METHOD OF DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE OF A BODILY FLUID, MOBILE DEVICE, KIT, COMUTER PROGRAM AND COMPUTER-READABLE STORAGE MEDIUM

    公开(公告)号:WO2021249895A1

    公开(公告)日:2021-12-16

    申请号:PCT/EP2021/065087

    申请日:2021-06-07

    Abstract: A method of determining the concentration of at least one analyte in a sample of a bodily fluid by using a mobile device (112) having at least one camera (120), the method comprising: i) capturing, by using the camera (120), at least one image of at least a part of a color reference card (118) and of at least a part of at least one reagent test field (116) of at least one optical test strip (114) having the sample applied thereto, - wherein, in the image, the test field (116) is in a defined position with respect to the color reference card (118), - wherein the color reference card (118) comprises a plurality of different gray reference fields (126) locally assigned to the test field (116), wherein the plurality of gray reference fields (126) and the test field (116) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the test field (116) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the test field (116), and - wherein the color reference card (118) comprises a plurality of different color reference fields (128) having known reference color values and a plurality of different gray reference fields (126) locally assigned to the color reference fields (128), wherein the plurality of gray reference fields (126) and the color reference fields (128) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the color reference fields (128) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the color reference fields (128), ii) applying at least one predetermined pixel-based mean tone map correction to the image obtained in step i), thereby obtaining at least one first intensity-corrected image, wherein the predetermined pixel-based mean tone map correction comprises an assignment of a second brightness value to a first brightness value, wherein the first brightness value is recorded by the camera (120), wherein each pixel of the recorded image is corrected individually by the predetermined A method of determining the concentration of at least one analyte in a sample of a bodily fluid by using a mobile device (112) having at least one camera (120), the method comprising: i) capturing, by using the camera (120), at least one image of at least a part of a color reference card (118) and of at least a part of at least one reagent test field (116) of at least one optical test strip (114) having the sample applied thereto, - wherein, in the image, the test field (116) is in a defined position with respect to the color reference card (118), - wherein the color reference card (118) comprises a plurality of different gray reference fields (126) locally assigned to the test field (116), wherein the plurality of gray reference fields (126) and the test field (116) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the test field (116) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the test field (116), and - wherein the color reference card (118) comprises a plurality of different color reference fields (128) having known reference color values and a plurality of different gray reference fields (126) locally assigned to the color reference fields (128), wherein the plurality of gray reference fields (126) and the color reference fields (128) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the color reference fields (128) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the color reference fields (128), ii) applying at least one predetermined pixel-based mean tone map correction to the image obtained in step i), thereby obtaining at least one first intensity-corrected image, wherein the predetermined pixel-based mean tone map correction comprises an assignment of a second brightness value to a first brightness value, wherein the first brightness value is recorded by the camera (120), wherein each pixel of the recorded image is corrected individually by the predetermined pixel- based mean tone map correction, wherein the mean tone map correction is derived by combining a plurality of tone map corrections for different types of mobile devices; iii) deriving, from the first intensity-corrected image, local brightness information (174) for at least some of the color reference fields (128) and for the test field (116), by using the gray reference fields (126) locally assigned to the color reference fields (128) and the test field (116), respectively, wherein the local brightness information (174) comprises a numerical indication describing the local intensity of at least one RGB color of the color reference fields (128) and the test field (116), respectively; iv) applying at least one mobile device-specific tone map correction to the first intensity-corrected image, the mobile device-specific tone map correction taking into account the local brightness information (174), thereby obtaining at least one second intensity-corrected image; and v) determining the analyte concentration based on a color formation reaction of the test field (116) by using the second intensity-corrected image.

    SYSTEM AND METHOD FOR PERFORMING LASER-INDUCED BREAKDOWN SPECTROSCOPY MEASUREMENTS ON MOLTEN METAL SAMPLES

    公开(公告)号:WO2023037392A2

    公开(公告)日:2023-03-16

    申请号:PCT/IS2022/050007

    申请日:2022-09-07

    Applicant: DTE EHF.

