公开(公告)号：WO2015010185A1

公开(公告)日：2015-01-29

申请号：PCT/CA2014/000582

申请日：2014-07-25

Applicant: UNIVERSITY OF SASKATCHEWAN ,  WHITE, Aaron P. ,  PERERA, Sumundu R. ,  LAM, Shirley ,  GIBSON, Deanna L.

Inventor： WHITE, Aaron P. ,  PERERA, Sumundu R. ,  LAM, Shirley ,  GIBSON, Deanna L.

IPC: C12N15/31 ,  A61K39/112 ,  A61K39/395 ,  A61P31/04 ,  A61P37/04 ,  C12N15/54 ,  C12N15/61 ,  C12N15/63 ,  C12P19/04 ,  G01N33/564

CPC classification number: A61K39/0275 ,  A61K39/40 ,  C07K16/1235 ,  C12P19/04 ,  G01N33/56916 ,  G01N33/6854 ,  G01N2333/255 ,  G01N2469/20 ,  Y02A50/482

Abstract: Methods of purifying O-Ag capsules from an S. enterica NTS serovar, wherein the O- Ag capsule is substantially free of co-expressed cellulose and LPS, are described, as are immunogenic compositions comprising the O-Ag capsules and methods for treating, preventing and diagnosing Salmonella infections. Also described are constructs and methods for producing S. enterica NTS serovar mutants which over-express the O-Ag capsule.

Abstract translation: 描述了从肠球菌NTS血清型中提取O-Ag胶囊的方法，其中O-Ag胶囊基本上不含共表达的纤维素和LPS，以及包含O-Ag胶囊的免疫原性组合物和用于治疗， 预防和诊断沙门氏菌感染。 还描述了用于产生过表达O-Ag胶囊的肠杆菌NTS血清型突变体的构建体和方法。

公开(公告)号：WO2014179883A1

公开(公告)日：2014-11-13

申请号：PCT/CA2014/050432

申请日：2014-05-06

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： GOKARAJU, Ramakrishna ,  SHRESTHA, Binod ,  SHARMA, Parikshit

IPC: G01R29/00 ,  G01R31/00 ,  H02J13/00

CPC classification number: G01R31/40 ,  G01L1/00 ,  G01R21/00 ,  G01R25/00 ,  H02H7/065 ,  H02P9/102

Abstract: This application describes a state deviation technique for identifying transient instabilities in power systems. Such instabilities may result from disturbances such as external faults and power swing conditions. Detection of transient instabilities is based on the direction of change of phase angle of a machine such as a generator at an equilibrium point. Method and apparatus as disclosed may also be used for assessing system-wide transient stability of a power system or portion thereof.

Abstract translation: 该应用描述了用于识别电力系统中的瞬态不稳定性的状态偏差技术。 这种不稳定性可能是由外部故障和功率摆动条件等干扰引起的。 瞬态不稳定性的检测是基于平衡点等发电机等机械相位角的变化方向。 所公开的方法和装置也可用于评估电力系统或其部分的全系统瞬态稳定性。

公开(公告)号：WO2014121366A1

公开(公告)日：2014-08-14

申请号：PCT/CA2013/000091

申请日：2013-02-05

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： VUJANOVIC, Vladimir ,  GERMIDA, James J.

IPC: C12N1/20 ,  A01H17/00 ,  A01H5/10 ,  A01N63/02 ,  A01N63/04 ,  A01P21/00 ,  A01P3/00 ,  B09C1/10 ,  C12N1/14 ,  C12N15/00

CPC classification number: A01N63/04 ,  A01H17/00 ,  A01N63/00 ,  A01N63/02 ,  B09C1/105 ,  C12R1/465 ,  C12R1/645 ,  C12R1/80 ,  A01N25/00

Abstract: The present disclosure provides novel endophyte strains or cultures thereof that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.

