公开(公告)号：WO1989005605A1

公开(公告)日：1989-06-29

申请号：PCT/US1988004533

申请日：1988-12-19

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  WILKINS, Ebtisam, S.

IPC: A61B05/00

CPC classification number: G01N27/3335

Abstract: An improved membrane electrode (11) for measuring the concentration of a non-ionic species in an essentially aqueous medium comprising: an electrically conductive substrate (17); a first coating (13) surrounding said substrate (17) composed of a mixture of polymeric material, an anion exchange material, and a water-insoluble alkaline earth metal salt of said non-ionic species, and a hydrogel coating (15) of material surrounding said first coating (13) having a positive charge of sufficient potential to prevent leaching of the substantial amounts of the alkaline earth metal component of said salt.

公开(公告)号：WO1989000398A1

公开(公告)日：1989-01-26

申请号：PCT/US1987001737

申请日：1987-07-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  COTMAN, Carl, W. ,  LYNCH, Gary

IPC: A61B05/00

CPC classification number: A61B5/00 ,  A61B5/4011

Abstract: Persons suspected of being afflicted with Alzheimer's disease or related diseases can be diagnosed by application of a match-to-sample olfactory test using a panel of unfamiliar odors. Persons afflicted with these diseases are unable to match unfamiliar odors, whereas normal individuals are invariably capable of doing so with a high degree of accuracy.

Abstract translation: 怀疑患有阿尔茨海默病或相关疾病的人可以通过使用不熟悉的气味的小组进行匹配样本嗅觉测试来诊断。 患有这些疾病的人不能匹配不熟悉的气味，而正常人总是能够高精度地进行。

公开(公告)号：WO1988006424A1

公开(公告)日：1988-09-07

申请号：PCT/JP1988000235

申请日：1988-03-03

Applicant: TERUMO KABUSHIKI KAISHA ,  SEKII, Shigekazu ,  IKEDA, Makoto ,  TSUCHIDA, Kouji

Inventor： TERUMO KABUSHIKI KAISHA

IPC: A61B05/00

CPC classification number: G01R1/073 ,  A61B5/00 ,  A61B5/028 ,  G16H40/63

Abstract: An apparatus for measuring data of a living body by contacting a probe to the living body or by inserting it in the living body. The apparatus comprises a living body data detecting circuit for electrically detecting data of a living body and a living body data processing circuit for digitally processing the detected data of the living body. The signals are exchanged between the living body data detecting circuit and the living body data processing circuit under an electrically insulated condition. Preferably, there are provided a first power source circuit which supplies electric power to the living body data detecting circuit only and a second power source circuit, which supplies electric power to the first power source circuit, and the electric power is supplied from the second power source circuit to the first power source circuit under the electrically insulated condition. Preferably, furthermore, the electric bias quantity applied to the detector element in the probe is compared with the bias quantity that is fed back through the detector element, in order to detect the presence of any leakage current in the living body. More preferably, an electric quantity of an element for correcting electric charateristics of the detector element in the probe is read prior to measuring the data of a living body, in order to make sure the presence of probe connection and the type thereof.

公开(公告)号：WO1988002234A1

公开(公告)日：1988-04-07

申请号：PCT/JP1987000705

申请日：1987-09-25

Applicant: HITACHI CONSTRUCTION MACHINERY CO., LTD. ,  KUCHIWAKI, Hiroji ,  KAGEYAMA, Naoki ,  ITO, Junki ,  SAKUMA, Nobumitsu ,  OGURA, Yukio

Inventor： HITACHI CONSTRUCTION MACHINERY CO., LTD.

IPC: A61B05/00

CPC classification number: A61B5/031 ,  A61B5/7257 ,  A61B8/0808 ,  A61B8/0858

Abstract: Apparatus for measuring intracranial pressure of a living body to be inspected utilizing ultrasonic waves. With this measuring apparatus, a probe which produces trigger signals is brought into contact with the cranium of the living body to be inspected so that ultrasonic pulses are introduced into the cranium for the frequency analyzation of the data on interfering waves being multi-reflected at the boundaries of tissues in the cranium to calculate and produce a time difference from among element waves of the interfered reflected waves. The apparatus is capable of measuring the thickness of the pachymeninx and a change thereof, as well as the intracranial pressure and a change thereof by utilizing a correlation between the intracranial pressure and the thickness of the pachymeninx. According to the conventional methods of measuring the intracranial pressure in most cases, the cranium was penetrated through. With the conventional method which admits no penetration through the cranium, on the other hand, the precision and cost were far from the practicable levels. The present invention has made it possible to easily measure the intracranium pressure from the outside of the cranium without penetrating it through and without adversely affecting the brain, maintaining safety and high reliability. Further, the measurement taken at regular intervals makes it possible to know the intracranial pressure and a pattern of change thereof, enabling the doctors to obtain proper data on diagnosis for the morbidity and to obtain preventive data on a change in a morbid state.

