , A61K38/45 , A61K38/51 , C12Y201/01006 , C12Y401/01084
Abstract: 本发明首次涉及一种含有至少一种连接蛋白-阻断剂和一种精神药物的产品，作为复合产品，它可以与其他药物同时、分开或间隔施用于患有精神疾病和/或神经退行性疾病的患者。所述连接蛋白-阻断剂有利地选自包括甲氯芬那酸、18-β-甘草次酸、甘珀酸、甲氟喹和2-APB的组，优选地包含甲氯芬那酸。
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公开(公告)号：CN102203119B
公开(公告)日：2014-11-12
申请号：CN200980138401.0
申请日：2009-09-08
Applicant: 香港大学
CPC classification number: C07K16/44 , C07K7/08 , C07K16/40 , C07K2319/40 , C12N9/1011 , C12Y201/01006 , G01N33/573 , G01N2333/91022 , Y10S435/975
Abstract: 本文公开了定量样品中儿茶酚胺-O-甲基转移酶(COMT)蛋白的量的测定(测定法)，所述样品为例如来自细胞培养物、体液、组织的提取物以及环境样品。其在竞争性ELISA系统中将新型试剂(抗-NE、COMT-NE或COMT-表位-NE)与先前所述的两种试剂(抗-COMT和COMT)联合使用以实现此目的。
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Patent Agency Ranking
公开(公告)号：US20030131373A1
公开(公告)日：2003-07-10
申请号：US10174693
申请日：2002-06-18
Inventor： Leonard N. Bloksberg , Ilkka Havukkala
IPC: A01H005/00 , C12Q001/68 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/04
CPC classification number: C12Y110/03001 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/88 , C12N9/93 , C12N15/8255 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with genetic constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
Abstract translation: 提供了与木质素生物合成途径相关的新型分离的多核苷酸和多肽，以及包括这些序列的遗传构建体。 还公开了调节靶生物体中木质素含量，木质素结构和木质素组成的方法，所述方法包括将一种或多种本发明的多核苷酸掺入目标生物体的基因组中。
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公开(公告)号：US07087426B2
公开(公告)日：2006-08-08
申请号：US10174693
申请日：2002-06-18
Applicant: Leonard N. Bloksberg , Ikka Havukkala
Inventor： Leonard N. Bloksberg , Ikka Havukkala
CPC classification number: C12Y110/03001 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/88 , C12N9/93 , C12N15/8255 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with genetic constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
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公开(公告)号：US06410718B1
公开(公告)日：2002-06-25
申请号：US09615192
申请日：2000-07-12
Applicant: Leonard N. Bloksberg , Ilkka Havukkala
Inventor： Leonard N. Bloksberg , Ilkka Havukkala
IPC: C07H2102
CPC classification number: C12Y110/03001 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2414 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/88 , C12N9/93 , C12N15/8255 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
Abstract translation: 提供了与木质素生物合成途径相关的新型分离的多核苷酸和多肽以及包括这些序列的构建体。 还公开了调节靶生物体中木质素含量，木质素结构和木质素组成的方法，所述方法包括将一种或多种本发明的多核苷酸掺入目标生物体的基因组中。
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9.发明申请COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF VANILLAN OR VANILLIN BETA-D-GLUCOSIDE 审中-公开VANILLAN或VANILLIN BET-D-GLUCOSIDE的生物合成的组合物和方法公开(公告)号：US20140245496A1
公开(公告)日：2014-08-28
申请号：US14236991
申请日：2012-08-07
Applicant: Joergen Hansen , Esben Halkjaer Hansen , Honey Polur , Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton
Inventor： Joergen Hansen , Esben Halkjaer Hansen , Honey Polur , Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton
CPC classification number: C12P7/24 , A23L33/105 , C07K14/395 , C12N9/0006 , C12N9/1011 , C12N9/88 , C12N15/8221 , C12P19/46 , C12Y101/01025 , C12Y201/01006 , C12Y402/01118
Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
Abstract translation: 已经公开了重组微生物，植物和植物细胞，其被单独或与一种或多种香草醛生物合成酶或UDP-糖基转移酶（UGT）组合表达突变型AROM多肽和/或突变型儿茶酚-O-甲基转移酶多肽。 这样的微生物，植物或植物细胞可以产生香草醛或香草醛β-D-葡萄糖苷。
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公开(公告)号：US20060183895A1
公开(公告)日：2006-08-17
申请号：US11397533
申请日：2006-04-03
Applicant: Leonard Bloksberg , Iikka Havukkala
Inventor： Leonard Bloksberg , Iikka Havukkala
IPC: C07H21/04
CPC classification number: C12N9/0004 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/93 , C12N15/8255 , C12Y110/03001 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with genetic constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
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