Abstract translation: 本公开提供与植物具有共生关系的新颖的内生真菌菌株或其培养物。 本公开进一步提供了在胁迫和不受胁迫的环境条件下改善种子活力，生物和非生物胁迫抗性，植物健康和产量的方法，包括用新颖的内生真菌菌株接种种子并从中培养植物。

公开(公告)号：WO2011161547A2

公开(公告)日：2011-12-29

申请号：PCT/IB2011/002145

申请日：2011-06-22

Applicant: VENMAR, CES INC. ,  UNIVERSITY OF SASKATCHEWAN ,  ERB, Blake ,  BESANT, Robert, W. ,  SIMONSON, Carey, J. ,  HEMINGSON, Howard

Inventor： ERB, Blake ,  BESANT, Robert, W. ,  SIMONSON, Carey, J. ,  HEMINGSON, Howard

CPC classification number: F24F3/147 ,  F24F3/1417 ,  F24F12/001 ,  F24F12/002 ,  F24F12/006 ,  F24F2001/0092 ,  F24F2003/1435 ,  F28D15/00 ,  F28D21/0015 ,  Y02B30/545 ,  Y02B30/563

Abstract: An energy exchanger is provided. The exchanger includes a housing having a front and a back. A plurality of panels forming desiccant channels extend from the front to the back of the housing. Air channels are formed between adjacent panels. The air channels are configured to direct an air stream in a direction from the front of the housing to the back of the housing. A desiccant inlet is provided in flow communication with the desiccant channels. A desiccant outlet is provided in flow communication with the desiccant channels. The desiccant channels are configured to channel desiccant from the desiccant inlet to the desiccant outlet in at least one of a counter-flow or cross-flow direction with respect to the direction of the air stream.

Abstract translation: 提供换能器。 交换器包括具有正面和背面的壳体。 形成干燥剂通道的多个面板从壳体的前部延伸到后部。 在相邻面板之间形成空气通道。 空气通道构造成沿着从壳体的前部到壳体的后部的方向引导空气流。 提供与干燥剂通道流通的干燥剂入口。 提供与干燥剂通道流通的干燥剂出口。 干燥剂通道构造成将干燥剂从干燥剂入口通道到相对于空气流的方向的逆流或横流方向中的至少一个中的干燥剂出口。

公开(公告)号：WO2011116456A1

公开(公告)日：2011-09-29

申请号：PCT/CA2011/000264

申请日：2011-03-08

Applicant: UNIVERSITY OF SASKATCHEWAN ,  HILL, Janet Elizabeth ,  CHABAN, Bonnie Laura

Inventor： HILL, Janet Elizabeth ,  CHABAN, Bonnie Laura

IPC: C07H21/04 ,  C07H21/00 ,  C12P19/34 ,  C12Q1/02 ,  C12Q1/68 ,  C07K14/195 ,  C12N15/31

CPC classification number: C12Q1/689 ,  C12N15/11 ,  C12Q2600/16

Abstract: The present invention relates to primers for the universal amplification and detection of Archaea, which primers are designed based on a multiple sequence alignment of Archaea Type II chaperonin (thermosome) genes. For detection of Archaea having templates with a GC content of below 60%, primers are designed so that inosine residues are found at degenerate positions. For amplification of higher GC content templates, degenerate positions are replaced with specific nucleotide bases found in the high GC organism. The primers are useful for detecting, identifying and quantifying Archaea in a sample and for determining a phylogenetic relationship of a test Archaea organism.

