公开(公告)号：WO2021203041A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/025637

申请日：2021-04-02

Applicant: WAYNE STATE UNIVERSITY

Inventor： AUNER, Gregory William ,  BRUSATORI, Michelle Ann ,  SHANLEY, Charles James ,  KOYA, Satya Kiran

IPC: G01N21/65 ,  C12Q1/18 ,  G01J2003/1861 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/1838 ,  G01J3/44 ,  G01N2021/651 ,  G01N2333/11 ,  G01N2333/165 ,  G01N33/56983

Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a Raman spectroscopic system for determining antimicrobial resistance of a pathogen in a sample is provided. The Raman spectroscopic system may include a cuvette configured to receive the sample, an excitation light source configured to radiate a light beam into the cuvette through a bottom end of the cuvette and onto a portion of the sample contained in the cuvette, and at least one optical element configured to direct a Raman signal from the portion of the sample passing through the bottom end of the cuvette to a Raman spectrometer. The Raman spectroscopic system is configured to detect resistance or susceptibility of the pathogen to at least one antimicrobial agent based on the Raman signal.

公开(公告)号：WO2021196622A1

公开(公告)日：2021-10-07

申请号：PCT/CN2020/127732

申请日：2020-11-10

Applicant: HONG KONG APPLIED SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE COMPANY LIMITED

Inventor： MAI, Jiangquan

IPC: G01J3/12 ,  G01J2003/4538 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0256 ,  G01J3/4531 ,  G02B19/0014 ,  G02B19/0085 ,  G02B5/3083

Abstract: Systems and methods which provide a high-throughput point source light coupling structure (120) implementing a condenser (122) configured according to one or more condenser (122) configuration rules are described. Embodiments of a high-throughput point source light coupling structure (120) utilize a birefringent plate (341, 342) configuration in combination with a condenser (122) and point source (121) to provide a light coupler structure (120) for a birefringent-static-Fourier transform interferometer implementation. According to some examples, the optical axis of a first and second birefringent plate (341, 342) of a birefringent plate (341, 342) configuration are not in the same plane. The condenser (122) of the high-throughput point source light coupling structure (120) of embodiments is provided in a defined (e.g., spaced, relational, etc.) relationship with respect to the point source (121) and/or a camera lens (131) used in capturing an interference pattern generated by the light coupling structure (120). The high-throughput point source light coupling structure (120) herein may be provided as external accessories for processor-based mobile devices (130) having image capturing capabilities.

公开(公告)号：WO2021123262A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/087162

申请日：2020-12-18

Applicant: UNIVERSITÄT POTSDAM

Inventor： POLLEY, Nabarun ,  HASS, Roland ,  REICH, Oliver

IPC: G01J3/02 ,  G01N21/49 ,  G01J3/44 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/4412

Abstract: The invention relates to a measuring arrangement for an optical spectrometer, in particular a photon density wave (PDW) spectrometer. The measuring arrangement comprises a plurality of optical waveguide elements (20), each of which extending along a longitudinal direction (24) from a proximal end (22) to a distal end (23), the distal end (23) configured to be placed in a substance to be measured. The optical waveguide elements (20) are configured for receiving excitation light from a light emitting device at the proximal end (22) and for emitting the excitation light into a substance to be measured at an outlet (21) at the distal end (23). They may further be configured for receiving measurement light caused by excitation light emitted into the substance and for conducting the measurement light towards the proximal end (22) to a detection device. The outlet (21) of the optical waveguide elements (20) are formed laterally relative to the longitudinal direction (24) such that excitation light is emitted from the outlet (21) in an emitting direction (25) transverse to the longitudinal direction (24) and/or measurement light is received in a receiving direction (25) transverse to the longitudi- nal direction (24). The outlets (21) may be arranged in at least two groups to form at least two sensing zones for measuring a substance in at least two distinct measuring spaces around the sensing zones.