公开(公告)号：WO1988001148A1

公开(公告)日：1988-02-25

申请号：PCT/US1987002018

申请日：1987-08-17

Applicant: PHYSIO-CONTROL CORPORATION

Inventor： PHYSIO-CONTROL CORPORATION ,  PROSSER, Stephen, J. ,  SMITH, Robert, E.

IPC: A61B05/00

CPC classification number: A61B5/14551

Abstract: The disclosed invention is for use in extracting more accurate information from signals employed in pulse oximetry. Basically, pulse oximetry involves the illumination of arterial blood flowing in tissue with light at two wavelengths. Upon emerging from the tissue the light is received by a detector (38) that produces signals that are proportional to the intensity of the light received at each of the wavelengths. Each signal includes a slowly varying baseline component representing the attenuation beta(t) of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation alpha(t) produced by the changing blood volume and oxygen saturation within the finger. The signals produced by the detector (38) are converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The microcomputer (16) extracts the following information from the signal corresponding to each wavelength. VH is determined to be the signal magnitude at a second pulse diastole. VL is, similarly, the signal magnitude at systole of the same pulse. A term DELTAV is identified equal in value to the difference in signal magnitudes at the adjacent systoles. Finally, values are determined for DELTAts and DELTAtp, being the interval between an adjacent systole and diastole and the pulse period, respectively. The microcomputer (16) then determines a value for ROS in accordance with the relationship (I). Empirically derived oxygen saturation curves are used to develop an indication of the oxygen saturation from the value of ROS computed.

公开(公告)号：WO1988001147A1

公开(公告)日：1988-02-25

申请号：PCT/US1987002016

申请日：1987-08-17

Applicant: PHYSIO-CONTROL CORPORATION

Inventor： PHYSIO-CONTROL CORPORATION ,  CHEUNG, Peter, Wing-Poon ,  GAUGLITZ, Karl, F. ,  MASON, Lee, R. ,  PROSSER, Stephen ,  SMITH, Robert, E. ,  WAGNER, Darrell, O. ,  HUNSAKER, Scott, W.

IPC: A61B05/00

CPC classification number: A61B5/14551

Abstract: A feedback control system for use in processing signals employed in pulse transmittance oximetry. The signals are produced in response to light transmitted through, for example, a finger at two different wavelengths. Each signal includes a slowly varying baseline component representing the relatively fixed attenuation of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation produced by the changing blood volume and oxygen saturation within the finger. The signals are processed by the feedback control system before being converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The feedback control system includes a controllable offset subtractor (66), a programmable gain amplifier (168), controllable drivers (44) for the light sources (40, 42), and the microcomputer (16). The microcomputer (16) receives signals from the offset subtractor (66), gain amplifier (68), drivers (44) and A/D converter (72) to produce signals that control the function of the subtractor (66) and drivers (44) in the following manner. Normally, the drivers (44) are maintained within a predetermined current range. In the event the microcomputer (16) senses an output from the converter (72) that is not within a predetermined range, the drive signal is adjusted to produce an acceptable signal. The magnitude of the offset removed by the subtractor (66), as controlled by the microcomputer (16), is maintained at a constant level when the converter (72) output is within a first predetermined range and is a predetermined function of the converter (72) output when that output falls within a second predetermined range.

公开(公告)号：WO1985002333A1

公开(公告)日：1985-06-06

申请号：PCT/US1984001975

申请日：1984-12-03

Applicant: BIOKINETICS, INC.

Inventor： BIOKINETICS, INC. ,  STEUER, Robert, R. ,  HARRIS, David, H.

IPC: A61B05/00

CPC classification number: A61B5/1106 ,  A61B5/03 ,  A61B5/4041 ,  A61B5/4519 ,  A61B5/6828 ,  A61B2560/0425 ,  A61B2562/24 ,  A61N1/36017

Abstract: A portable physiological pressure monitoring device (10) in which the compartment pressure is to be continuously measured. The device (10) includes an alarm (61) for indicating when a predetermined maximum pressure limit is exceeded or when a predetermined minimum pressure is not maintained for a certain period of time. The pressure device (10) also includes a hydrophobic filter (36) which separates a catheter (40) and the sensing compartments (71) of the pressure device (10) for providing sterile operation. A warning also sounds when a battery (51) falls below a given voltage level. Finally, the pressure monitoring device (10) also includes apparatus (18) for measuring nerve conduction velocity and action potential to facilitate better diagnosis and monitoring of compartment syndrome.

公开(公告)号：WO1985000508A1

公开(公告)日：1985-02-14

申请号：PCT/US1984001098

申请日：1984-07-12

Applicant: AMERICAN THERMOMETER CO., INC.