Abstract translation: 本发明涉及用于通用扩增和检测古菌的引物，该引物是基于古细菌II型伴侣蛋白（热酵母）基因的多重序列比对而设计的。 为了检测具有GC含量低于60％的模板的古菌，设计引物以使得在退化位置发现肌苷残基。 为了扩增较高的GC含量模板，简并位置被高GC生物体中发现的特定核苷酸碱基所替代。 引物可用于检测，鉴定和定量样品中的古菌，并用于确定测试古菌有机体的系统发育关系。

公开(公告)号：WO2009079792A1

公开(公告)日：2009-07-02

申请号：PCT/CA2008/002272

申请日：2008-12-22

Applicant: UNIVERSITY OF SASKATCHEWAN ,  REANEY, Martin J. ,  JIA, Yunhua ,  SHEN, Jianheng ,  SCHOCK, Cynthia ,  TYLER, Nancy ,  ELDER, Jim ,  SINGH, Sarabjeet

Inventor： REANEY, Martin J. ,  JIA, Yunhua ,  SHEN, Jianheng ,  SCHOCK, Cynthia ,  TYLER, Nancy ,  ELDER, Jim ,  SINGH, Sarabjeet

IPC: C07K7/64 ,  A61K36/55 ,  A61K38/12 ,  C07K1/14 ,  C07K7/50 ,  C11B1/10 ,  C11B3/00 ,  A23D9/00

CPC classification number: A61K36/55 ,  A23D9/00 ,  A23D9/007 ,  A61K38/00 ,  C07K1/145 ,  C07K1/16 ,  C07K1/20 ,  C07K7/64 ,  C11B1/06 ,  C11B1/102 ,  C11B3/006 ,  C11B3/10

Abstract: Methods for separation and recovery of individual cyclic peptides from plant materials, said method comprising the steps of: (a) extracting an oil from a plant material; (b) separating the extracted oil into a non-polar fraction and a polar fraction; (c) separation and recovery of cyclic peptides from the non-polar fraction, and (d) separation and recovery of cyclic peptides from the polar fraction. The methods are suitable for separation and recovery of individual cyclolinopeptides from flax seed oil. Individual cyclolinopeptides are useful for modulation physiological disorders associated with apoptosis. Modified flaxseed oils may be produced by commingling flaxseed oils absent cyclolinopeptides, with at least one cyclolinopeptide separated and recovered with the methods disclosed herein.

Abstract translation: 用于从植物材料分离和回收单个环肽的方法，所述方法包括以下步骤：（a）从植物材料中提取油; （b）将提取的油分离成非极性馏分和极性馏分; （c）从非极性级分分离和回收环肽，和（d）从极性级分分离和回收环肽。 该方法适用于从亚麻籽油中分离和回收单个环亚麻肽。 单个环亚麻肽可用于调节与细胞凋亡相关的生理紊乱。 改性亚麻籽油可以通过将没有环亚麻肽的亚麻籽油混合制备，至少一种环亚麻肽用本文公开的方法分离和回收。

公开(公告)号：WO2006076788A1

公开(公告)日：2006-07-27

申请号：PCT/CA2006/000004

申请日：2006-01-04

Applicant: UNIVERSITY OF SASKATCHEWAN ,  BELEV, Gueorgui ,  KASAP, Safa, O.

Inventor： BELEV, Gueorgui ,  KASAP, Safa, O.

IPC: G01T1/28 ,  G01T1/24

CPC classification number: H01L31/18 ,  H01L31/0272 ,  H01L31/085

Abstract: The present invention provides a method for dark current reduction in metal /a-Se/ metal devices, highly suitable for application in high resolution x- ray image detectors for digital mammography is proposed. a-Se is amorphous selenium, stabilized by alloying it with a small amount of As. It is an x-ray photoconductor that is used in an x-ray detector. The method/technology is based mainly on the optimization of the a-Se vacuum deposition process and conditions and is not very sensitive to the composition of the used Se alloy. The detector may be a single layer a-Se or a two-layer a-Se structure, fabricated by the invented processes described herein.