    Abstract: LIBS measurement systems are disclosed that are configured to monitor a temperature of a molten metal sample (10) during cooling of the molten metal sample in a crucible (20), and to initiate a LIBS measurement after the temperature of the molten metal sample satisfies measurement temperature criteria. The system may also monitor the temperature of an empty crucible to assist in ensuring that the crucible temperature is (i) sufficiently high to ensure that after the molten metal sample is delivered to the crucible and cools to satisfy the measurement temperature criteria, a sufficiently low cooling rate of the molten metal sample occurs during the LIBS measurement, and (ii) optionally sufficiently low to avoid an unnecessarily long cooling time of the molten metal sample prior to satisfying the measurement temperature criteria and initiation of the LIBS measurement. The LIBS measurement system may be mobile and battery-powered, and may include an integrated calibration station (500).

    WAVEGUIDE SENSOR WINDOW OPENING
    17.
    发明申请

    公开(公告)号:WO2022238204A1

    公开(公告)日:2022-11-17

    申请号:PCT/EP2022/061999

    申请日:2022-05-04

    Applicant: AMS AG

    Abstract: A method for manufacturing a sensor (10) is provided, the method comprising the steps of providing a lower cladding layer (11), depositing a waveguide layer (12) on the lower cladding layer (11), forming a sensing waveguide (13) and a reference waveguide (14) by photolithography and etching the waveguide layer (12) in places, forming a photoresist structure (15) on at least a part of the sensing waveguide (13) by photolithography, depositing an upper cladding layer (16) on the photoresist structure (15), the sensing waveguide (13), the reference waveguide (14) and the lower cladding layer (11), removing the photoresist structure (15) with the part of the upper cladding layer (16) deposited on the photoresist structure (15) so that an opening (17) within the upper cladding layer (16) is formed above at least a part of the sensing waveguide (13), and depositing a functionalization material (18) within the opening (17), wherein from the waveguide layer (12) at least one auxiliary structure (22) is formed by photolithography and etching the waveguide layer (12) in places, wherein the opening (17) is arranged above the auxiliary structure (22). Furthermore, a sensor (10) and a portable device (26) are provided.

    CALIBRATION FOR AN INTERFEROMETER
    18.
    发明申请

    公开(公告)号:WO2022238170A1

    公开(公告)日:2022-11-17

    申请号:PCT/EP2022/061773

    申请日:2022-05-03

    Inventor: MEUNIER, Nicolas

    Abstract: There is described a system comprising: one or more micro Mach-Zehnder Interferometers or MZIs, with receptors (e.g. peptides) to compounds placed in sensing arms of said MZIs, said Mach-Zehnder Interferometers being based on one or more Multi-Mode Interference couplers or MMIs; and a processor configured to : receive data signals from said MMI-based MZI, said data signals comprising at least k sinusoids diphase of 2π/k; expressing said sinusoids in non- centered ellipses; calibrate said sinusoids by centering and circularizing said non-centered ellipses; and determine the angular phase from said centered and circularized ellipses. Described developments comprise the determination of one or more sensorgrams representing interaction kinetics of adsorption and desorption of target compounds with receptors placed in optical paths of the MMI based – MZIs; the determination of one or more signatures associated with one or more odors; the use of diverse MMI types; embodiments wherein sensors are placed in a smartwatch.

    OPTICAL MODULE
    19.
    发明申请
    OPTICAL MODULE 审中-公开

    公开(公告)号:WO2022207713A1

    公开(公告)日:2022-10-06

    申请号:PCT/EP2022/058429

    申请日:2022-03-30

    Abstract: An optical module (200) for Raman spectroscopy. The optical module comprises: a laser source (201) mounted on a substrate (202) and configured to emit electromagnetic radiation (203) at a target (204); a plurality of sensors (206) mounted on the substrate (202) and configured to detect electromagnetic radiation (207) scattered from the target (204); and a first filter (208) disposed over one or more of the plurality of sensors (206), wherein the first filter (208) is substantially transparent to a first wavelength band corresponding to a Raman scattering wavelength of a first molecule of the target (204) and opaque to wavelengths outside the first wavelength band.

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