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    SHADOW SPHERE LITHOGRAPHY
    191.
    发明申请
    SHADOW SPHERE LITHOGRAPHY 审中-公开
    阴影球面图

    公开(公告)号：WO2015191141A3

    公开(公告)日：2016-02-25

    申请号：PCT/US2015022242

    申请日：2015-03-24

    Applicant: HARVARD COLLEGE

    Inventor： NEMIROSKI ALEX ,  GONIDEC MATHIEU ,  WHITESIDES GEORGE M ,  FOX JEROME M

    IPC: B82Y40/00

    CPC classification number: G05B19/4097 ,  B33Y10/00 ,  B33Y50/02 ,  G03F7/0002

    Abstract: Systems and methods of determining operation parameters for the shadow cast fabrication of micro or nanostructures, the fabrication process using deposition from at least one source over an array of particles, wherein the deposition produces overlapping shadows masking the substrate. A computing device receives a first set of parameter inputs defining particle properties and deposition properties in a shadow cast fabrication, generates data corresponding to a first image for display based on the first set of parameters, receives at least one incremental parameter input that modifies or adds to the first set of parameter inputs, dynamically generates data corresponding to at least one second image for display based on the at least one incremental parameter input, receives an indication that the at least one second image corresponds to a shape ready for fabrication, and generates an output set of fabrication parameters corresponding to the shape ready for fabrication.

    Abstract translation: 确定用于微型或纳米结构的阴影铸造制造的操作参数的系统和方法，所述制造工艺使用来自至少一个源的在颗粒阵列上的沉积，其中所述沉积产生掩蔽所述衬底的重叠阴影。 计算设备接收在阴影投影制作中定义粒子属性和沉积属性的第一组参数输入，基于第一组参数生成对应于第一图像以显示的数据，接收修改或添加的至少一个增量参数输入 基于所述至少一个增量参数输入，动态产生对应于至少一个第二图像以显示的数据，接收所述至少一个第二图像对应于准备制造的形状的指示，并产生 对应于准备制造的形状的制造参数的输出组。

    PNEUMATIC INSECT ROBOTS
    192.
    发明申请
    PNEUMATIC INSECT ROBOTS 审中-公开
    气动车手机

    公开(公告)号：WO2015200844A2

    公开(公告)日：2015-12-30

    申请号：PCT/US2015038093

    申请日：2015-06-26

    Applicant: HARVARD COLLEGE

    Inventor： SHEVCHENKO YANINA ,  WHITESIDES GEORGE M ,  STOKES ADAM ,  COMPTON GABRIELLE

    IPC: F15B15/10 ,  B62D57/032

    CPC classification number: F15B15/103 ,  B62D57/032 ,  F15B2215/305

    Abstract: A modular pneumatic robotic actuator, including a first elongated hollow structure and a second elongated hollow structure connected to each other at a moveable joint; an inflatable bladder comprised of an elastomeric material disposed at the said joint and immobilized between the first and second hollow structures, wherein the said inflatable bladder inflates preferentially away from the joint; and a restraining membrane comprised of an elastomeric material disposed over the bladder and connecting the first and second hollow structures, wherein the said restraining membrane is relaxed when the bladder is deflated.

    Abstract translation: 一种模块化气动机械手致动器，包括在可移动接头处彼此连接的第一细长中空结构和第二细长中空结构; 可膨胀囊，由弹性材料构成，设置在所述接头处并固定在第一和第二中空结构之间，其中所述可充气囊优先从接头膨胀; 以及由弹性体材料组成的限制膜，所述弹性体材料设置在所述囊上并连接所述第一和第二中空结构，其中当所述囊被放气时，所述约束膜松弛。

    APPARATUS, SYSTEMS, AND METHODS FOR MODULAR SOFT ROBOTS
    193.
    发明申请
    APPARATUS, SYSTEMS, AND METHODS FOR MODULAR SOFT ROBOTS 审中-公开
    用于模块化软机器人的装置，系统和方法