Abstract translation: 本发明提供了一种非常适合用于数字乳腺X线摄影的高分辨率X射线图像检测器的金属/ a-Se /金属器件的暗电流降低方法。 a-Se是无定形硒，通过与少量的As合金化而稳定。 它是用于x射线检测器的x射线感光体。 该方法/技术主要基于a-Se真空沉积工艺和条件的优化，并且对所用Se合金的组成不是很敏感。 检测器可以是通过本文所述的本发明方法制造的单层a-Se或两层a-Se结构。

公开(公告)号：WO2006002520A1

公开(公告)日：2006-01-12

申请号：PCT/CA2005/000991

申请日：2005-06-27

Applicant: UNIVERSITY OF SASKATCHEWAN ,  SHOKROLLAH, Elhai ,  GERDTS, Volker ,  BABIUK, Lorne

Inventor： SHOKROLLAH, Elhai ,  GERDTS, Volker ,  BABIUK, Lorne

IPC: A61K39/39

CPC classification number: A61K38/1709 ,  C07K14/4723

Abstract: Methods for the treatment and prevention of microbial infection, such as infections caused by bacteria, viruses, fungi and parasites are disclosed, as are adjuvants for use with vaccines against such microbes. The methods use porcine β-­defensins, such as porcine β-defensin-1 and are particularly useful for treating or preventing infections caused by gram-negative bacteria, such as pertussis.

Abstract translation: 公开了用于治疗和预防微生物感染（例如由细菌，病毒，真菌和寄生虫引起的感染）的方法，以及用于针对这些微生物的疫苗的佐剂。 该方法使用猪β-防御素，防御素如猪β-防御素-1，并且特别适用于治疗或预防由革兰氏阴性细菌如百日咳引起的感染。

公开(公告)号：WO2005088291A1

公开(公告)日：2005-09-22

申请号：PCT/CA2005/000390

申请日：2005-03-15

Applicant: UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES INC. ,  BARANSKI, Andrzej ,  SUTHERLAND, Todd ,  LONG, Yi-Tao ,  LEE, Jeremy

Inventor： BARANSKI, Andrzej ,  SUTHERLAND, Todd ,  LONG, Yi-Tao ,  LEE, Jeremy

IPC: G01N27/42

CPC classification number: G01N27/3277

Abstract: In various aspects, the invention provides an electrochemical analysis system comprising a fluid-dispensing counter electrode positionable to dispense an electrolyte onto a coated working electrode, wherein electrical energy applied to the system induces a detectable signal that is indicative of a property of the coating on the working electrode.

Abstract translation: 在各个方面，本发明提供一种电化学分析系统，其包括流体分配对电极，其可定位成将电解质分配到涂覆的工作电极上，其中施加到系统的电能引起可检测的信号，其指示涂层的性质 工作电极。

公开(公告)号：WO2005039642A1

公开(公告)日：2005-05-06

申请号：PCT/CA2004/001870

申请日：2004-10-25

Applicant: UNIVERSITY OF SASKATCHEWAN ,  FOLDVARI, Marianna ,  VERRALL, Ronald, E. ,  BADEA, Ildiko

Inventor： FOLDVARI, Marianna ,  VERRALL, Ronald, E. ,  BADEA, Ildiko

IPC: A61K48/00

CPC classification number: A61K9/1272 ,  A61K9/0014 ,  A61K9/1075 ,  A61K31/7088 ,  A61K38/217 ,  A61K48/0033 ,  A61K48/0075 ,  C12N15/88

Abstract: The invention provides a delivery system for a biologically active agent comprising a gemini surfactant in admixture with the biologically active agent in a topical formulation for treatment of skin disorders or metabolic diseases. The invention also provides pharmaceutical compositions in topical formulations comprising the delivery system as set out above, in admixture with pharmaceutically acceptable carriers, diluents, excipients, or supplements suitable for application to the skin or mucosal membrane. Methods of preparation and use are also described.

Abstract translation: 本发明提供了用于生物活性剂的递送系统，其包含与局部制剂中的生物活性剂混合的双子表面活性剂，用于治疗皮肤病或代谢性疾病。 本发明还提供了局部制剂中的药物组合物，其包含如上所述的递送系统，与可药用载体，稀释剂，赋形剂或适用于皮肤或粘膜的补充物混合。 还描述了制备和使用的方法。