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    201.
    发明专利
    未知

    公开(公告)号：DE59305551D1

    公开(公告)日：1997-04-03

    申请号：DE59305551

    申请日：1993-11-27

    Applicant: BASF AG

    Inventor： SCHLECKER RAINER ,  TREIBER HANS-JOERG ,  BEHL BERTHOLD ,  HOFMANN HANS

    IPC: A61K31/505 ,  A61P25/02 ,  A61P25/20 ,  C07D487/04

    Abstract: PCT No. PCT/EP93/03331 Sec. 371 Date Jun. 1, 1995 Sec. 102(e) Date Jun. 1, 1995 PCT Filed Nov. 27, 1993 PCT Pub. No. WO94/13672 PCT Pub. Date Jun. 23, 1994Novel triazoloquinazolines of the formula I gs stated in the description, and their preparation are described. The compounds are suitable for controlling diseases.

    Novel quinoxalines and drugs prepared therefrom
    207.
    发明专利
    Novel quinoxalines and drugs prepared therefrom 未知

    公开(公告)号：AU1311595A

    公开(公告)日：1996-07-10

    申请号：AU1311595

    申请日：1994-12-21

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED ,  BEHL BERTHOLD ,  HOFMANN HANS PETER

    IPC: A61K31/495 ,  C07D401/14 ,  C07D403/04

    Abstract: PCT No. PCT/EP94/03839 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 21, 1994 PCT Pub. No. WO96/19476 PCT Pub. Date Jun. 27, 1996Quinoxaline-2,3-(1H,4H)-diones of the formula I I and their tautomeric and enantiomeric forms and their physiologically tolerated salts, the variables R, R1 and R2 have the meanings specified in claim 1, and are useful for therapeutic treatment of neurodegenerative disorders, neurotoxic disturbances or as antiepileptics, antidepressants and anxiolytics; and drugs composed thereof.

    NEW HETEROCYCLIC SUBSTITUTED IMIDAZOLOQUINOXALINONES, THEIR PREPARATION AND THEIR USE
    210.
    发明专利
    NEW HETEROCYCLIC SUBSTITUTED IMIDAZOLOQUINOXALINONES, THEIR PREPARATION AND THEIR USE 未知

    公开(公告)号：CA2200358A1

    公开(公告)日：1996-04-11

    申请号：CA2200358

    申请日：1995-09-19

    Applicant: BASF AG

    Inventor： TREIBER HANS-JOERG ,  LUBISCH WILFRIED ,  BEHL BERTHOLD ,  HOFMANN HANS PETER

    IPC: A61K31/495 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/24 ,  A61P25/26 ,  C07D487/04

    Abstract: Imidazoloquinoxalinones have the formula (I), in which R1 stands for hydrogen, branched or linear C1-5-alkyl or a phenyl, pyridyl or thienyl group possibly substituted by one to two chlorine atoms, a trifluoromethyl, a nitrodioxy or a methylene dioxy group; R2 stands for hydrogen, C1-5-alkyl or C3-8-dialkylaminoalkyl; R3 stands for a chlorine or bromine atom, a trifluoromethyl, cyano or nitro group; A stands for a five-membered heterocycle with 1-4 nitrogen atoms or 1-2 nitrogen atoms and one oxygen or sulphur atom possible substituted by R4 and R5; the radicals R4 and R5, that may be the same or different, stand for hydrogen, C1-5-alkyl, C1-5-hydroxyethyl, phenyl, phenyl substituted by a chlorine atom, a trifluoromethyl or nitro group, -CHO, -COOH, -COO-C1-5-alkyl, -CH2-NR6R7 (in which R6 = H, C15-alkyl, R7 = H, C1-5-alkyl), -CH2-NH-CO-R8 (in which R8 = C1-5-alkyl, phenyl, a phenyl group or an heteroaryl group possibly substituted by a chlorine atom of a nitro or trifluoromethyl group) or -CH2-NHCONHR8; and B stands for a bond or a C1-5-alkylene chain. Also disclosed are the tautomer and isomer forms of these compounds, as well as their physiologically compatible salts. These new substances have good glutamate antagonistic effects and are useful for controlling neurodegenerative diseases.

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