公开(公告)号：WO1990007107A1

公开(公告)日：1990-06-28

申请号：PCT/DK1989000300

申请日：1989-12-21

Applicant: RADIOMETER A/S ,  LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

Inventor： RADIOMETER A/S

IPC: G01N21/64

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method according to the invention is a method of photometric in vitro determination of the content of oxygen in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container of a sampling device. The sample container has a measuring chamber wherein a luminophor is provided, whereof the luminescence is quenched in the presence of oxygen. The oxygen content is determined on the basis of the radiation detected by the radiation detector. A sampling device and a system for photometric in vitro determination of oxygen in a blood sample is also described.

Abstract translation: 根据本发明的方法是一种光度测定血样中氧含量的方法。 血液样品直接从体内局部转移到采样装置的至少部分透明的样品容器。 样品容器具有测量室，其中提供发光体，在氧的存在下发光被淬灭。 基于由辐射检测器检测的辐射来确定氧含量。 还描述了用于血液样品中氧的光度测定的取样装置和系统。

公开(公告)号：WO1990007106A1

公开(公告)日：1990-06-28

申请号：PCT/DK1989000302

申请日：1989-12-21

Applicant: RADIOMETER A/S ,  LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

Inventor： RADIOMETER A/S

IPC: G01N21/11

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method is a method of photometric in vitro determination of a blood gas parameter in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container, whereafter the connection between the sample containing sample container and the blood circulation is broken. Subsequently the sample container with its content of blood sample is brought into optical communication with an optical system comprising a radiation source and a radiation detector interacting therewith, preferably by placing the sample container in a sample container system in an analyzer. The blood gas parameter is determined on the basis of the radiation detected by the radiation detector. A system for photometric in vitro determination of a blood gas parameter in a blood sample is also described.

公开(公告)号：EP0695937B1

公开(公告)日：2002-05-29

申请号：EP95115523.3

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： Lundsgaard, Finn Chresten ,  Jensen, Niels-Henrik ,  Andersen, Willy

IPC: G01N21/64 ,  G01N21/11 ,  G01N33/487

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

公开(公告)号：EP0354895B1

公开(公告)日：1995-09-27

申请号：EP89890203.6

申请日：1989-07-31

Applicant: AVL Medical Instruments AG

Inventor： Leiner, Marco Jean-Pierre, Dr. ,  Harnoncourt, Karl, Dr. ,  Kirchmayer, Gerald, Dipl.-Ing. ,  Kleinhappl, Erich ,  List, Helmut, Dipl.-Ing. ,  Marsoner, Hermann, Dipl.-Ing. Dr. ,  Wolfbeis, Otto S., Dr. ,  Ziegler, Werner E., Dipl.-Ing.

IPC: A61B5/14 ,  G01N1/10 ,  G01N33/48 ,  G01N21/17

CPC classification number: G01N1/28 ,  G01N21/7703 ,  G01N33/487 ,  G01N2201/1288

公开(公告)号：EP0449899A1

公开(公告)日：1991-10-09

申请号：EP90900765.0

申请日：1989-12-21

Applicant: RADIOMETER A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N33 ,  G01N21 ,  G01N35

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: On fait passer l'échantillon de sang d'un emplacement in vivo directement dans le récipient d'échantillons au moins partiellement transparent d'un dispositif de prélèvement d'échantillons. Ce récipient d'échantillons comporte une chambre de mesure dans laquelle se trouve un luminophore dont la luminescence est étouffée en présence d'oxygène. On détermine la teneur en oxygène sur la base de la radiation mesurée par un détecteur de radiation. Sont également décrits un dispositif de prélèvement d'échantillons et un système de détermination photométrique in vitro de l'oxygène dans un échantillon de sang.

公开(公告)号：EP0695937A1

公开(公告)日：1996-02-07

申请号：EP95115523.3

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： Lundsgaard, Finn Chresten ,  Jensen, Niels-Henrik ,  Andersen, Willy

IPC: G01N21/64 ,  G01N21/11 ,  G01N33/487

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method is a method of photometric in vitro determination of a blood gas parameter in a blood sample. The blood gas parameter is oxygen. The method comprises transferring the blood sample to a sample container with a transparent wall portion and with an inlet opening and otherwise being essentially sealed, said sample container incorporating a luminophor whose luminescence is quenched in the presence of oxygen, disposing the sample container in optical communication with an optical system comprising a radiation source and a radiation detector, transmitting radiation from the radiation source to the sample container to excite the luminophor, transmitting the luminescence emitted by the excited luminophor to the radiation detector, and detecting and registering the luminescence.
A sample container and a system for photometric in vitro determination of oxygen in a blood sample is also described.