Inventor： AMERICAN THERMOMETER CO., INC. ,  BROWN, George, T., Jr.

IPC: A61B05/00

CPC classification number: A61B5/015

Abstract: A portable unit includes a hand supported housing defining a chamber (20) and having a larger end portion closed by a removable thermoresponsive flexible screen (16) carrying a layer of liquid crystals. The smaller end portion of the housing supports a camera (17) having a lens (21) projecting into the chamber which receives pressurized air through a passage or duct (37). The housing has transparent wall portions (14) for viewing visible patterns on the screen before recording with the camera, and the housing encloses a light source (24) for illuminating the screen.

Abstract translation: 便携式单元包括限定腔室（20）并且具有较大端部部分的手持支撑壳体，所述较大端部部分由携带液晶层的可拆卸热电偶柔性屏幕（16）封闭。 壳体的较小端部支撑具有突出到腔室中的透镜（21）的相机（17），该透镜通过通道（37）接收加压空气。 壳体具有透明壁部分（14），用于在用相机记录之前观察屏幕上的可见图案，并且壳体包围用于照亮屏幕的光源（24）。

公开(公告)号：WO1982003976A1

公开(公告)日：1982-11-25

申请号：PCT/US1982000625

申请日：1982-05-11

Applicant: CLARK KENNETH R ,  BAHR DENNIS E ,  KAHN ALAN R

Inventor： CLARK KENNETH R ,  BAHR DENNIS E

IPC: A61B05/00

CPC classification number: G01L11/006 ,  A61B5/031

Abstract: An apparatus (10) which measures and monitors the pressure within a human body includes a pressure sensor (11) having a housing (30) closed by a pressure sensitive diaphragm (34) to define a plenum (35), an exhaust tube (36) mounted within the plenum (35) which terminates adjacent the inner surface of the diaphragm (34), and tubes (13, 15) which transmit a substantially constant flow of gas into the plenum and which withdraw gas from the exhaust tube (36) to a location remote from the body. Changes in pressure within the body cause the diaphragm (34) to alternately close and open the end of the exhaust tube (36), thereby resulting in an increase or decrease in the pressure within the plenum until an equilibrium pressure is reached. A source (12) of gas pressure is provided, as well as a means for providing a substantially uniform flow rate (R) and means for measuring the pressure (14) within the tube (13) that transmits the gas flow to the sensor (11). The flow rates to and from the sensor (11) are compared, and the flow of gas to the sensor (11) are compared, and the flow of gas to the sensor (11) is cut off if the flow rates are unequal, a condition indicative of a leak in the sensor (11) or in the tubing (13, 15, 17) that transmits the gas to and from the sensor.

Abstract translation: 一种测量和监测人体内的压力的装置（10）包括压力传感器（11），该压力传感器（11）具有由压力敏感隔膜（34）封闭以限定集气室（35）的壳体（30），排气管 ）安装在邻近隔膜（34）的内表面终止的气室（35）内，以及管（13,15），其将基本上恒定的气体流传送到通风室中，并且从排气管（36）抽出气体， 到远离身体的位置。 体内的压力变化使得隔膜（34）交替地关闭和打开排气管（36）的端部，从而导致增压室内的压力增加或减小，直到达到平衡压力。 提供气体压力源（12），以及用于提供基本上均匀流量的装置（R）和用于测量将气体流传递到传感器的管（13）内的压力（14）的装置（ 11）。 比较传感器（11）和从传感器（11）流出的流量，并且比较传感器（11）的气体流量，如果流量不相等，则切断传感器（11）的气体流量， 指示传感器（11）或将气体传递到传感器的管道（13,15,17）中的泄漏的状态。

公开(公告)号：WO1980002794A1

公开(公告)日：1980-12-24

申请号：PCT/US1980000769

申请日：1980-06-20

Applicant: NOVAMETRIX MED SYSTEMS INC

Inventor： NOVAMETRIX MED SYSTEMS INC ,  DALI C ,  RICH D

IPC: A61B05/00

CPC classification number: A61B5/1491 ,  G01N27/404

Abstract: A fixation ring (19) for a transcutaneous gas sensor probe (1) has structure for removably mounting the ring on the probe with a bore in the ring communicating with the electrodes (5, 7) of the probe. The fixation ring includes a membrane (29) and structure for tensioning the membrane in cooperation with the probe when the fixation ring is attached to the probe at which time the membrane permits only gases to which it is permeable to pass through the bore in the fixation ring and into an ion solution in contact with the electrodes of the probe. A cap member (38) removably mountable on the fixation ring is provided with an element (41) for depressing the membrane to prevent excessive ion solution and any entrapped air from accumulating adjacent to the electrodes.