    公开(公告)号：WO2014015146A3

    公开(公告)日：2014-04-10

    申请号：PCT/US2013051092

    申请日：2013-07-18

    Applicant: HARVARD COLLEGE

    Inventor： MORIN STEPHEN A ,  KWOK SEN W ,  SHEPHERD ROBERT F ,  WHITESIDES GEORGE M

    IPC: B25J18/06

    CPC classification number: B25J18/06 ,  Y10T74/20305

    Abstract: Apparatus, systems, and methods for providing modular soft robots are disclosed. In particular, the disclosed modular soft robot can include a flexible actuator having a plurality of molded flexible units. Each molded flexible unit can include a mechanical connector configured to provide a physical coupling to another molded flexible unit, and the plurality of molded flexible units are arranged to form an embedded fluidic channel. The modular soft robot can also include an inlet coupled to the embedded fluidic channel, where the inlet is configured to receive pressurized or depressurized fluid to inflate or deflate a portion of the flexible actuator, thereby causing an actuation of the flexible actuator.

    Abstract translation: 公开了用于提供模块化软机器人的设备，系统和方法。 特别地，所公开的模块化软机器人可以包括具有多个模制柔性单元的柔性致动器。 每个模制柔性单元可以包括机械连接器，该机械连接器被配置为提供到另一个模制柔性单元的物理连接，并且多个模制柔性单元被布置成形成嵌入流体通道。 模块化软机器人还可以包括耦合到嵌入流体通道的入口，其中入口构造成接收加压或减压流体以使柔性致动器的一部分膨胀或收缩，从而引起柔性致动器的致动。

    SYSTEMS AND METHODS FOR AMPLIFICATION AND PHAGE DISPLAY
    194.
    发明申请
    SYSTEMS AND METHODS FOR AMPLIFICATION AND PHAGE DISPLAY 审中-公开
    放大和污染显示的系统和方法

    公开(公告)号：WO2012047324A3

    公开(公告)日：2012-09-07

    申请号：PCT/US2011039932

    申请日：2011-06-10

    Applicant: HARVARD COLLEGE ,  DERDA RATMIR ,  TANG SINDY K Y ,  WHITESIDES GEORGE M

    Inventor： DERDA RATMIR ,  TANG SINDY K Y ,  WHITESIDES GEORGE M

    IPC: C12N15/10 ,  C40B40/02 ,  C40B50/06

    CPC classification number: C12N15/1037 ,  C40B40/02 ,  C40B50/06

    Abstract: The present invention generally relates to amplification of biological entities, for example, for phage display. In one aspect, members of a library of biological entities are encapsulated in separate compartments (e.g., in separate microfluidic droplets) and amplified. As a specific example, by putting members of a phage display library into microfluidic droplets such that no droplet contains more than one member of the library, the library can be amplified without any substantial changes in growth rates or population distributions, or other artifacts created due to differences in growth rates or amplification between different members of the library. In some cases, the volume of the compartments can be used to control the copy number of a biological entity during amplification. In certain cases, biological entities with different amplification rates can be amplified independently of each other. In some embodiments, the ratio of a rapidly amplifying biological entity to a slowly amplifying biological entity can be controlled. This can be advantageous, for example, in preserving diversity within a library by preventing rapidly amplifying biological entities from outcompeting slowly amplifying biological entities. For example, certain methods and systems of the invention can be useful in situations where preferential amplification of library members can present a problem.

    Abstract translation: 本发明通常涉及生物实体的扩增，例如用于噬菌体展示。 在一个方面，生物实体文库的成员被包封在分离的隔室中（例如，在单独的微流体液滴中）并被扩增。 作为具体实例，通过将噬菌体展示文库的成员置于微流体液滴中，使得没有液滴含有多于一个文库的成员，可以扩增文库，而不增加生长速率或群体分布或由其产生的其他工件 图书馆不同成员之间的增长速度差异或差异。 在一些情况下，隔室的体积可以用于在放大期间控制生物实体的拷贝数。 在某些情况下，具有不同扩增率的生物实体可以彼此独立地扩增。 在一些实施方案中，可以控制快速扩增的生物实体与缓慢扩增的生物实体的比例。 这可能是有利的，例如，通过防止快速扩增生物实体从超竞争的缓慢扩大的生物实体来保存文库内的多样性。 例如，本发明的某些方法和系统可用于库成员的优先扩增可能存在问题的情况。

    PAPER-BASED CELLULAR ARRAYS
    195.
    发明申请
    PAPER-BASED CELLULAR ARRAYS 审中-公开
    基于纸张的细胞阵列