Abstract translation: 该方法是血液样品中血气参数的光度测定方法。 血气参数为氧气。 该方法包括将血液样品转移到具有透明壁部分和入口开口的样品容器中，否则基本上密封，所述样品容器包含发光体，发光体在氧气存在下被淬火，将样品容器设置在光学通信 使用包括辐射源和辐射检测器的光学系统，将来自辐射源的辐射传输到样品容器以激发发光体，将由激发的发光体发射的发光传输到辐射检测器，以及检测和记录发光。 还描述了样品容器和用于光学体外测定血液样品中的氧的系统。 $$

公开(公告)号：EP0534945B1

公开(公告)日：1994-09-14

申请号：EP90900767.6

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N21/77 ,  G01N33/48

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method is a method of photometric in vitro determination of the content of an analyte in a sample of whole blood. The blood sample is transferred from an in vivo locality directly to the sample container of a sampling device. The sample container comprises a measuring chamber wherein there is provided a transparent body the radiation transmission characteristics of which vary with the content of analyte in the environment of the body. The transparent body is equilibrated with the sample and thereafter the measuring chamber is deformed in a controlled manner while the portion of the measuring chamber located in the radiation transmission path is drained for blood sample. The analyte content is determined on the basis of detection of the radiation transmitted from the radiation source through the deformed measuring chamber and the transparent body and to the radiation detector. A sampling device and an analyzer for use in photometric in vitro determination of the content of an analyte in a blood sample is also described.

公开(公告)号：EP0534945A1

公开(公告)日：1993-04-07

申请号：EP90900767.0

申请日：1989-12-21

Applicant: RADIOMETER A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N33 ,  G01N21 ,  G01N35

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: On fait passer l'échantillon de sang directement d'un emplacement in vivo au récipient d'échantillon d'un dispositif de prélèvement d'échantillons. Le récipient d'échantilons comprend une chambre de mesure contenant un corps transparent dont les caractéristiques de transmission de radiation varient en fonction de la teneur en analyte de l'environnement du corps. On établit un équilibre chimique entre le corps transparent et l'échantillon et on déforme ensuite la chambre de mesure d'une manière commandée, l'échantillon de sang étant alors évacué de la portion de la chambre de mesure située sur la trajectoire de transmission de radiation. On détermine la teneur en analyte sur la base de la valeur de la radiation transmise par la source de radiation au détecteur de radiation à travers la chambre de mesure déformée et le corps transparent. Sont également décrits un dispositif de prélèvement d'échantillon et un analyseur utilisés pour la détermination photométrique in vitro de la teneur en analyte d'un échantillon de sang.

公开(公告)号：EP0449900B1

公开(公告)日：1996-04-10

申请号：EP90900766.8

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N21/11 ,  G01N33/49

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method is a method of photometric in vitro determination of a blood gas parameter in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container, whereafter the connection between the sample containing sample container and the blood circulation is broken. Subsequently the sample container with its content of blood sample is brought into optical communication with an optical system comprising a radiation source and a radiation detector interacting therewith, preferably by placing the sample container in a sample container system in an analyzer. The blood gas parameter is determined on the basis of the radiation detected by the radiation detector. A system for photometric in vitro determination of a blood gas parameter in a blood sample is also described.

公开(公告)号：EP0449899B1

公开(公告)日：1994-09-28

申请号：EP90900765.0

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N21/64 ,  G01N33/48

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method according to the invention is a method of photometric in vitro determination of the content of oxygen in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container of a sampling device. The sample container has a measuring chamber wherein a luminophor is provided, whereof the luminescence is quenched in the presence of oxygen. The oxygen content is determined on the basis of the radiation detected by the radiation detector. A sampling device and a system for photometric in vitro determination of oxygen in a blood sample is also described.