Patent search cpc:"H01J49/044" Page 2

11.

发明公开
离子分析装置无效

公开(公告)号：CN108475615A

公开(公告)日：2018-08-31

申请号：CN201580085406.7

申请日：2015-12-17

Applicant: 株式会社岛津制作所

Inventor： 福井航

IPC: H01J49/24 , H01J49/10

CPC classification number: H01J49/167 , H01J49/0404 , H01J49/044 , H01J49/049 , H01J49/0495 , H01J49/063 , H01J49/14 , H01J49/24 , H01J49/26

Abstract: 一种离子分析装置的特征在于，具备：离子化室(10)，其维持为大气压；分析室(11)，其对在所述离子化室(10)中生成的离子进行分析；真空泵(15、16)，其对所述分析室(11)的内部进行排气；毛细管(102)，其将所述离子化室(10)与所述分析室(11)连通；流导变更单元(103、104)，其变更所述毛细管(102)的流导；以及控制部(20)，其在所述分析室(11)的真空度低于预先决定的真空度时，使所述流导变更单元(103、104)进行动作以减小所述毛细管(102)的流导。

12.

发明授权
大气压电离质谱仪有权

公开(公告)号：CN102971826B

公开(公告)日：2015-07-22

申请号：CN201080067689.X

申请日：2010-06-24

Applicant: 株式会社岛津制作所

Inventor： 向畑和男 , 奥村大辅

IPC: H01J49/06 , G01N27/62

CPC classification number: H01J49/42 , H01J49/044 , H01J49/067 , H01J49/34

Abstract: 在第一级中间真空室(6)内，成为背景噪声的原因的簇离子主要在区域(A)生成，碎片离子主要在区域(B)生成。因此，在源内CID分析模式下，对第一离子导向器(7)施加比分离器(8)低的直流电压，使得在区域(B)生成加速电场。由此，能够对离子赋予足够的能量来促进碎片化。在不进行源内CID的情况下，对脱溶剂管(3)的出口端(3b)施加比第一离子导向器(7)低的直流电压，使得在区域(B)不产生电场而只在区域(A)生成加速电场。由此，能够同时抑制簇离子和碎片离子的生成，取得质量高的色谱。

13.

发明公开
MASS SPECTROMETRY USING LASERSPRAY IONIZATION 审中-公开
Title translation: MASS激光使用喷雾电离

公开(公告)号：EP2438605A1

公开(公告)日：2012-04-11

申请号：EP10784123.1

申请日：2010-06-03

Applicant: WAYNE STATE UNIVERSITY

Inventor： TRIMPIN, Sarah

IPC: H01J27/24

CPC classification number: H01J49/044 , H01J27/24 , H01J49/0468 , H01J49/164

Abstract: Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging.

14.

发明授权
ATMOSPHERIC PRESSURE CHARGED PARTICLE DISCRIMINATOR FOR MASS SPECTROMETRY 有权
Title translation: 常压DISCRIMINATOR为MASS带电粒子

公开(公告)号：EP1593144B1

公开(公告)日：2009-11-25

申请号：EP04775770.3

申请日：2004-02-13

Applicant: MDS Sciex

Inventor： SCHNEIDER, Bradley , COVEY, Thomas, R

IPC: H01J49/04

CPC classification number: H01J49/06 , H01J49/044

15.

发明公开
DEVICE AND METHOD FOR PREVENTING ION SOURCE GASES FROM ENTERING REACTION/COLLISION CELLS IN MASS SPECTROMETRY 审中-公开
Title translation: 方法和质量设备，以防止渗透气体从离子源中的KOLLISONSZELLE

公开(公告)号：EP1314187A2

公开(公告)日：2003-05-28

申请号：EP01969098.1

申请日：2001-08-24

Applicant: MDS Inc., doing business as MDS Sciex

Inventor： TANNER, Scott, D. , BANDURA, Dmitry, R. , BARANOV, Vladimir, I.

IPC: H01J49/04

CPC classification number: H01J49/061 , H01J49/044

Abstract: A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An inn-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

16.

发明授权
ION SPRAY WITH INTERSECTING FLOW 失效
Title translation: 芳基取代的5,5-稠合芳族氮化合物AGENTS抗炎

公开(公告)号：EP0739533B1

公开(公告)日：1999-04-28

申请号：EP95905498.2

申请日：1995-01-09

Applicant: MDS Inc.

Inventor： COVEY, Thomas, R. , ANACLETO, Joseph, F.

IPC: H01J49/04 , G01N30/72

CPC classification number: H01J49/165 , G01N30/7246 , H01J49/044 , H01J49/0477

Abstract: Liquid from a liquid chromatograph or other sample source, preferably assisted by a high velocity coaxial gas jet, is sprayed through a capillary tube (40') producing a flow in a first direction of charged droplets (50'). A flow of heated gas (60), in a second direction different from the first direction, intersects the droplet flow at a region (64) upstream of an orifice (20'). The flows mix turbulently, with the second flow helping to evaporate the droplets to produce ions and helping to move the evaporating droplets toward the orifice (20'), providing a focusing effect. Ions are drawn through the orifice (20') into a mass analyzer and analyzed. Alternatively the flows of liquid and heating gas can be directed toward each other and at right angles to the axis through the orifice, and the inhaling effect of the orifice can be used to draw droplets toward it, or a third gas flow can be used for this purpose. The heated intersecting gas flow typically provides an increase in sensitivity (ion counts per second) of between 10 and 100 times. Heating the droplet plume also allows controlled desaturation of ions and an increase in the number of charges on them, without degrading the ions.