    公开(公告)号：WO2009120963A3

    公开(公告)日：2010-03-04

    申请号：PCT/US2009038566

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE ,  DERDA RATMIR ,  LAROMAINE SAGUE ANNA ,  WHITESIDES GEORGE M

    Inventor： DERDA RATMIR ,  LAROMAINE SAGUE ANNA ,  WHITESIDES GEORGE M

    IPC: G01N35/00 ,  C12Q1/02 ,  G01N33/48

    CPC classification number: G01N33/548 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00619 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00743 ,  B01L3/5085 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/126 ,  B01L2300/161 ,  G01N33/502

    Abstract: Three-dimensional cellular arrays, methods of making three-dimensional cellular arrays, and methods of identifying agents using the arrays are disclosed. A three-dimensional cellular array includes a porous, hydrophilic substrate comprising a plurality of porous regions, each porous region bounded at least in part by a liquid impervious boundary; and a hydrogel comprising cells, wherein the hydrogel is embedded within the porous regions. A method of making a three-dimensional cellular array comprises providing a porous, hydrophilic substrate, wherein the substrate comprises a plurality of porous regions, each porous region bounded at least in part by a liquid impervious boundary; and contacting the porous, hydrophilic substrate with a suspension of cells and a temperature-sensitive hydrogel or an ionotropic hydrogel precursor, wherein the suspension saturates one or more porous regions of the substrate. A method of identifying an agent comprises providing an array described that modifies cellular function; contacting the array with one or more test agents; and detecting one or more cellular functions in the presence of the one or more test agents; wherein a change in cellular function in the presence of the one or more test agents indicates the one or more test agents modify cellular function.

    Abstract translation: 公开了三维细胞阵列，制备三维细胞阵列的方法以及使用阵列识别药剂的方法。 三维细胞阵列包括多孔亲水基底，其包括多个多孔区域，每个多孔区域至少部分地由不透液体的边界限定; 和包含细胞的水凝胶，其中所述水凝胶嵌入多孔区域内。 一种制备三维细胞阵列的方法包括提供多孔的亲水基底，其中所述基底包括多个多孔区域，每个多孔区域至少部分地由不透液体的边界界定; 以及使所述多孔亲水基底与细胞悬浮液和温度敏感的水凝胶或离子型水凝胶前体接触，其中所述悬浮液饱和所述基底的一个或多个多孔区域。 识别试剂的方法包括提供修饰细胞功能的描述的阵列; 将阵列与一种或多种测试剂接触; 以及在所述一种或多种测试剂的存在下检测一种或多种细胞功能; 其中在所述一种或多种测试剂存在下细胞功能的改变指示所述一种或多种测试试剂修饰细胞功能。

    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM
    196.
    发明申请
    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM 审中-公开
    棉线作为低成本多测量诊断平台

    公开(公告)号：WO2009121043A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2009038702

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE ,  RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    Inventor： RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    IPC: G01N35/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N33/50

    CPC classification number: B01L3/5023 ,  B01L3/5088 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0825 ,  B01L2300/0845 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0406 ,  G01N33/54386

    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread. A method of detecting the presence or absence of an analyte in a fluid sample includes applying the sample to an inlet zone of a diagnostic system that includes a hydrophilic loading thread with an inlet zone at a proximal end; an intermediate zone; and a testing zone at a distal end; wherein the testing zone does not directly contact the inlet zone.

    Abstract translation: 描述了作为廉价，低容量，便携式诊断系统的平台的亲水丝线及其制造方法。 诊断系统包括在近端具有入口区域的亲水加载螺纹; 远端的测试区; 以及位于入口区域和测试区域之间的中间区域，其中测试区域不直接接触入口区域。 在另一方面，诊断系统包括（i）亲水加载线，其包括在近端处的入口区域和在远端处的中间区域; 和（ii）接触加载螺纹的中间区域的一个或多个附加亲水丝线。 检测流体样品中分析物的存在或不存在的方法包括将样品施加到诊断系统的入口区域，诊断系统的入口区域包括具有近端的入口区域的亲水加载螺纹; 中间区 和远端的测试区; 其中所述测试区域不直接接触所述入口区域。

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