17.

发明公开
ELECTROSPRAY ION SOURCE FOR MASS SPECTROMETRY 失效
Title translation: 电子离子源用于大量光谱

公开(公告)号：EP0511961A4

公开(公告)日：1993-01-27

申请号：EP90916167

申请日：1990-09-19

Applicant: THE ROCKEFELLER UNIVERSITY

Inventor： CHAIT, BRIAN, T. , KATTA, VISWANATHAM , CHOWDHURY, SWAPAN, K.

IPC: H01J49/04 , H01J49/10

CPC classification number: H01J49/0404 , H01J49/044 , H01J49/0468 , H01J49/165

Abstract: An electrospray ion source is designated for ready and simple plugging into commercial mass analyzers for mass spectrometric analysis of organic molecules. The electrospray is carried out in the ambient air (14) and the ions and other charged species enter the mass analzyer (31) through a long metal capillary tube (11) and three stages of differential pumping. The use of the long tube (11) allows (a) convenient injection of the ions into the mass analyzer (31); (b) optimization of the spray by direct visualization in the air (11-14); (c) efficient and controlled heat transfer to the droplets; and (d) efficient pumping of the region (32) between the capillary exit and the skimmer (28). Desolvation of the solvated ions is carried out using a combination of controlled heat transfer to the charged droplets during the transit through the tube (11) and collisional activation in a region of reduced pressure (32). Desolvation with this system does not involve use of a strong countercurrent flow of heated gas. The system may also be used to obtain the collisional activated fragmentation spectra of molecule ions. The use of a metal capillary tube (11) avoids complications from charging that arise from the use of dielectric capillary tubes.

18.

发明公开
Method and apparatus for the mass spectrometric analysis of solutions 失效
Title translation: 为解决方案的质谱分析方法和设备。

公开(公告)号：EP0123552A1

公开(公告)日：1984-10-31

申请号：EP84302751.7

申请日：1984-04-24

Applicant: YALE UNIVERSITY

Inventor： Labowsky, Michael J. , Fenn, John B. , Yamashita, Masamichi

IPC: H01J49/00 , B01D59/44

CPC classification number: H01J49/165 , B01D59/44 , G01N30/7273 , G01N30/7293 , H01J49/044 , H01J49/0477 , G01N2030/3007

Abstract: An electrospray ion source for a mass spectrometer capable of generating ions from samples dissolved in a solution comprises a capillary tube (30) through which the said solution is pumped into a first chamber maintained substantially at atmospheric pressure and in which an inert gas, preferably heated, is flowing in a direction counter to the flow of the solution, and a small orifice (4) in the end wall (1) of the chamber opposite to and aligned with the capillary. A high potential difference is applied between the capillary tube (30) and the end wall (1) so thatthe solution is electrosprayed into the chamber and ions characteristic of the sample are formed. These ions are desolvated to a controllable extent by the inert gas, which is usually heated to improve the efficiency of the process and increase the maximum permissible flow rate of solution. The ions so formed pass through the small orifice (4) into a second chamber maintained at a reduced pressure, and into a mass spectrometer (29). Alternatively an additional pressure reduction stage can be included, so that the ions pass into a third chamber maintained at a still lower pressure in which the mass spectrometer (29) is situated through a hole (23) in skimmer (24). The ion source is particularly effective for the production of unfragmented and unsolvated ions from thermally unstable or involatile samples, and may be used as a liquid chromatograph - mass spectrometer interface.

19.

发明公开
SEALING INTERFACE FOR CURTAIN CHAMBER 审中-公开

公开(公告)号：US20240222104A1

公开(公告)日：2024-07-04

申请号：US18684195

申请日：2022-08-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Stanislaw POTYRALA , Bradley B. SCHNEIDER , Leigh BEDFORD

IPC: H01J49/04 , H01J49/06 , H01J49/16

CPC classification number: H01J49/044 , H01J49/045 , H01J49/067 , H01J49/165

Abstract: A curtain chamber includes an orifice plate defining an orifice plate bore. A curtain plate is disposed adjacent to the orifice plate and defines a curtain plate bore. The orifice plate bore is disposed adjacent the curtain plate bore. A biasing element includes a first portion disposed in the orifice plate bore and a second portion disposed in the curtain plate bore. The biasing element biases the curtain plate towards the orifice plate. A race is defined by at least one of the orifice plate and the curtain plate. The race defines a race depth. A seal is disposed in the race. The seal includes an uncompressed seal depth greater than the race depth and a compressed seal depth less than the uncompressed seal depth.